Associations of cord plasma per-and polyfluoroalkyl substances (PFAS) with neonatal and child body composition and adiposity - The GUSTO study

Sep 15, 2026

Uploaded by James

Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and its impact on early growth and later adiposity remains uncertain, particularly for newer short-chain replacement PFAS. In the GUSTO multi-ethnic Singaporean mother-offspring cohort, concentrations of 12 PFAS were measured in 783 cord plasma samples, and neonatal body composition, metabolic indicators, and MRI-derived abdominal adiposity (subset) were assessed at birth and age 6. Individual PFAS, chain categories, and principal-component scores were modeled using multivariable linear regression adjusted for key maternal factors.

LanguageEnglish

CategoryResearch & Report

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Pages13

Reading Time33 min

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[https://helda.helsinki.fi](https://helda.helsinki.fi) Associations of cord plasma per-and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity : The GUSTO study Chen, Ling Wei; Ng, Sharon; Tint, Mya Thway; Michael, Navin; Sadananthan, Suresh Anand 2024-01 Elsevier Ltd. [http://hdl.handle.net/10138/568838](http://hdl.handle.net/10138/568838) Chen, L W, Ng, S, Tint, M T, Michael, N, Sadananthan, S A, Ong, Y Y, Yuan, W L, Chen, Z Y, Chen, C Y, Godfrey, K M, Tan, K H, Gluckman, P D, Chong, Y S, Eriksson, J G, Yap, F, Lee, Y S, Fortier, M V, Velan, S S & Chan, S Y 2024, 'Associations of cord plasma perand polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity : The GUSTO study', Environment International, vol. 183, 108340. [https://doi.org](https://doi.org)[ ](https://doi.org)[/10.1016/j.envint.2023.108340](/10.1016/j.envint.2023.108340) Downloaded from Helda, University of Helsinki institutional repository. [https://helda.helsinki.fi](https://helda.helsinki.fi)[ ](https://helda.helsinki.fi)[This is an electronic reprint of the original article.](This is an electronic reprint of the original article.) This reprint may differ from the original in pagination and typographic detail. Please cite the original version. Environment International 183 (2024) 108340 Contents lists available at ScienceDirect Environment International journal [homepage:](homepage: www.elsevier.com/locate/envint)[ www.elsevier.com/locate/envint](homepage: www.elsevier.com/locate/envint) Full length article Associations of cord plasma per-and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity: The GUSTO study Ling-Wei Chena, b, c, Sharon Ngc, Mya-Thway Tintc, d, Navin Michael c, Suresh Anand Sadananthanc, Yi Ying Ong e, f, Wen Lun Yuan c, g, Ze-Ying Chenh, Chia-Yang Chenh, Keith M. Godfrey i, Kok Hian Tanj, k, Peter D. Gluckman c, l, Yap-Seng Chong c, m, Johan G. Eriksson c, d, m, n, o, Fabian Yapj, p, Yung Seng Lee e, q, Marielle V. Fortier r, Sendhil S. Velanc, Shiao-Yng Chan c, d, m, * a Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, No. 17 Xu-Zhou Road, Taipei 10055, Taiwan b Master of Public Health Program, College of Public Health, National Taiwan University, No. 17 Xu-Zhou Road, Taipei 10055, Taiwan c Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, 30 Medical Drive, 117609, Singapore d Human Potential Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore e Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, 119228, Singapore f Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA g Universit´e Paris Cit´e and Universit´e Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), F-75004 Paris, France h Institute of Food Safety and Health, College of Public Health, National Taiwan University, No. 17 Xu-Zhou Road, Taipei 10055, Taiwan i MRC Lifecourse Epidemiology Centre & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Tremona Road, SO16 6YD Southampton, UK j Duke-NUS Medical School, 8 College Road, 169857, Singapore k Department of Reproductive Medicine, KK Women’s and Children Hospital, Singapore, Singapore l Liggins Institute, University of Auckland, 85 Park Rd, Grafton, Auckland 1023, New Zealand m Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, 119228, Singapore n Department of General Practice and Primary Health Care, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland o Folkh¨alsan Research Center, Topeliusgatan 20, 00250 Helsin

FAQs

What is the primary focus of the GUSTO study on PFAS?

The study examines whether prenatal exposure to per- and polyfluoroalkyl substances measured in cord plasma is associated with birth size and later offspring body composition and adiposity.

How were PFAS exposures measured and modeled in the cohort?

Twelve PFAS were measured in 783 cord plasma samples using UPLC-MS/MS. Analyses modeled individual PFAS, chain categories (long- vs short-chain), and principal-component scores to capture exposure patterns.

What outcomes were used to assess associations with adiposity?

Outcomes included offspring anthropometry and other body composition/metabolic indicators at birth and age 6, with MRI-derived abdominal adiposity measured in a subset.

Sep 15, 2026

Uploaded by James