Clinicopathological characteristics and prognosis of triple-negative breast cancer invasive ductal carcinoma with ductal carcinoma in situ

Q: What is the main objective of the study?

To compare and analyze clinicopathological characteristics and prognosis between IDC-DCIS and IDC in triple-negative breast cancer, and to identify factors affecting prognosis for clinical decision-making.

Q: How were patients grouped and how were outcomes assessed?

Patients who underwent surgery for TNBC from October 2012 to December 2018 were retrospectively analyzed and divided into IDC-DCIS and IDC groups, with clinicopathological comparisons and statistical testing (P<0.05 significant).

Q: What did the study find about disease-free survival and overall survival?

Disease-free survival was better in the IDC-DCIS group than in the IDC group (5-year DFS 87.9% vs. 82.6%, P=0.045), while overall survival showed no statistical difference (5-year OS 96.2% vs. 96.0%, P=0.573).

Q: Which factors were identified as independent prognostic factors for disease-free survival?

The coexistence of DCIS, lymph node pathologic stage, tumor location, and adjuvant chemotherapy were independent prognostic factors for disease-free survival.

Sep 24, 2026

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A retrospective study compares clinicopathological features and prognosis in triple-negative breast cancer patients with invasive ductal carcinoma coexisting with ductal carcinoma in situ (IDC-DCIS) versus pure invasive ductal carcinoma (IDC). Patients treated surgically between 2012 and 2018 were divided into IDC-DCIS and IDC groups, and key variables were evaluated with statistical significance at P<0.05. The IDC-DCIS group showed better disease-free survival, while overall survival did not differ. Coexistence of DCIS, lymph node pathologic stage, tumor location, and adjuvant chemotherapy emerged as independent DFS prognostic factors.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages11

Reading Time28 min

AccessFree to download

Abstract

Purpose

Methods

Results

Conclusion

Introduction

Breast cancer subtypes and TNBC

DCIS and IDC relationship

Methods

Patient population

Journal of Cancer Research and Clinical Oncology (2023) 149:11181–11191 [https://doi.org/10.1007/s00432-023-04895-9](https://doi.org/10.1007/s00432-023-04895-9) Clinicopathological characteristics and prognosis of triple‑negative breast cancer invasive ductal carcinoma with ductal carcinoma in situ Yang Liu1 · Tong Yu1 Received: 19 April 2023 / Accepted: 20 May 2023 / Published online: 24 June 2023 © The Author(s) 2023 Abstract Purpose The purpose of this study is to compare and analyze the clinicopathological characteristics and prognosis of patients with invasive ductal carcinoma coexisting with ductal carcinoma in situ (IDC-DCIS) and invasive ductal carcinoma (IDC) in triple-negative breast cancer (TNBC), and to explore the factors affecting the prognosis, so as to provide new ideas for clinical diagnosis and treatment of these patients. Methods The patients with TNBC underwent surgery in the Department of Breast Surgery of Harbin Medical University Cancer Hospital from October 2012 to December 2018 were retrospectively analyzed and divided into IDC-DCIS group and IDC group. The clinicopathological characteristics and prognosis of the two groups were compared. P < 0.05 was considered statistically significant. Results A total of 358 patients were enrolled. There were significant differences in age (P = 0.002), family history (P = 0.016), menopausal status (P = 0.003), KI-67%(P < 0.001), lymphovascular invasion (P = 0.010), histologic grade ofIDC (P < 0.001) and multifocal (P < 0.001) between the two groups. The disease-free survival (DFS) ofthe IDC-DCIS group was better than that ofthe IDC group (the 5-year DFS was 87.9% vs. 82.6%, P = 0.045), but the overall survival (OS) of the two groups was not statistically significant (the 5-year OS was 96.2% vs. 96.0%, P = 0.573) . In addition, the coexistence of DCIS (P = 0.030), lymph node pathologic stage (P = 0.001), tumor location (P = 0.011), and adjuvant chemotherapy (P < 0.001) were independent prognostic factors for DFS. Conclusion In TNBC, the IDC-DCIS group had less invasive biological characteristics. The DFS of the IDC-DCIS group was better than that of the IDC group, but there was no statistical difference in OS between the two groups. In addition, the coexistence of DCIS, lymph node stage, tumor location and adjuvant chemotherapy may be independent prognostic factors for DFS. Keywords TNBC · IDC-DCIS · Clinicopathological characteristics · Prognosis Introduction Breast cancer has a high incidence among female cancer patients in the world, and its related mortality has jumped to the second place (Siegel et al. 2021 ; Bray et al. 2018) . According to the expression of ER, PR, Her-2 and KI-67, breast cancer has been classified into four types: luminal A type, luminal B type, Her-2 overexpression type and triple negative type (Lam et al. 2014) . TNBC is a special molecular subtype, meaning that ER, PR and Her-2 are all * Yang Liu [liuyang0060@sina.com](liuyang0060@sina.com) 1 Department of Breast Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin 150040, China expressed negatively, and accounts for 15% of all breast cancers. Its high invasiveness and susceptibility to recurrence and metastasis result in the worst prognosis of all subtypes (Tariq and Rana 2013; Foulkes et al. 2010 ; Stagg and Allard 2013) . DCIS refers to the proliferation of tumor epithelial cells in the ductal lobular system. These abnormal epithelial cells have the morphological characteristics of invasive carcinoma of the breast, but they are different from invasive carcinoma. It is surrounded by myoepithelial cells and basement membrane of the duct and does not invade the stroma or lymphatic vessels or blood vessels (Pang et al. 2016) . However, DCIS itself does not cause metastatic disease or death, it is regarded as a non-specific precursor of invasive breast cancer (Lagios and Silverstein 2015) . IDC is the most common type of breast cancer,

FAQs

What is the main objective of the study?

To compare and analyze clinicopathological characteristics and prognosis between IDC-DCIS and IDC in triple-negative breast cancer, and to identify factors affecting prognosis for clinical decision-making.

How were patients grouped and how were outcomes assessed?

Patients who underwent surgery for TNBC from October 2012 to December 2018 were retrospectively analyzed and divided into IDC-DCIS and IDC groups, with clinicopathological comparisons and statistical testing (P<0.05 significant).

What did the study find about disease-free survival and overall survival?

Disease-free survival was better in the IDC-DCIS group than in the IDC group (5-year DFS 87.9% vs. 82.6%, P=0.045), while overall survival showed no statistical difference (5-year OS 96.2% vs. 96.0%, P=0.573).

Which factors were identified as independent prognostic factors for disease-free survival?

The coexistence of DCIS, lymph node pathologic stage, tumor location, and adjuvant chemotherapy were independent prognostic factors for disease-free survival.

Sep 24, 2026

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