Characterization of individuals fulfilling clinical criteria for limbic-predominant age-related TDP43 encephalopathy (LATE) in a tertiary memory clinic

Sep 30, 2026

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Limbic-predominant age-related TDP-43 encephalopathy (LATE) clinically mimics and often co-occurs with Alzheimer’s disease (AD). This study applies newly proposed LATE expert consensus diagnostic criteria in a tertiary memory clinic cohort. Participants aged over 50 from the Amsterdam Dementia Cohort were classified as Probable LATE, Possible LATE, Possible LATE-AD, or AD based on clinical, radiological, and biomarker profiles. Cognitive decline, atrophy, and mortality were analyzed using linear mixed-effects and Cox proportional hazards models.

LanguageEnglish

CategoryHealthcare

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Pages5

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DOI: 10. 1002/alz70856_104809 BIOMARKERS PODIUM PRESENTATION BIOMARKERS (NON-NEUROIMAGING) Characterization of individuals fulfilling clinical criteria for limbic-predominant age-related TDP43 encephalopathy (LATE) in a tertiary memory clinic Colin Groot 1 Ismael Luis Calandri2, 3 Hannah de Bruin 1, 6 Maria Carrigan7 Ilse Bader4 Suzie Kamps4 Diana I. Bocancea5 Lotte A. de Koning3, 8 Sophie E. Mastenbroek3, 9 Roos M. Rikken3, 8 Bastiaan G J van Tol 10 Marie R. Vermeiren11 Alex J. Wesseling 12 Ye Xia 13 Charlotte E. Teunissen 1, 14 Elsmarieke van de Giessen 15 Frederik Barkhof 16 Laura E. Jonkman4 Sven J van der Lee 17 Casper de Boer 18 Annemieke J. M. Rozemuller 19 Floor Duits20 Betty M. Tijms20 Wiesje M. van der Flier21 Yolande A. L. Pijnenburg22 Emma M. Coomans23 Rik Ossenkoppele24 1Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Netherlands 2 Fleni, CABA, Buenos Aires, Netherlands 3Amsterdam Neuroscience, Brain Imaging, Amsterdam, Netherlands 4Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Netherlands 5Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands 6 Institute for Stroke and Dementia Research, Klinikum der Ludwig-Maximilians Universität München, Munich, Germany 7Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, North Holland, Netherlands 8 Radiology & Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Netherlands 9 Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden 10 Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Abstract Background: Limbic-predominant age-related TDP-43 encephalopathy (LATE) clinically mimics and often co-occurs with Alzheimer’s disease (AD). Expert consensus criteria have been proposed for the LATE clinical diagnosis, integrating clinical and radiological features, and AD biomarkers. Here, we applied the newly proposed criteria in a tertiary memory clinic population. Method: We included participants from the Amsterdam Dementia Cohort aged >50 years who received a diagnosis of MCI or dementia between1997-2024. Following the LATE consensus criteria scheme (Figure 1), we categorized participants as “Probable LATE”,“Possible LATE” or “Possible LATE-AD”(i.e. LATE clinical and radiological profile with AD biomarker profile). Participants not fulfilling criteria for LATE but fulfilling NIA-AA criteria for AD were categorized as AD. We compared the LATE groups with AD on cognitive decline (N = 1046, N Mean time=2. 7[1.8] years) and atrophy (N = 208, Mean time=2. 1[1.6]) using linear-mixed effects models, and on mortality rates using Cox proportional hazard models. Result: Of the 3367 individuals, 1920 were classified into one of the four groups. Fiftyone (1.5%) were classified as Probable LATE, 102 (3.0%) as Possible LATE, 122 (3.6%) as Possible LATE-AD, and 1645 (48.8%) as AD (Table 1). Compared to AD, Probable This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2025 The Alzheimer’s Association. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association. Alzheimer’s Dement. 2025;21(Suppl. 2):e104809. [https://doi.org/10.1002/alz70856_104809](https://doi.org/10.1002/alz70856_104809) wi[leyonlinelibrary.com/journal/alz](leyonlinelibrary.com/journal/alz) 1of5 Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Stockholmslän, Sweden 11 Department of Radiology & Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands 12Amsterdam UMC, location VUm

FAQs

What is the purpose of applying the LATE consensus criteria in this study?

To test the newly proposed expert consensus diagnostic criteria for LATE within a tertiary memory clinic population and categorize individuals based on clinical, radiological, and AD biomarker profiles.

How were participants categorized into Probable LATE, Possible LATE, Possible LATE-AD, and AD?

Participants meeting the LATE consensus scheme were grouped as Probable LATE, Possible LATE, or Possible LATE-AD (LATE clinical/radiological profile plus AD biomarker profile). Participants not fulfilling LATE criteria but meeting NIA-AA AD criteria were categorized as AD.

What outcomes were compared across groups?

Cognitive decline and atrophy were compared using linear mixed-effects models, and mortality rates were compared using Cox proportional hazard models.

Sep 30, 2026

Uploaded by Fahsai