Clinical Significance of LINC00261 in the Pathogenesis of Pancreatic, Colorectal, Hepatocellular, and Gallbladder Cancer - Review

Sep 23, 2026

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Pancreatic, colorectal, hepatocellular, and gallbladder cancers represent close to one-fifth of global cancer cases, yet effective biomarkers and therapeutic targets remain insufficient. Early diagnosis and timely treatment are essential for improving outcomes. This review analyzes the mechanistic role of the lncRNA LINC00261 across these cancers, showing tumor-suppressive activity and reduced expression linked to larger tumor size, advanced TNM stage, lymphatic metastasis, and worse overall survival.

LanguageEnglish

CategoryHealthcare

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Pages24

Reading Time1 h 0 min

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Introduction

Clinical significance and rationale

Abstract

Mechanistic roles of LINC00261

Keywords

Review Clinical Significance of LINC00261 in the Pathogenesis of Pancreatic, Colorectal, Hepatocellular, and Gallbladder Cancer Sanjana Bana 1,†, Sia Daffara 1,†, Aastha Dagar 1, Ashutosh Kumar Tiwari 1, Kanupriya Medhi 1, Sagarika Mukherjee 1, Vivek Uttam 1, Md Rizwan Ansari 2, Hardeep Singh Tuli 3, Vikas Yadav 4, * and Aklank Jain 1, * Academic Editor: Christian Barbato Received: 19 January 2025 Revised: 13 March 2025 Accepted: 17 March 2025 Published: 20 March 2025 Citation: Bana, S.; Daffara, S.; Dagar, A.; Tiwari, A.K.; Medhi, K.; Mukherjee, S.; Uttam, V.; Ansari, M.R.; Tuli, H.S.; Yadav, V.; et al. Clinical Significance of LINC00261 in the Pathogenesis of Pancreatic, Colorectal, Hepatocellular, and Gallbladder Cancer. Diseases 2025, 13, 89. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)diseases13030089 Copyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) . 1 Non-Coding RNA and Cancer Biology Lab, Department of Zoology, Central University of Punjab, Ghudda, Bathinda 151401, Punjab, India; [sanjanabana@gmail.com](sanjanabana@gmail.com) (S.B.); [siadaffara@gmail.com](siadaffara@gmail.com) (S.D.); [aasthadagar2000@gmail.com](aasthadagar2000@gmail.com) (A.D.); [ashutoshlokesh@gmail.com](ashutoshlokesh@gmail.com) (A.K.T.); [priyamedhi14@gmail.com](priyamedhi14@gmail.com) (K.M.); [sagarikamukherjee444@gmail.com](sagarikamukherjee444@gmail.com) (S.M.); [vivekuttam52@gmail.com](vivekuttam52@gmail.com) (V.U.) 2 GD Research Center, 3rd Floor, Jyoti Pinnacle Building, Survey No.11, Kondapur Village, Serilingampally Mandal, Ranga Reddy District, Hyderabad 500081, Telangana, India; [rizwanindia@gmail.com](rizwanindia@gmail.com) [3](3 Department of Bio-Sciences and Technology)[ Department of Bio-Sciences and Technology](3 Department of Bio-Sciences and Technology), [Maharishi Markandeshwar](Maharishi Markandeshwar) ([Deemed to be University](Deemed to be University)), Mullana, Ambala 133207, Haryana, India; [hardeep.biotech@gmail.com](hardeep.biotech@gmail.com) 4 Department of Translational Medicine, Clinical Research Centre, Skåne University Hospital, Lund University, 20213 Malmö, Sweden * [Correspondence: vikas.yadav@med.lu.se](Correspondence: vikas.yadav@med.lu.se) (V.Y.); [aklankjain@gmail.com](aklankjain@gmail.com) (A.J.)† These authors contributed equally to this work. Abstract: Pancreatic (PC), colorectal (CRC), hepatocellular (HCC), and gallbladder (GC) cancers together account for nearly 20% of all cancer cases. However, specific biomarkers and therapeutic targets for these cancers are lacking. Diagnosing these cancers early and providing timely, appropriate treatment to improve patient outcomes is crucial. In this context, previous studies, including ours, have highlighted the potential of non-coding RNAs, particularly long non-coding RNAs (lncRNAs), in diagnosing and prognosis of various cancers. This review focuses on the mechanistic role of the recently identified lncRNA LINC00261 in PC, CRC, HCC, and GC. Our comprehensive literature analysis revealed that LINC00261 functions as a tumor suppressor, and its reduced expression is associated with larger tumor size, advanced tumor-node-metastasis (TNM) stages, lymphatic metastasis, and poorer overall survival rates. Additionally, we discovered that LINC00261 acts as a molecular sponge for miRNAs, such as miR-550a-3p, miR-23a-3p, miR-148a, miR- 324-3p, and miR-105-5p, regulating critical cancer-related signaling pathways, including PI3K/Akt/mTOR, Protein kinase B, and Mammalian target of rapamycin (mTOR) . Further bioinformatic analysis revealed that LINC00261 regulates key cellular processes, such as protein-DNA complex formation, ribon

FAQs

What cancer types are discussed in this review?

The review covers pancreatic cancer (PC), colorectal cancer (CRC), hepatocellular cancer (HCC), and gallbladder cancer (GC).

Why are biomarkers and therapeutic targets important for these cancers?

The document states that specific biomarkers and therapeutic targets are lacking, making early diagnosis and timely, appropriate treatment crucial to improve patient outcomes.

How does LINC00261 relate to tumor development in these cancers?

LINC00261 is described as a tumor suppressor, with reduced expression associated with larger tumors, advanced TNM stages, lymphatic metastasis, and poorer overall survival.

Sep 23, 2026

Uploaded by Rowan