Correction - Correction: The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia

Q: What was the specific issue in the original article’s Fig. 5?

In Fig. 5i, the data representing Nalm6 cells (bottom left) was inadvertently a duplicate of data presented in Fig. 5j.

Q: Does the correction change the study’s overall conclusions?

No. The correction does not affect the results or conclusions of the article.

Q: What does the corrected Fig. 5 cover experimentally?

Fig. 5 summarizes JAK/STAT pathway-related findings, including GSEA enrichment, western blot and protein level assessments, Co-IP analysis, treatment effects with sc-43 and garcinone D, and functional assays such as CCK8/EdU and transwell migration/invasion plus PI staining.

Sep 29, 2026

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Correction notice for a study in the Journal of Cancer Research and Clinical Oncology describing an error in Fig. 5i, where Nalm6 cell data (bottom left) was mistakenly duplicated from Fig. 5j. The corrected Fig. 5 is provided in the original publication. The authors state the correction does not alter the article’s results or conclusions. The figure summary includes JAK/STAT pathway activation, protein expression analyses, interaction assays, western blot changes under sc-43 and garcinone D, and functional assays (CCK8, EdU, transwell, PI staining).

LanguageEnglish

CategoryHealthcare

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Pages4

Reading Time10 min

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Correction Notice

Error in Fig. 5i and Provided Correction

Figure 5: Correct vs Incorrect Panel Descriptions

Journal of Cancer Research and Clinical Oncology (2026) 152:27 [https://doi.org/10.1007/s00432-025-06392-7](https://doi.org/10.1007/s00432-025-06392-7) CORRECTION Correction: The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia Liwen Zhu1,2 · Xinyu Li1,2 · Diandian Liu1,2 · Wenke Bai1,2 · Huaqing Yang1,2 · Qianyi Cheng1,2 · Luhong Xu1,2 · Jianpei Fang1,2 © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2026 Journal of Cancer Research and Clinical Oncology (2023) 149:6527-6540 [https://doi.org/10.1007/s00432-02](https://doi.org/10.1007/s00432-02)[ ](https://doi.org/10.1007/s00432-02)3-04613-5 In Fig. 5i of this article, the data representing Nalm6 cells (bottom left) was inadvertently a duplicate of data presented in Fig. 5j. Figure 5 has now been corrected in the original publication. For completeness and transparency, both the The original article can be found online at [https://doi.org/10.1007/s00](https://doi.org/10.1007/s00)[ ](https://doi.org/10.1007/s00)432-023-04613-5. 􀀍 Luhong Xu [xulhong@mail.sysu.edu.cn](xulhong@mail.sysu.edu.cn) 􀀍 Jianpei Fang [fangjpei@mail.sysu.edu.cn](fangjpei@mail.sysu.edu.cn) 1 Department of Pediatrics, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou 510120, Guangdong, People’s Republic of China 2 Guangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China correct and incorrect versions are displayed below. The correction does not affect the results or conclusions of the article. 1 3 Correct Fig. 5. Fig. 5 MAD2L1 promotes B-ALL proliferation and metastasis through the JAK/STAT signaling pathway. A GSEA demonstrated significant enrichment of the JAK/STAT pathway correlating with MAD2L1 expression. B Protein levels of JAK1, p-JAK1, JAK2, p-JAK2, JAK3 and p-JAK3 in B-ALL cells with MAD2L1 overexpression or knockdown were analysed via western blot. C Protein levels of TYK2, p-TYK2, STAT3 and p-STAT3 in B-ALL cells with MAD2L1 overexpression or knockdown were analysed via western blot. D Co-IP analysis of MAD2L1 interacting proteins. E Western blot analysis showed that MAD2L1, TYK2, p-TYK2, STAT3 and p-STAT3 expression levels were modified by sc-43 and garcinone D treatment of B-ALL cells. F–H The CCK8 assay and EdU suggested that sc-43 or garcinone D modified the effect of MAD2L1 upregulation or downregulation on the cell proliferation ability of RS4;11 or Nalm6 cells. I, J The transwell assay demonstrated that sc-43 or garcinone D modified the migration and invasion capability due to MAD2L1 overexpression or downregulation in RS4;11 or Nalm6 cells. K, L Representative histograms of PI staining in the vector, ovMAD2L1 and MAD2L1 + sc-43 of RS4;11 and shNC, shMAD2L1 and shMAD2L1 +garcinone D ofNalm6 cells. Data are shown as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 Incorrect Fig. 5. Fig. 5 MAD2L1 promotes B-ALL proliferation and metastasis through the JAK/STAT signaling pathway. A GSEA demonstrated significant enrichment of the JAK/STAT pathway correlating with MAD2L1 expression. B Protein levels of JAK1, p-JAK1, JAK2, p-JAK2, JAK3 and p-JAK3 in B-ALL cells with MAD2L1 overexpression or knockdown were analysed via western blot. C Protein levels ofTYK2, p-TYK2, STAT3 and p-STAT3 in B-ALL cells with MAD2L1 overexpression or knockdown were analysed via western blot. D Co-IP analysis of MAD2L1 interacting proteins. E Western blot analysis showed that MAD2L1, TYK2, p-TYK2, STAT3 and p-STAT3 expression levels were modified by sc-43 and garcinone D treatment of B-ALL cells. F–H The CCK8 assay and EdU suggested that sc-43 or garcinone D modified the effect of MAD2L1 upregulation or downregulation on the cell proliferation ability of RS4;11 or Nalm6 cells. I, J The t

FAQs

What was the specific issue in the original article’s Fig. 5?

In Fig. 5i, the data representing Nalm6 cells (bottom left) was inadvertently a duplicate of data presented in Fig. 5j.

Does the correction change the study’s overall conclusions?

No. The correction does not affect the results or conclusions of the article.

What does the corrected Fig. 5 cover experimentally?

Fig. 5 summarizes JAK/STAT pathway-related findings, including GSEA enrichment, western blot and protein level assessments, Co-IP analysis, treatment effects with sc-43 and garcinone D, and functional assays such as CCK8/EdU and transwell migration/invasion plus PI staining.

Sep 29, 2026

Uploaded by Callum