Comparison of the efficacy of different treatments after non-curative endoscopic resection of superficial esophageal carcinoma - A meta-analysis

Q: What is the main objective of this study?

To systematically evaluate the efficacy of different treatments after non-curative endoscopic resection of superficial esophageal carcinoma.

Q: How did recurrence rates compare between observation and adjuvant treatment groups?

Recurrence rate was significantly higher in the observation group than in the adjuvant treatment group (OR = 3.25, 95% CI: 1.88–5.62, P < 0.0001).

Q: What conclusion was drawn about lymphovascular invasion and recurrence risk?

Lymphovascular invasion was identified as a risk factor for recurrence, with a statistically significant higher recurrence rate (OR = 4.01, 95% CI: 1.48–10.84, P = 0.006).

Sep 28, 2026

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Systematically evaluating the efficacy of multiple post-non-curative strategies after endoscopic resection of superficial esophageal carcinoma, this meta-analysis compares adjuvant treatment options. Databases including PubMed, Cochrane Library, Embase, CNKI, and Wanfang Data were searched through November 25, 2025, and quantitative synthesis used Review Manager 5.3 with Stata 15 for supplementary analyses. Thirteen studies with 1,304 patients were included, with recurrence outcomes and risk factors assessed to guide selection of follow-up management.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages10

Reading Time25 min

AccessFree to download

Introduction

Background and definitions

Methods

Literature search and analysis

Results

Study inclusion and recurrence outcomes

Conclusion

Clinical implications

TYPE Systematic Review PUBLISHED 18 December 2025 DOI 10.3389/fonc.2025.1709350 OPEN ACCESS EDITED BY Mingzhou Guo, People’s Liberation Army General Hospital, China REVIEWED BY Yan Wang, Sichuan University, China Lorenzo Giorgi, Humanitas Research Hospital, Italy *CORRESPONDENCE Shu-Ni Tian [plj8353@163.com](plj8353@163.com) RECEIVED 20 September 2025 REVISED 27 November 2025 ACCEPTED 27 November 2025 PUBLISHED 18 December 2025 CITATION Wang R, Peng L-J and Tian S-N (2025) Comparison of the efﬁcacy of different treatments after non-curative endoscopic resection of superﬁcial esophageal carcinoma: a meta-analysis. Front. Oncol. 15:1709350 . doi: 10.3389/fonc.2025.1709350 COPYRIGHT © 2025 Wang, Peng and Tian. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Comparison of the efﬁcacy of different treatments after noncurative endoscopic resection of superﬁcial esophageal carcinoma: a meta-analysis Rui Wang 1, Li-Jun Peng 2,3 and Shu-Ni Tian 3* 1School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China, 2 Department of Gastroenterology, Qingdao Hospital of Peking University People’s Hospital, Qingdao, Shandong, China, 3 Department of Gastroenterology, Linyi People’s Hospital, Linyi, Shandong, China Objective: This study aims to systematically evaluate the efﬁcacy of different treatments after non-curative endoscopic resection for superﬁcial esophageal carcinoma. Methods: Databases including PubMed, the Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang Data were searched from inception to November 25, 2025 . The meta-analysis was performed using Review Manager version 5.3, with Stata version 15 employed for supplementary statistical assessments. Results: A total of 13 studies involving 1,304 patients were included. The results of the meta-analysis showed that the recurrence rate after non-curative endoscopic resection of superﬁcial esophageal carcinoma was signiﬁcantly higher in the observation group than in the adjuvant treatment group (OR = 3. 25, 95% CI: 1 .88–5. 62, P < 0 . 0001) . However, there was no signiﬁcant difference in recurrence rate between the chemoradiotherapy group and the surgery group (OR = 0 . 65, 95% CI: 0 .23–1. 84, P = 0 . 42) . Patients with lymphovascular invasion had a higher recurrence rate, which was statistically signiﬁcant (OR = 4 . 01, 95% CI: 1 .48–10. 84, P = 0 . 006) . Conclusion: Lymphovascular invasion is a risk factor for recurrence in patients. The adjuvant treatment group shows signiﬁcantly reduced recurrence rates compared to the observation group, with no signiﬁcant difference in recurrence rates between surgical and chemoradiotherapeutic approaches. Systematic review registration: [https://www. crd.york. ac.uk/prospero/](https://www. crd.york. ac.uk/prospero/) , identiﬁer CRD420251108299 . KEYWORDS esophageal carcinoma, meta-analysis, non-curative endosco pic resection, radiotherapy, surgery Frontiers in Oncology 01 [frontiersin.org](frontiersin.org) 1 Introduction Esophageal cancer is one of the most common malignancies, ranking 11th in global incidence and seventh in mortality worldwide (1), and it is the ﬁfth leading cause of cancer mortality in China (2), according to the Global Cancer Statistics 2022 . Superﬁcial esophageal carcinoma is deﬁned as carcinoma conﬁned to the mucosa (T1a) or submucosa (T1b), irrespective of lymph node or distant metastasis. Based on the depth of invasion, mucosal esophageal cancer may be limited to the epithelium (M1), lamina

FAQs

What is the main objective of this study?

To systematically evaluate the efficacy of different treatments after non-curative endoscopic resection of superficial esophageal carcinoma.

Which databases and statistical tools were used in the meta-analysis?

PubMed, Cochrane Library, Embase, CNKI, and Wanfang Data were searched to November 25, 2025. Review Manager 5.3 was used for the meta-analysis, with Stata version 15 for supplementary statistical assessments.

How did recurrence rates compare between observation and adjuvant treatment groups?

Recurrence rate was significantly higher in the observation group than in the adjuvant treatment group (OR = 3.25, 95% CI: 1.88–5.62, P < 0.0001).

What conclusion was drawn about lymphovascular invasion and recurrence risk?

Lymphovascular invasion was identified as a risk factor for recurrence, with a statistically significant higher recurrence rate (OR = 4.01, 95% CI: 1.48–10.84, P = 0.006).

Sep 28, 2026

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