Can neutrophil-lymphocyte ratio and mean platelet volume be used to predict metastasis in individuals with lung cancer?

Sep 24, 2026

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Chronic inflammation drives the etiopathogenesis of many life-threatening diseases, including cancer, yet the mechanisms linking inflammation to cancer progression remain incompletely defined and the clinical value of inflammatory markers is uncertain. This retrospective cross-sectional study assessed whether neutrophil-lymphocyte ratio (NLR) and mean platelet volume (MPV) can indicate metastasis in lung cancer patients admitted between January 2019 and February 2020.

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CategoryHealthcare

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Abstract

Introduction

® Observational Study Can neutrophil-lymphocyte ratio and mean platelet volume be used to predict metastasis in individuals with lung cancer? Yasemin Kılıç Öztürk, MDa,* , Hande İleri, MDb , Burcu Şen Şahin, MDc , Merve Dağcı, MDd | Abstract
Chronic inflammation plays an important role in the etiopathogenesis of many life-threatening chronic diseases, including cancer. Currently, the relationship between inflammation, native immunity and cancer is widely accepted; however, many of the mechanisms mediating this relationship remain undetermined and the clinical significance of these markers is unclear. The purpose of this study was to investigate the potential of neutrophil-lymphocyte ratio (NLR) and mean platelet volume (MPV) to indicate the existence of metastasis in lung cancer. This retrospective cross-sectional study evaluated patients with lung cancer of any pathological type who was admitted to the Palliative Care Unit of the referral hospital in the region between January 2019 and February 2020. Patient characteristics, distant organ metastasis, treatments, NLR and MPV values were noted. Patients were grouped as with or without metastasis. Characters, NLR, MPV values were compared. One hundred twenty-six patients were included. The mean age of the patients was 61.17 ± 9.4 years and 7.9%(n = 10) were female. The patients with a history of chemotherapy were 47%(n = 60) and distant organ metastases were present in 38.9%(n = 49) of the patients. The mean MPV value of 49 patients with distant metastasis was 8.34 ± 0.8 fL. MPV values of those with metastasis were found to be significantly higher than those without (P = .010) . There was no significant difference in NLR values between groups (P = .920) . Lung cancer patients with metastasis were found with higher MPV values. MPV can be effective and most accessible test in prediction of metastasis in lung cancer patients regardless of the pathological type. | | --- | | Abbreviations: MPV = mean platelet volum, NLR = neutrophil-lymphocyte ratio, ROC = receiver-operating characteristics. | | Keywords: lung cancer, mean platelet volume, metastasis, neutrophil/lymphocyte ratio | 1. Introduction L[1,u2]ngIn csancpiteeifstedelthopemmestts ipnrevtraeentmtecant,ntcehspogrlnwsif. patients with lung cancer remains poor with a 5-year survival rate of under 15% .[3,4] The chronic inflammation plays an important role in theetiopathogenesis of many life-threatening chronic diseases, including cancer.[5] Tumors modulate the inflammatory response by the secretion of growth factors and chemo-attractant which suppress anti-cancer T cell responses. [6] The inflammatory markers are being studied to predict the course and severity of chronic diseases. Neutrophils play a major role in tumor angiogenesis through the production of proangiogenic factors, which leads to the adhesion and seeding of metastasis. [7,8] In current studies, it is defined that the total white blood cell count and its subtypes count and their ratio The authors have no funding and conflicts of interest to disclose. The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request. The study was conducted in accordance with the Declaration of Helsinki, and the protocol was approved by Tepecik Education and Research Hospital ethics committee (2021/05-10) Part of our data was presented as poster presentation in 7. Ulusal İSTAHEDAile Hekimliği Kongresi-İKON 2020 a University of Health Sciences Turkey Izmir Faculty of Medicine, Tepecik Health Practices and Research Center, Family Medicine, Izmir, Turkey, b Tepecik Training and Research Hospital, Family Medicine, Izmir, Turkey, c Menteşe Community Health Center, Muğla, Turkey, d Havza Çarşı Family Health Center, Samsun, Turkey. * Correspondence: Yasemin Kılıç Öztürk, University of Health Sciences Turkey Izmir Faculty of Medicine, Tepecik Health Practices and Research Center, Family t

FAQs

What was the study’s main purpose in lung cancer patients?

To investigate whether neutrophil-lymphocyte ratio (NLR) and mean platelet volume (MPV) can indicate the presence of metastasis in lung cancer.

How were patients grouped for analysis?

Patients were grouped into those with metastasis and those without metastasis, and demographic and marker values were compared between groups.

Which marker showed a significant association with metastasis?

MPV values were significantly higher in patients with metastasis, while NLR showed no significant difference between groups.

Sep 24, 2026

Uploaded by Himbo