Comparison of treatment approaches for mediastinitis after coronary artery bypass grafting - Negative pressure wound therapy versus conventional methods

Q: What is the main purpose of this study?

To compare the effectiveness of negative-pressure wound therapy (NPWT) versus conventional methods for treating mediastinitis after coronary artery bypass grafting.

Q: How were patients grouped in the analysis?

Patients were retrospectively divided into a conventional treatment group (n=39) treated from January 2010 to February 2015 and an NPWT group (n=48) treated from March 2015 to January 2023.

Q: What outcomes were measured and how did NPWT perform?

Treatment duration, time to negative cultures, hospital stay, and mortality rate were recorded; NPWT achieved shorter durations, faster negative cultures, shorter hospitalization, and lower hospital mortality than conventional methods.

Sep 29, 2026

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Study compares negative-pressure wound therapy (NPWT) with conventional treatment methods for mediastinitis following coronary artery bypass grafting. A retrospective analysis covered 87 patients developing mediastinitis after sternotomy between January 2010 and January 2023, divided into conventional (n=39) and NPWT (n=48) groups. NPWT shortened treatment duration, time to negative cultures, and hospital stay, and reduced hospital mortality compared with conventional care. Results support NPWT as a more effective option for this serious postoperative complication.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages11

Reading Time28 min

AccessFree to download

Abstract

Methods and Groups

Results and Outcomes

Conclusion and Keywords

Turkish Journal of Thoracic and Cardiovascular Surgery 2025;33(4):412-422 Orıgınal Artıcle / Özgün Makale Comparison of treatment approaches for mediastinitis after coronary artery bypass grafting: Negative pressure wound therapy versus conventional methods Koroner arter baypas greftleme sonrası mediastinit tedavisinde tedavi yaklaşımlarının karşılaştırıl ması: Negatif basınçlı yara tedavisi ile konvansiyonel yöntemler Hasan Toz􀀬, Yusuf Kuserli􀀬, Gülsüm Türkyılmaz􀀬, Ali Aycan Kavala􀀬, Saygın Türkyılmaz􀀬 Department of Cardiovascular Surgery, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Türkiye ABSTRACT Background: This study aims to compare the effectiveness of negative-pressure wound therapy (NPWT) compared to conventional methods for the treatment of mediastinitis following coronary artery bypass grafting. Methods: Between January 2010 and January 2023, a total of 87 patients (47 males, 40 females; mean age: 62.0±10.2 years; range, 35 to 80 years) who developed mediastinitis following sternotomy were retrospectively analyzed. The patients were divided into two groups: those treated with conventional methods (n=39) from January 2010 to February 2015 and those treated with NPWT (n=48) from March 2015 to January 2023. Clinical outcomes, including treatment duration, infection resolution time, hospital stay, and mortality rate, were recorded. Results: The NPWT group had significantly shorter treatment durations (20.1±4.0 days) than the conventional group (58.6±17.1 days, p<0.001) . The time to achieve negative cultures was also significantly reduced in the NPWT group (15.3±3.6 days) compared to the conventional group (36.7±8.1 days, p<0.001) . The length of hospital stay was shorter in the NPWT group (34.3±12.8 days) compared to the conventional group (88.0±21.1 days, p<0.001) . The NPWT group had a lower hospital mortality rate (4.2%) than the conventional group (17.9%, p=0.049) . Conclusion: The NPWT demonstrated superior efficacy in managing postoperative mediastinitis compared to conventional methods, highlighting its potential as a preferred treatment option for this serious complication. Keywords: Coronary artery bypass grafting, mediastinitis, negativepressure wound therapy, postoperative complications, wound healing. Mediastinitis is a potentially severe and lifethreatening infection which may arise following cardiac interventions, particularly isolated coronary artery bypass grafting (CABG) . [1] This condition ÖZ Amaç: Bu çalışmada, koroner arter baypas greftlemesonrası gelişen mediastinit tedavisinde negatif basınçlı yaratedavisinin (NPWT) etkinliği konvansiyonel yöntemler ile karşılaştırıldı . Çalışma planı: Ocak 2010 - Ocak 2023 tarihleri arasındasternotomi sonrası mediastinit gelişen toplam 87 hasta (47 erkek, 40 kadın; ort. yaş: 62.0±10.2 yıl; dağılım, 35-80 yıl) retrospektif olarak incelendi. Hastalar, Ocak 2010 - Şubat 2015 tarihleri arasında konvansiyonel yöntemlerle tedavi edilenler (n=39) ve Mart 2015 - Ocak 2023 arasında NPWT uygulananlar (n=48) olmak üzere iki gruba ayrıldı . Tedavi süresi, enfeksiyon iyileşmesüresi, hastanede yatış süresi ve mortalite oranları dahil olmak üzere klinik sonuçlar kaydedildi. Bulgular: Negatif basınçlı yara tedavi grubunda tedavi süresikonvansiyonel gruba kıyasla (58.6±17.1 gün) anlamlı olarak daha kısa idi (20.1±4.0 gün, p<0.001) . Negatif kültür elde etmesüresi de, konvansiyonel gruba kıyasla (36.7±8.1 gün), NPWT grubunda anlamlı düzeyde kısaldı (15.3±3.6 gün; p<0.001) . Hastanede kalış süresi, konvansiyonel gruba kıyasla (88.0±21.1 gün), NPWT grubunda daha kısa idi (34.3±12.8 gün; p<0.001) . Hastane mortalitesi, konvansiyonel gruba kıyasla (%17.9), NPWT grubunda daha düşük idi (%4.2; p=0.049) . Sonuç: Negatif basınçlı yara tedavisi ameliyat sonrası mediastinit yönetiminde konvansiyonel yöntemlere kıyasla üstün etkinlikgöstermiş olup, bu ciddi komplikasyonun tedavisinde tercihedilebilecek bir yöntem olarak öne çıkmaktadır

FAQs

What is the main purpose of this study?

To compare the effectiveness of negative-pressure wound therapy (NPWT) versus conventional methods for treating mediastinitis after coronary artery bypass grafting.

How were patients grouped in the analysis?

Patients were retrospectively divided into a conventional treatment group (n=39) treated from January 2010 to February 2015 and an NPWT group (n=48) treated from March 2015 to January 2023.

What outcomes were measured and how did NPWT perform?

Treatment duration, time to negative cultures, hospital stay, and mortality rate were recorded; NPWT achieved shorter durations, faster negative cultures, shorter hospitalization, and lower hospital mortality than conventional methods.

Sep 29, 2026

Upload by Finn