Comparison of prognosis after transurethral resection of bladder tumor between solitary and multiple bladder cancers

Q: What does the study compare between solitary and multiple bladder cancers?

The study compares postoperative overall survival rates after transurethral resection of bladder tumor and related outcomes between solitary and multiple bladder cancers.

Q: How was the study conducted and how many patients were analyzed?

A retrospective analysis included 133 patients treated between April 2017 and October 2023, and 112 patients with complete baseline and follow-up data were used for the comparison.

Q: What key results distinguish solitary from multiple bladder cancers after surgery?

Multiple bladder cancers had higher pathological grade, larger tumor diameter, higher recurrence, and worse overall survival than solitary bladder cancers after transurethral resection.

Q: Is tumor number a risk factor for survival in this study?

Yes. Univariate and multivariate regression analyses identified the number of bladder tumors as an independent risk factor for overall survival after surgery (P=.004).

Sep 21, 2026

Uploaded by Skyler

This retrospective observational study compares overall survival and postoperative outcomes between solitary and multiple bladder cancers after transurethral resection of bladder tumor. Data were collected from 133 patients treated from April 2017 to October 2023, with 112 having complete baseline and follow-up information. Recurrence occurred in 23.21% (26/112). Overall survival was 92.11% (35/38) in solitary cases versus 74.32% (55/74) in multiple cases (P=.025). Multiple tumors showed higher grade, larger diameter, and poorer prognosis. Tumor number was an independent risk factor for overall survival (P=.004).

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages4

Reading Time10 min

AccessFree to download

Abstract

Introduction

Methods

® Observational Study Comparison of prognosis after transurethral resection of bladder tumor between solitary and multiple bladder cancers Mingxin Diao, MDa , Yue Li, MDb , Zihui Gao, MDa , Chunji Wang, MDa , Yaming Gu, MDa ,* | Abstract
This study investigates the difference in overall survival rates after transurethral resection of bladder tumor between solitary and multiple bladder cancers, aiming to provide guidance for clinical practitioners. A retrospective analysis was conducted on 133 patients with bladder cancer who underwent transurethral resection of bladder tumor from April 2017 to October 2023, of which 112 patients had complete clinical and follow-up data. Clinical and follow-up data were collected, and the overall survival rates after surgery were compared between solitary and multiple bladder cancers. In this study, the recurrence rate after transurethral resection of bladder tumor was 23.21%(26/112), and the overall survival rate was 80.36%(90/112) . The overall survival rate after transurethral resection of bladder tumor was 92. 11%(35/38) in the solitary bladder cancer group and 74.32%(55/74) in the multiple bladder cancer group, with a statistically significant difference between the 2 groups (P = .025) . The proportion of high-grade pathology was 7.89%(3/38) in the solitary bladder cancer group and 25.68%(19/74) in the multiple bladder cancer group after transurethral resection of bladder tumor, with a statistically significant difference between the 2 groups (P = .025) . The mean tumor diameter after transurethral resection of bladder tumor was 2.76 ± 1.66 cm in the solitary bladder cancer group and 4.04 ± 3.17 cm in the multiple bladder cancer group, with a statistically significant difference between the 2 groups (P = .023) . Univariate and multivariate regression analyses revealed that the number of bladder tumors is a risk factor for overall survival after bladder cancer surgery (P = .004) . Multiple bladder cancers have a higher pathological grade, larger tumor diameter, and poorer prognosis after transurethral resection of bladder tumor compared to solitary bladder cancers. The number of bladder tumors isan independent risk factor for overall survival after bladder cancer surgery. | | --- | | Keywords: multiple bladder cancer, prognosis, solitary bladder cancer, transurethral resection of bladder tumor | 1. Introduction Bladder cancer is the 10th most common cancer and the 13th most common cause of cancer deaths, and because of its high rate of recurrence, it imposes a significant financial and health burden on patients.[1,2] Due to the inherently aggressive nature of bladder cancer and its susceptibility to recurrence, patients usually require multimodality and invasive treatments, such as repeated transurethral cystectomy of bladder tumors combined with bladder perfusion chemotherapy, but the 5-year recurrence-free survival rate is still <43% .[3–5] Bladder cancer is classified into non-muscle-invasive bladder cancer and muscle-invasive bladder cancer based on the depth of infiltration into the bladder tissue, with the latter exhibiting a higher tendency for distant metastasis and poorer prognosis.[6–8] MD and YL contributed equally to this work. Informed consent for this retrospective analysis was waived. The authors have no funding and conflicts of interest to disclose. The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request. The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The trial was conducted in accordance with the Declaration of Helsinki (as revised in 2013). This study was approved by the Ethics Committee of Peking University First Hospital-Miyun Hospital (No. 2023-029-001). a Department of Urology, Peking University First Hospital-Miyun Hospita

FAQs

What does the study compare between solitary and multiple bladder cancers?

The study compares postoperative overall survival rates after transurethral resection of bladder tumor and related outcomes between solitary and multiple bladder cancers.

How was the study conducted and how many patients were analyzed?

A retrospective analysis included 133 patients treated between April 2017 and October 2023, and 112 patients with complete baseline and follow-up data were used for the comparison.

What key results distinguish solitary from multiple bladder cancers after surgery?

Multiple bladder cancers had higher pathological grade, larger tumor diameter, higher recurrence, and worse overall survival than solitary bladder cancers after transurethral resection.

Is tumor number a risk factor for survival in this study?

Yes. Univariate and multivariate regression analyses identified the number of bladder tumors as an independent risk factor for overall survival after surgery (P=.004).

Sep 21, 2026

Uploaded by Skyler