Antiviral Shrimp lncRNA06 Possesses Anti-Tumor Activity by Inducing Apoptosis of Human Gastric Cancer Stem Cells in a Cross-Species Manner

Sep 21, 2026

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Virus infection disrupts host-cell metabolism, and such metabolic imbalance is a key driver of tumorigenesis, making antiviral molecules potential anti-tumor regulators. Long non-coding RNAs (lncRNAs) control gene expression and thereby influence metabolic programs, yet the role of antiviral lncRNAs in cancer development remains unclear. This study characterizes shrimp-derived antiviral lncRNAs and shows shrimp lncRNA06 suppresses human gastric cancer stem cells by triggering apoptosis across species.

LanguageEnglish

CategoryResearch & Report

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Abstract

Introduction

marine drugs Article Antiviral Shrimp lncRNA06 Possesses Anti-Tumor Activity by Inducing Apoptosis of Human Gastric Cancer Stem Cells in a Cross-Species Manner Ahmad Khan 1,2, Anas Mohammed 1 and Xiaobo Zhang 1, * Citation: Khan, A.; Mohammed, A.; Zhang, X. Antiviral Shrimp lncRNA06 Possesses Anti-Tumor Activity by Inducing Apoptosis of Human Gastric Cancer Stem Cells in a Cross-Species Manner. Mar. Drugs 2024, 22, 221 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)md22050221 Academic Editor: Sergey A. Dyshlovoy Received: 27 March 2024 Revised: 7 May 2024 Accepted: 13 May 2024 Published: 15 May 2024 Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) . 1 College of Life Sciences, Laboratory for Marine Biology and Biotechnology of Pilot National Laboratory for Marine Science and Technology (Qingdao), Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhejiang University, Hangzhou 310058, China; [ahmadqau19@yahoo.com](ahmadqau19@yahoo.com) (A.K.); [anas_elzein@yahoo.com](anas_elzein@yahoo.com) (A.M.) 2 Government Post Graduate College Miran Shah, Miran Shah 28200, Pakistan * Correspondence: [zxb0812@zju.edu.cn](zxb0812@zju.edu.cn); Tel.: +86-571-88981129 Abstract: Virus infection causes the metabolic disorder of host cells, whereas the metabolic disorder of cells is one of the major causes of tumorigenesis, suggesting that antiviral molecules might possess anti-tumor activities by regulating cell metabolism. As the key regulators of gene expression, long non-coding RNAs (lncRNAs) play vital roles in the regulation of cell metabolism. However, the influence of antiviral lncRNAs on tumorigenesis has not been explored. To address this issue, the antiviral and anti-tumor capacities of shrimp lncRNAs were characterized in this study. The results revealed that shrimp lncRNA06, having antiviral activity in shrimp, could suppress the tumorigenesis of human gastric cancer stem cells (GCSCs) via triggering apoptosis of GCSCs in a cross-species manner. Shrimp lncRNA06 could sponge human miR-17-5p to suppress the stemness of GCSCs via the miR-17-5p-p21 axis. At the same time, shrimp lncRNA06 could bind to ATP synthase subunit beta (ATP5F1B) to enhance the stability of the ATP5F1B protein in GCSCs, thus suppressing the tumorigenesis of GCSCs. The in vivo data demonstrated that shrimp lncRNA06 promoted apoptosis and inhibited the stemness of GCSCs through interactions with ATP5F1B and miR-17-5p, leading to the suppression of the tumorigenesis of GCSCs. Therefore, our findings highlighted that antiviral lncRNAs possessed anti-tumor capacities and that antiviral lncRNAs could be the anti-tumor reservoir for the treatment of human cancers. Keywords: antiviral lncRNA; shrimp; human gastric cancer stem cells; tumorigenesis; cross-species regulation 1. Introduction Virus infection in host cells is caused by viral and host factors and the surrounding environment. The host microbiota may enhance viral survival by improving virion stability and boosting coinfection rates [1–3] . The virus finishes its life cycle in host cells, and thus it depends on the metabolic mechanisms of living cells [4,5] . To achieve the maximum required energy and substance for the virus’s life cycle, the virus controls the metabolic homeostasis of the host cells, such as glycolysis and the pentose phosphate system [6] . Therefore, virus infection must result in the metabolic disturbance of the affected cells [5,7] . Upon sensing the invading viruses, the host cells generate some antiviral molecules, such as non-coding RNAs, secondary metabolites, and proteins, to defend against virus i

FAQs

What hypothesis links antiviral molecules to anti-tumor activity?

Virus infection causes metabolic disorder in host cells, and metabolic disorder is a major cause of tumorigenesis. Antiviral molecules may therefore counter aberrant metabolism and suppress tumor development.

How does shrimp lncRNA06 inhibit human gastric cancer stem cells?

Shrimp lncRNA06 triggers apoptosis of human gastric cancer stem cells in a cross-species manner. It also reduces stemness by sponging miR-17-5p through the miR-17-5p-p21 axis.

What molecular interactions support the anti-tumor effect in vivo?

In vivo results indicate shrimp lncRNA06 promotes apoptosis and inhibits stemness via interactions with ATP5F1B and miR-17-5p.

Sep 21, 2026

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