Bibliometric analysis of phosphoglycerate kinase 1 expression in breast cancer and its distinct upregulation in triple-negative breast cancer

Q: What is the study’s primary focus regarding PGK1 in breast cancer?

The study evaluates PGK1 as a possible biomarker by analyzing breast cancer research status and comparing PGK1 expression and mechanisms among TNBC, non-TNBC, and normal breast tissue.

Q: How were bibliometric and expression analyses performed?

Relevant literature was downloaded from the Web of Science Core Collection, and publication counts, keyword frequency, cooperation networks, and theme trends were analyzed. Normal, TNBC, and non-TNBC mRNA datasets were compiled to identify differentially expressed genes.

Q: What does the study conclude about PGK1 in TNBC?

PGK1 expression is identified as a research hotspot and frontier direction, and PGK1 is suggested to promote TNBC progression by mediating metabolism and HIF-1 signaling pathways.

Sep 21, 2026

Uploaded by Noah

Phosphoglycerate kinase 1 (PGK1) is examined as a potential biomarker in breast cancer, with particular focus on its expression differences and underlying mechanisms in triple-negative breast cancer (TNBC). Research status and expression profiles are compared across TNBC, non-TNBC, and normal breast tissue using bibliometrics from Web of Science and integrated bioinformatic analyses. Publication trends, keyword frequency, cooperation networks, differential gene and pathway enrichment, diagnostic performance, and prognostic significance are evaluated alongside protein-protein interaction and hub gene identification.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages29

Reading Time1 h 13 min

AccessFree to download

Abstract

Background

Aim

Methods

Results

Conclusion

Main Text Highlights

| W | J | C | O | World Journal of
Clinical Oncology | | --- | --- | --- | --- | --- | Submit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Oncol 2024 July 24; 15(7): 867-894 DOI: 10.5306/wjco.v15.i7.867 ISSN 2218-4333 (online) ORIGINAL ARTICLE Clinical and Translational Research Bibliometric analysis of phosphoglycerate kinase 1 expression in breast cancer and its distinct upregulation in triple-negative breast cancer Jing-Yu Chen, Jian-Di Li, Rong-Quan He, Zhi-Guang Huang, Gang Chen, Wen Zou Specialty type: Oncology Provenance and peer review: Unsolicited article; Externally peer reviewed. Peer-review model: Single blind Peer-review report’s classification Scientific Quality: Grade B Novelty: Grade B Creativity or Innovation: Grade B Scientific Significance: Grade B P-Reviewer: Uz Zaman M Received: February 8, 2024 Revised: May 27, 2024 Accepted: June 24, 2024 Published online: July 24, 2024 Processing time: 158 Days and 20.5 Hours Jing-Yu Chen, Jian-Di Li, Zhi-Guang Huang, Gang Chen, Wen Zou, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China Rong-Quan He, Department of Medical Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China Corresponding author: Wen Zou, MM, Doctor, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, [China.](China. pathologyzw@sr.gxmu.edu.cn)[ pathologyzw@sr.gxmu.edu.cn](China. pathologyzw@sr.gxmu.edu.cn) Abstract BACKGROUND Phosphoglycerate kinase 1 (PGK1) has been identified as a possible biomarker for breast cancer (BC) and may play a role in the development and advancement of triple-negative BC (TNBC) . AIM To explore the PGK1 and BC research status and PGK1 expression and mechanism differences among TNBC, non-TNBC, and normal breast tissue. METHODS PGK1 and BC related literature was downloaded from Web of Science Core Collection Core Collection. Publication counts, key-word frequency, cooperation networks, and theme trends were analyzed. Normal breast, TNBC, and nonTNBC mRNA data were gathered, and differentially expressed genes obtained. Area under the summary receiver operating characteristic curves, sensitivity and specificity of PGK1 expression were determined. Kaplan Meier revealed PGK1’s prognostic implication. PGK1 co-expressed genes were explored, and Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Disease Ontology applied. Protein-protein interaction networks were constructed. Hub genes identified. RESULTS PGK1 and BC related publications have surged since 2020, with China leading the way. The most frequent keyword was “Expression”. Collaborative networks were found among co-citations, countries, institutions, and authors. PGK1 expression WJCO [https://www.wjgnet.com](https://www.wjgnet.com) 867 July 24, 2024 Volume 15 Issue 7 Chen JY et al. PGK1 in TNBC and BC progression were research hotspots, and PGK1 expression and BC survival were research frontiers. In 16 TNBC vs non-cancerous breast and 15 TNBC vs non-TNBC datasets, PGK1 mRNA levels were higher in 1159 TNBC than 1205 non-cancerous breast cases [standardized mean differences (SMD): 0.85, 95% confidence interval (95%CI): 0.54-1.16, I² = 86%, P < 0.001] . PGK1 expression was higher in 1520 TNBC than 7072 non-TNBC cases (SMD: 0.25, 95%CI: 0.03-0.47, I² = 91%, P = 0.02) . Recurrence free survival was lower in PGK1-high-expression than PGK1-low-expression group (hazard ratio: 1.282, P = 0.023) . PGK1 co-expressed genes were concentrated in ATP metabolic process, HIF-1 signaling, and glycolysis/gluconeogenesis pathways. CONCLUSION PGK1 expression is a research hotspot and frontier direction in the BC field. PGK1 may play a strong role in promoting

FAQs

What is the study’s primary focus regarding PGK1 in breast cancer?

The study evaluates PGK1 as a possible biomarker by analyzing breast cancer research status and comparing PGK1 expression and mechanisms among TNBC, non-TNBC, and normal breast tissue.

How were bibliometric and expression analyses performed?

Relevant literature was downloaded from the Web of Science Core Collection, and publication counts, keyword frequency, cooperation networks, and theme trends were analyzed. Normal, TNBC, and non-TNBC mRNA datasets were compiled to identify differentially expressed genes.

What does the study conclude about PGK1 in TNBC?

PGK1 expression is identified as a research hotspot and frontier direction, and PGK1 is suggested to promote TNBC progression by mediating metabolism and HIF-1 signaling pathways.

Sep 21, 2026

Uploaded by Noah