Chronic active and atrophic gastritis as significant contributing factor to the development of gastric cystica profunda

Sep 21, 2026

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Gastric cystica profunda (GCP) is an uncommon gastric lesion with underestimated burden due to its precancerous potential. Besides previous mucosal injury from operations, biopsy, or polypectomy, chronic active and atrophic gastritis can also promote GCP development. Careful endoscopic examination with biopsies from susceptible regions helps determine atrophy stage. Chronic atrophic gastritis increases cancer evolvement risk and contributes to GCP formation. Endoscopic resection offers an effective, minimally invasive treatment for GCPs.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages4

Reading Time10 min

AccessFree to download

Abstract

Introduction

Pathogenesis and clinical significance

Diagnostic considerations and follow-up

Role of endoscopic procedures

| W | J | G | World Journal of
Gastroenterology | | --- | --- | --- | --- | Submit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2024 May 7; 30(17): 2308-2310 DOI: 10.3748/wjg.v30.i17.2308 ISSN 1007-9327 (print) ISSN 2219-2840 (online) EDITORIAL Chronic active and atrophic gastritis as significant contributing factor to the development of gastric cystica profunda Veronika Papp, Pál Miheller Specialty type: Gastroenterology and hepatology Provenance and peer review: Invited article; Externally peer reviewed. Peer-review model: Single blind Peer-review report’s classification Scientific Quality: Grade B Novelty: Grade A Creativity or Innovation: Grade B Scientific Significance: Grade B P-Reviewer: Gao F, China Received: February 18, 2024 Revised: March 20, 2024 Accepted: April 15, 2024 Published online: May 7, 2024 Veronika Papp, Pál Miheller, Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, Budapest 1082, Hungary Corresponding author: Veronika Papp, MD, PhD, Adjunct Professor, Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, 78 Üllői Street, Budapest 1082, [Hungary.](Hungary. papp.veronika@semmelweis.hu)[ papp.veronika@semmelweis.hu](Hungary. papp.veronika@semmelweis.hu) Abstract Gastric cystica profunda (GCP) is an uncommon but underestimated gastric lesion. Its precancerous potential determines its significance. In addition to previous mucosa injury due to operations, biopsy or polypectomy, chronic active and atrophic gastritis may also lead to the development of GCPs. By carefully examining the stomach and taking biopsy samples from the susceptible regions, the stage of atrophy can be determined. Chronic atrophic gastritis is a risk factor for cancer evolvement and it can also contribute to GCPs formation. GCPs frequently occur close to early gastric cancers (EGCs) or EGC can arise from the cystic glands. Endoscopic resection is an effective and minimally invasive treatment in GCP. Key Words: Gastric cystica profunda; Chronic active gastritis; Atrophic gastritis; Operative Link for Gastritis Assessment staging; Early gastric cancer; Endoscopic resection ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. Core Tip: Gastric cystica profunda (GCP) is a premalignant lesion developing on basis of ischemia. Chronic active or atrophic gastritis are considered to be a significant etiological factors in the development of GCPs and carry a risk for cancer formation. GCPs, with or without early gastric cancer, can be removed effectively by endoscopic resection. Citation: Papp V, Miheller P. Chronic active and atrophic gastritis as significant contributing factor to the development of gastric cystica profunda. World J Gastroenterol 2024; 30(17): 2308-2310 URL: [https://www.wjgnet.com/1007-9327/full/v30/i17/2308.htm](https://www.wjgnet.com/1007-9327/full/v30/i17/2308.htm) DOI: [https://dx.doi.org/10.3748/wjg.v30.i17.2308](https://dx.doi.org/10.3748/wjg.v30.i17.2308) WJG [https://www.wjgnet.com](https://www.wjgnet.com) 2308 May 7, 2024 Volume 30 Issue 17 Papp V et al. Chronic gastritis and GCP development INTRODUCTION In this editorial we comment on the article by Geng et al [1] published in the recent issue of the World Journal of Gastroenterology. Gastric cystica profunda (GCP) is a rare gastric lesion characterized by poor clinical symptoms and mostly unremarkable endoscopic features. Therefore, the incidence of a polypoid cystic ectasia of the gastric glands is underestimated [2] . It’s pathomechanism remains obscure. A prior stomach operations, biopsy, or polypectomy can cause the development of GCP. In contrast, mucosa damage or ischaemia are factors that commonly manifest in chronic active andatrophic gastritis. Carcinoma cascade is well known since the last decade, intestinal metaplasia occurs following t

FAQs

What is gastric cystica profunda (GCP) and why is it clinically significant?

GCP is an uncommon gastric lesion with a precancerous potential, making it important despite often subtle clinical symptoms and endoscopic findings.

How do chronic active and atrophic gastritis contribute to GCP development?

The article states that, in addition to prior mucosal injury from procedures, chronic active and atrophic gastritis can lead to the development of GCPs.

How can atrophy stage in gastritis be determined in the context of GCP?

By carefully examining the stomach and taking biopsy samples from susceptible regions, the stage of atrophy can be determined.

Sep 21, 2026

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