Colonoscopy Outcomes by Duration of NPO Status Prior to Colonoscopy with Moderate or Deep Sedation - Research Report

Sep 27, 2026

Evidence-based Synthesis Program report synthesizing outcomes of colonoscopy according to the duration of NPO status before the procedure when moderate or deep sedation is used. The document provides an executive summary, outlines methods including data sources and searches, study selection, abstraction, risk-of-bias assessment, and data synthesis and analysis. It presents results from the literature search, key question findings, and a discussion of key findings, strength of evidence, applicability, and research gaps, concluding with overall conclusions and abbreviations.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages101

Reading Time4 h 15 min

AccessFree to download

Executive Summary

Introduction

Methods

Results

Discussion

Applicability

Research Gaps/Future Research

Conclusions

Abbreviations

| Department of Veterans Affairs
Health Services Research & Development Service | Evidence-based Synthesis Program | | | --- | --- | --- | Colonoscopy Outcomes by Duration of NPO Status Prior to Colonoscopy with Moderate or Deep Sedation January 2015 Prepared for: Department of Veterans Affairs Veterans Health Administration Quality Enhancement Research Initiative Health Services Research & Development Service Washington, DC 20420 Prepared by: Evidence-based Synthesis Program (ESP) Center Minneapolis VA Medical Center Minneapolis, MN Timothy J. Wilt, MD, MPH, Director Investigators: Principal Investigator: Aasma Shaukat, MD, MPH Co-Investigators: Joseph Wels, MDAshish Malhotra, MD Nancy Greer, PhD Timothy J. Wilt, MD, MPH Research Assistants: Roderick MacDonald, MS Maureen Carlyle, MPHIndulis Rutks, BS PREFACE Quality Enhancement Research Initiative’s (QUERI) Evidence-based Synthesis Program (ESP) was established to provide timely and accurate syntheses of targeted healthcare topics of particular importance to Veterans Affairs (VA) clinicians, managers and policymakers as they work to improve the health and healthcare of Veterans. The ESP disseminates these reports throughout the VA, and some evidence syntheses inform the clinical guidelines of large professional organizations. QUERI provides funding for four ESP Centers and each Center has an active university affiliation. The ESP Centers generate evidence syntheses on important clinical practice topics, and these reports help: • develop clinical policies informed by evidence; • guide the implementation of effective services to improve patient outcomes and to support VA clinical practice guidelines and performance measures; and • set the direction for future research to address gaps in clinical knowledge. In 2009, the ESP Coordinating Center was created to expand the capacity of HSR&D Central Office and the four ESP sites by developing and maintaining program processes. In addition, the Center established a Steering Committee comprised of QUERI field-based investigators, VA Patient Care Services, Office of Quality and Performance, and Veterans Integrated Service Networks (VISN) Clinical Management Officers. The Steering Committee provides program oversight, guides strategic planning, coordinates dissemination activities, and develops collaborations with VA leadership to identify new ESP topics of importance to Veterans and the VA healthcare system. Comments on this evidence report are welcome and can be sent to Nicole Floyd, ESP Coordinating Center Program Manager, [at](at Nicole.Floyd@va.gov)[ ](at Nicole.Floyd@va.gov)[Nicole.Floyd@va.gov](at Nicole.Floyd@va.gov). Recommended citation: Example: Shaukat A, Wels J, Malhotra A, Greer N, MacDonald R, Carlyle M, Rutks I, and Wilt T J. Colonoscopy Outcomes by Duration of NPO Status Prior to Colonoscopy with Moderate or Deep Sedation. VA ESP Project \#09-009; 2015. This report is based on research conducted by the Evidence-based Synthesis Program (ESP) Center located at the Minneapolis VA Medical Center, Minneapolis, MN, funded by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Quality Enhancement Research Initiative. The findings and conclusions in this document are those of the author(s) who are responsible for its contents; the findings and conclusions do not necessarily represent the views of the Department of Veterans Affairs or the United States government. Therefore, no statement in this article should be construed as an official position of the Department of Veterans Affairs. No investigators have any affiliations or financial involvement (eg, employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties) that conflict with material presented in the report. TABLE OF CONTENTS EXECUTIVE SUMMARY Introduction....................................

FAQs

What clinical factor does the report focus on before colonoscopy?

The report focuses on the duration of NPO (nothing by mouth) status prior to colonoscopy when moderate or deep sedation is used.

How does the report describe its evidence synthesis approach?

It details methods including data sources and searches, study selection, data abstraction with risk of bias assessment, and data synthesis and analysis.

What kinds of outcomes and evidence conclusions are provided?

The report presents results from the literature search, summarizes outcomes in included studies, discusses key findings and the strength of evidence, and describes applicability, research gaps, and overall conclusions.

Sep 27, 2026

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