Association of CDK15 and L1CAM Expression in Cervical Cancer Tissues - Clinicopathological Characteristics and Recurrence/Metastasis After Radical Hysterectomy

Q: What is the main objective of the study?

To investigate whether CDK15 and L1CAM L1 expression correlates with clinicopathological characteristics and with recurrence and/or metastasis after radical hysterectomy in cervical cancer.

Q: How was the study conducted and what was the follow-up period?

A retrospective analysis was performed on 80 patients who underwent radical hysterectomy. Recurrence and metastasis were documented within 12 months after surgery, and Kaplan-Meier methods were used for recurrence-free survival.

Q: What did the study find about CDK15 and L1CAM expression levels?

Both CDK15 and L1CAM had higher positive expression rates in cervical cancer tissues than in adjacent non-cancerous tissues, with significant differences across selected clinicopathological subgroups.

Sep 22, 2026

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Objective: investigate the association of CDK15 and L1CAM L1 expression with clinicopathological characteristics and recurrence and/or metastasis after radical hysterectomy in cervical cancer. Methodology: retrospective analysis of 80 pathologically confirmed cervical cancer patients treated between January 2023 and January 2025; expression levels were compared across subgroups based on age and FIGO stage, and recurrence/metastasis were documented within 12 months. Kaplan-Meier analysis assessed recurrence-free survival (RFS). Results: CDK15 and L1CAM showed higher positive rates in cancer tissues than adjacent non-cancer tissues (P<0.05), with differential expression across multiple clinicopathological subgroups. RFS at 12 months was lower with positive CDK15 (P=0.019). Conclusion: CDK15 and L1CAM are highly expressed and may serve as prognostic biomarkers and therapeutic targets.

LanguageEnglish

CategoryHealthcare

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Abstract

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Introduction

Original Article Association of CDK15 and L1CAM Expression in Cervical Cancer Tissues with Clinicopathological Characteristics and Recurrence/ Metastasis After Radical Hysterectomy Jingjing Li 1, Yuanyuan Su2, Limin Chen3, Yan An4, Lin Shen5 ABSTRACT Objective: To investigate the association of CDK15(cyclin-dependent kinase 15) and L1CAM L1 (cell adhesion molecule) expression with clinicopathological characteristics and recurrence and/or metastasis after radical hysterectomy of cervical cancer. Methodology: Retrospective analysis was performed on the clinical data of 80 patients with pathologically confirmed cervical cancer who underwent radical hysterectomy at Affiliated Hospital of Hebei University between January 2023 to January 2025. Differences in CDK15 and L1CAM L1 expression in cervical cancer tissues were compared across subgroups stratified by different clinicopathological characteristics, including age and International Federation of Gynecology and Obstetrics(FIGO) stage. Recurrence and metastasis in cervical cancer patients were documented within 12 months post-radical hysterectomy. The Kaplan-Meier method was employed to analyze the association of CDK15/L1CAM expression with recurrence-free survival(RFS) . Results: The positive expression rates of CDK15 and L1CAM in cervical cancer tissues were 51.25% and 47.50%, respectively-both significantly higher than the corresponding rates of 22.50% and 18.75% in adjacent non-cancerous tissues(P<0.05) . In cervical cancer tissues, the expression of CDK15 exhibited statistically significant differences across subgroups stratified by FIGO stage, histological differentiation, lymph node metastasis, and lymphovascular invasion(P<0.05); whereas the expression of L1CAM demonstrated statistically significant differences across subgroups stratified by FIGO stage, maximum tumor diameter, and lymph node metastasis(P<0.05) . Kaplan-Meier analysis revealed that the 12 months RFS rate after radical hysterectomy was approximately 68.29% in cervical cancer patients with positive CDK15 expression, which was lower than the 89.74% in patients with negative CDK15 expression(Log-rank P=0.019) . Conclusion: CDK15 and L1CAM are highly expressed in cervical cancer tissues. Consequently, CDK15 and L1CAM hold promise as novel prognostic biomarkers and potential therapeutic targets for cervical cancer. KEYWORDS: Cervical Cancer, CDK15, Clinicopathological Characteristics, L1CAM, Recurrence and Metastasis. doi: [https://doi.org/10.12669/pjms.42.3.13277](https://doi.org/10.12669/pjms.42.3.13277) How to cite this: Li J, Su Y, Chen L, An Y, Shen L. Association of CDK15 and L1CAM Expression in Cervical Cancer Tissues with Clinicopathological Characteristics and Recurrence/Metastasis After Radical Hysterectomy. Pak J Med Sci. 2026;42(3):621-628. doi: [https://doi.org/10.12669/pjms.42.3.13277](https://doi.org/10.12669/pjms.42.3.13277) This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Note: Jingjing Li and Limin Chen are both considered as co-first authors. Correspondence: Yuanyuan Su Department of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, Baoding 071000, Hebei, China. Email: [YuanyuanSu83@126.com](YuanyuanSu83@126.com) * Received for Publication: September 08, 2025 * Revision Received: February 02, 2026 * Corrected & Edited: February 05, 2026 * Revision Accepted: * February 21, 2026 INTRODUCTION With the widespread implementation of cervical cancer screening, expanded administration of human papillomavirus (HPV) vaccines, and refinement of surgical techniques, the incidence and mortality of cervical cancer in China have exhibited a declining trend.

FAQs

What is the main objective of the study?

To investigate whether CDK15 and L1CAM L1 expression correlates with clinicopathological characteristics and with recurrence and/or metastasis after radical hysterectomy in cervical cancer.

How was the study conducted and what was the follow-up period?

A retrospective analysis was performed on 80 patients who underwent radical hysterectomy. Recurrence and metastasis were documented within 12 months after surgery, and Kaplan-Meier methods were used for recurrence-free survival.

What did the study find about CDK15 and L1CAM expression levels?

Both CDK15 and L1CAM had higher positive expression rates in cervical cancer tissues than in adjacent non-cancerous tissues, with significant differences across selected clinicopathological subgroups.

Sep 22, 2026

Upload by Taylor Morgan