Applications of leukocyte platelet-rich fibrin in oral and maxillofacial surgery - case series

Sep 29, 2026

Uploaded by James

Leukocyte platelet-rich fibrin (L-PRF) is presented as an autologous, biocompatible, low-cost regenerative material with clinical relevance in oral and maxillofacial surgery. A six-patient case series evaluates comprehensive clinical and imaging assessments followed by L-PRF-based interventions, including preparation and multiple applications. Outcomes cover soft-tissue closure, sinus lift with bone graft support, prevention of post-extraction complications, and management of recurrent pericoronitis, with favorable healing and reinforced therapeutic value.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages13

Reading Time33 min

AccessFree to download

Introduction

Objectives

Patients and Methods

Results

Conclusion

Key words

CASE SERIES STUDY [https://doi.org/10.5125/jkaoms.2025.51.6.384](https://doi.org/10.5125/jkaoms.2025.51.6.384)[ ](https://doi.org/10.5125/jkaoms.2025.51.6.384)pISSN 2234-7550 · eISSN 2234-5930 Applications of leukocyte platelet-rich fibrin in oral and maxillofacial surgery: case series Déborah Rocha Seixas1 , Isadora Molina Sanches1 , Alessandra Mazzo2 , Paulo Sergio da Silva Santos1 , Eduardo Sanches Gonçales1 1Department of Surgery, Stomatology, Pathology, and Radiology, Bauru School of Dentistry, University of São Paulo, 2Bauru Medical School, University of São Paulo, Bauru, Brazil Abstract (J Korean Assoc Oral Maxillofac Surg 2025;51:384-396) Objectives: Leukocyte platelet-rich fibrin (L-PRF) has garnered attention due to its biocompatibility, low cost, and regenerative potential. This paper presents a clinical case series demonstrating the versatility and effectiveness of L-PRF in oral and maxillofacial surgery. Patients and Methods: This case series comprised six patients who underwent comprehensive clinical and imaging evaluations and were recommended for oral surgery interventions using L-PRF. The cases include venipuncture, L-PRF preparation, and its clinical applications. Results: In Patient 1, an oroantral communication was closed using an L-PRF membrane and vestibular flap, achieving satisfactory soft-tissue healing. Patient 2 underwent a maxillary sinus lift with bone graft material and L-PRF membranes (replacing collagen membranes) to reduce cost and enhance bone regeneration. In Patients 3 to 5 (all systemically compromised), post-extraction placement of an L-PRF plug and membranes prevented complications and preserved the alveolar ridge for future rehabilitation. Finally, Patients 6 and 7, both with recurrent pericoronitis of partially erupted lower third molars, received extractions followed by L-PRF plug and membrane placement, with uneventful healing in all cases. The findings reinforce the growing body of evidence supporting the benefits of L-PRF in oral and maxillofacial surgery. Conclusion: L-PRF represents a promising, biocompatible tool in clinical practice, offering significant advantages for patient recovery and surgical outcomes. Key words: Platelet-rich fibrin, Oral surgery, Sinus floor augmentation, Tooth extraction, Phlebotomy [paper submitted 2025. 5. 31 / revised 2025. 10. 9 / accepted 2025. 10. 12] I. Introduction Platelet-rich fibrin (PRF) is an autologous fibrin matrix rich in leukocyte cytokines and platelets (thrombocytes) and represents the second generation of platelet concentrates1 . The creation of the PRF simplified the preparation of platelet concentrates since using bovine thrombin or anticoagulant is unnecessary. Since no anticoagulant is present, most of the blood sample’s platelets that come into contact with the tube Déborah Rocha Seixas Department of Surgery, Stomatology, Pathology, and Radiology, Bauru School of Dentistry, University of São Paulo, Alameda Dr. Octávio Pinheiro Brisolla, 9-75 Vila Regina, Bauru 17012-230, Brazil TEL: +55-14-3235-8000 [E-mail: deborahrocha@usp.br](E-mail: deborahrocha@usp.br) ORCID: [https://orcid.org/0000-0002-8170-8005](https://orcid.org/0000-0002-8170-8005) CC This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ([http://creativecommons.org/](http://creativecommons.org/)[ ](http://creativecommons.org/)[licenses/by-nc/4.0/](licenses/by-nc/4.0/)), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2025 The Korean Association of Oral and Maxillofacial Surgeons. walls activate within a few minutes, causing the coagulation cascades to be released2 . PRF contributes to tissue regeneration through a combination of biological mechanisms. It functions as a bioactive scaffold capable of releasing essential growth factors, such as platelet-derived growth facto

FAQs

What is the main purpose of using leukocyte platelet-rich fibrin (L-PRF) in this case series?

To demonstrate the versatility and effectiveness of L-PRF in oral and maxillofacial surgery, leveraging its biocompatibility, low cost, and regenerative potential.

How many patients were included, and what pre-treatment evaluation was performed?

Six patients were included. Each underwent comprehensive clinical and imaging evaluations before receiving oral surgery interventions using L-PRF.

What clinical applications of L-PRF are described in the results?

The series describes oroantral communication closure with L-PRF membrane, maxillary sinus lift with L-PRF replacing collagen membranes, post-extraction placement to prevent complications and preserve ridge form, and extraction plus L-PRF plug and membrane placement for recurrent pericoronitis.

Sep 29, 2026

Uploaded by James