CIRBP mRNA level in breast cancer is associated with HIF1α gene expression and microvascular density

Q: What was the study’s main objective regarding CIRBP and HIF1α?

To assess whether CIRBP is involved in increasing the stability of HIF1α mRNA and to examine CIRBP and HIF1α mRNA levels in breast tumor tissues, focusing on their gene-expression relationship with tumor microvascular density.

Q: What were the key findings in breast cancer tissue compared with surrounding normal tissue?

CIRBP and HIF1α gene expression were significantly upregulated in breast cancer samples, and this upregulation was associated with various clinicopathologic features.

Q: How are CIRBP mRNA, HIF1α mRNA, and microvascular density (MVD) related?

The study reports a correlation between CIRBP mRNA expression and HIF1α mRNA expression, and both are correlated with tumor microvascular density (MVD).

Q: What does the study suggest about CIRBP’s role in breast cancer?

It suggests CIRBP may promote angiogenesis in breast cancer based on its associations with HIF1α expression and microvascular density.

Sep 23, 2026

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Objective: The study examines whether cold-inducible RNA-binding protein (CIRBP) influences hypoxia-inducible factor 1-alpha (HIF1α) mRNA stability and evaluates CIRBP and HIF1α mRNA levels in breast tumor tissues. Results: CIRBP and HIF1α gene expression are significantly upregulated in breast cancer samples versus surrounding normal tissues, with associations to clinicopathologic features. Findings show correlations among CIRBP mRNA, HIF1α mRNA, and microvascular density (MVD), suggesting CIRBP may promote angiogenesis in breast cancer.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages9

Reading Time23 min

AccessFree to download

Abstract

Results

Introduction

Angiogenesis and HIF-1α in breast cancer

CIRBP biology and potential mechanisms

Licensing and open access information

Monjezi et al. BMC Research Notes (2025) 18:202 [https://doi.org/10.1186/s13104-025-07265-5](https://doi.org/10.1186/s13104-025-07265-5) BMC Research Notes RESEARCH NOTE Open Access CIRBP mRNA level in breast cancer is associated with HIF1α gene expression and microvascular density Sajad Monjezi 1,4, Vahid Soleimani2, Maryam Cheraghzadeh 1, Saeed Ghanbari3 and Maryam Adelipour 1,4* Abstract Objective Based on the available evidence, the cold-inducible RNA-binding protein (CIRBP) appears to play a role in increasing the stability of hypoxia-inducible factor 1-alpha (HIF1α) mRNA. This research aimed to examine the levels of CIRBP and HIF1α mRNA within breast tumor tissues and explore the relationship between their gene expression and tumor Microvascular density (MVD) . Results The results revealed a significant upregulation of CIRBP (5 . 07-fold) and HIF1α (4 . 5-fold) gene expression in BC samples compared to the surrounding normal tissues (p < 0. 001) . This upregulation was also associated with various clinicopathologic features. Furthermore, there was a correlation between CIRBP mRNA expression, HIF1α mRNA expression, and MVD. Consequently, this study suggests that CIRBP may have a role in promoting angiogenesis in BC. Keywords Breast cancer, Microvascular density, Gene expression Introduction Breast cancer (BC) is currently considered the most common cancer in women, with 23.6 new cases per 100,000 [1]. In recent times, a multitude of research endeavors have been undertaken to pinpoint novel biomarkers facilitating early detection and treatment monitoring in BC [2–4]. Therefore, a deeper understanding of the fundamental mechanisms at play in BC can significantly contribute to the discovery of these new biomarkers. *Correspondence: Maryam Adelipour [adelimaryam@rocketmail.com](adelimaryam@rocketmail.com); [adelipour-m@ajums.ac.ir](adelipour-m@ajums.ac.ir)[ ](adelipour-m@ajums.ac.ir)1Department of Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 2Department of Pathology, School of Medicine, Cancer Institute, Tehran University of Medical Science, Tehran, Iran 3Department of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 4Cellular and molecular research center, Medical Basic Science Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Angiogenesis, the formation of new blood vessels, is crucial for tumor growth and metastasis. Normally, it is regulated by a balance of pro-angiogenic and anti-angiogenic factors. In cancer, this balance is disrupted, leading to new blood vessel formation [5, 6]. Studies has shown that hypoxia-inducible factor 1α (HIF-1α) can directly stimulate the expression of specific angiogenic factors, such as vascular endothelial growth factor (VEGF), thus facilitating the formation of new blood vessels [7]. Notably, local hypoxia is known to occur during the early stages of BC development. In hypoxic conditions, there is a potential elevation in HIF-1α expression within tumor cells, subsequently promoting VEGF-induced angiogenesis [5]. It is important to emphasize the role of local hypoxia during the initial phases of breast cancer development, as it fosters a microenvironment that supports the upregulation of HIF1α and the subsequent induction of VEGF-mediated angiogenesis, which, in turn, drives tumor advancement, invasion, and metastasis [8]. © The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted ma

FAQs

What was the study’s main objective regarding CIRBP and HIF1α?

To assess whether CIRBP is involved in increasing the stability of HIF1α mRNA and to examine CIRBP and HIF1α mRNA levels in breast tumor tissues, focusing on their gene-expression relationship with tumor microvascular density.

What were the key findings in breast cancer tissue compared with surrounding normal tissue?

CIRBP and HIF1α gene expression were significantly upregulated in breast cancer samples, and this upregulation was associated with various clinicopathologic features.

How are CIRBP mRNA, HIF1α mRNA, and microvascular density (MVD) related?

The study reports a correlation between CIRBP mRNA expression and HIF1α mRNA expression, and both are correlated with tumor microvascular density (MVD).

What does the study suggest about CIRBP’s role in breast cancer?

It suggests CIRBP may promote angiogenesis in breast cancer based on its associations with HIF1α expression and microvascular density.

Sep 23, 2026

Uploaded by Callum