CircRNA_ 036186 mediates HNSCC progression by regulating 14-3-3z

Sep 21, 2026

CircRNA_ 036186 mediates HNSCC progression by regulating 14-3-3z through a circRNA–miRNA–mRNA regulatory axis. Head and neck squamous cell carcinoma (HNSCC) is a prevalent, lethal malignancy, and identification of new biomarkers is critical for diagnosis and outcome prediction. Cancerous and matched non-cancerous tissues from five patients were profiled by high-throughput sequencing, and candidate interactions were predicted using bioinformatics tools. CircRNA_ 036186 was found to regulate 14-3-3z expression via miR-193b-5p, supporting potential biomarker and therapeutic value.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages12

Reading Time30 min

AccessFree to download

Introduction

HNSCC background and need for biomarkers

Roles of 14-3-3 family and 14-3-3z

Functions of miRNA and circRNA

Study aim

Methods

Patient tissue collection and sequencing

Prediction of circRNA–miRNA–mRNA interactions

Results

Elevated 14-3-3z expression in HNSCC

Discussion

TYPE Original Research PUBLISHED 03 December 2024 DOI 10.3389/fonc.2024.1498139 OPEN ACCESS EDITED BY Sharon R. Pine, University of Colorado, United States REVIEWED BY Hui Wang, University of California, Los Angeles, United States Hongran Qin, Mayo Clinic, United States *CORRESPONDENCE Wenlong Wang [wwlkqwk@163.com](wwlkqwk@163.com)[ ](wwlkqwk@163.com)Xiangrui Ma [maxiang851225@bzmc.edu.cn](maxiang851225@bzmc.edu.cn) †These authors have contributed equally to this work RECEIVED 18 September 2024 ACCEPTED 13 November 2024 PUBLISHED 03 December 2024 CITATION Tang J, Yu D, Song J, Li J, Zhang Y, Ma X and Wang W (2024) CircRNA_ 036186 mediates HNSCC progression by regulating 14-3-3z. Front. Oncol. 14:1498139 . doi: 10.3389/fonc.2024.1498139 COPYRIGHT © 2024 Tang, Yu, Song, Li, Zhang, Ma and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. CircRNA_ 036186 mediates HNSCC progression by regulating 14-3-3z Juan Tang1,2†, Donglin Yu1,2†, Jiaojiao Song 3, Junfei Li 1,2, Yijuan Zhang 4, Xiangrui Ma 1,2* and Wenlong Wang 1,2* 1 Department of Oral and Maxillofacial Surgery, Binzhou Medical University Hospital, Binzhou, China, 2School of Stomatology, Binzhou Medical University, Yantai, China, 3 Plantation Center, Weihai Stomatological Hospital, Weihai, China, 4 Department of Anesthesiology, Binzhou Medical University Hospital, Binzhou, China Introduction: Head and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal malignancy, accounting for 95% of head and neck cancers. Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activating protein ZETA (14-3- 3z) is central to various signalling pathways and is pivotal in tumour progression. Methods: Cancerous and corresponding non-cancerous tissue samples were collected from ﬁve patients diagnosed with HNSCC. circRNA and mRNA expression proﬁles were analyzed using high-throughput sequencing techniques. Potential circRNA-microRNA (miRNA)-mRNA interactions were predicted using bioinformatics tools. Results: The study found that CircRNA_ 036186 regulates the expression of 14- 3-3z in HNSCC through miR-193b-5p. Discussion: These ﬁndings suggest that CircRNA_ 036186 has the potential to bea biomarker and therapeutic target for HNSCC and provide some theoretical basis for further research on the role of circRNA in HNSCC. KEYWORDS head and neck squamous cell carcinoma, bioinformatics analysis, high throughput sequencing technology, CircRNA, MiRNA, 14-3-3z Introduction Head and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal malignancy, accounting for 95% of head and neck cancers. The presence of numerous essential structures, including muscles, bones, blood vessels, and nerves, in the head and neck area presents a signiﬁcant challenge to eradicating the disease using conventional Frontiers in Oncology 01 [frontiersin.org](frontiersin.org) methods, such as surgery, chemotherapy, and radiotherapy. Patients with HNSCC experience a notable decline in their quality of life and mental health (1, 2) . Consequently, identifying novel potential biomarkers is paramount for diagnosing, treating, and predicting outcomes in patients with HNSCC. The 14-3-3 protein is a highly conserved family of molecules. Tissues demonstrate independent subtype-speciﬁc functions with seven distinct subtypes (b, g, e, h, s, q, and z), each of which is localised in tissues with independent subtype-speciﬁc functions (3) . The tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activating protein ZETA (14-3-3z or YWHAZ) is a member of the 1

FAQs

What is the study’s main focus in HNSCC?

The study focuses on how circRNA contributes to HNSCC progression by regulating 14-3-3z.

How was CircRNA_ 036186 linked to 14-3-3z?

The work used high-throughput sequencing and bioinformatics prediction, finding that CircRNA_ 036186 regulates 14-3-3z via miR-193b-5p.

Why is identifying biomarkers important for HNSCC patients?

HNSCC has a poor prognosis and affects patients’ quality of life and mental health, so novel biomarkers are needed for diagnosis, treatment planning, and outcome prediction.

Sep 21, 2026

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