Antioxidant, anticancer, and anti-inflammatory potential of Moringa seed and Moringa seed oil - A comprehensive approach

Sep 21, 2026

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Moringa oleifera, known as moringa, is reviewed for its physiological benefits, particularly its reported ability to counteract carcinogenesis. The paper summarizes bioactive components from moringa seeds that show anticancer effects across multiple human cancers and describes cytotoxic actions on cancerous cells. Seed-derived extracts inhibit cancer proliferation, promote apoptosis via multiple signaling pathways, and involve increased ROS and caspase-3 activity, with related caspase activation further reducing proliferation. Broader implications include antioxidant, anti-inflammatory, and therapeutic targeting potential, plus cardiovascular and glycemic benefits through MDA reduction, SOD/GPx modulation, and mitochondrial ROS control.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages17

Reading Time43 min

AccessFree to download

Introduction

Moringa oleifera as a medicinal herb

Bioactive components and anticancer relevance

Antioxidant and anti-inflammatory mechanisms

Received: 28 July 2023 | Revised: 5 February 2024 | Accepted: 21 June 2024 DOI: 10. 1002/fsn3 .4312 RE V I E W Antioxidant, anticancer, and anti-inflammatory potential of Moringa seed and Moringa seed oil: A comprehensive approach Muhammad Shahbaz1 | Hammad Naeem1,2 | Maryam Batool1 | Muhammad Imran3 | Muzzamal Hussain4 | Ahmed Mujtaba5 | Suliman A. Alsagaby6 | Waleed Al Abdulmonem7 | Ahmed H. El-Ghorab8 | Mohammed M. Ghoneim9,10 | Mohamed E. Shaker11,12 | Mohamed A. Abdelgawad13 | Entessar Al Jbawi14 1Department of Food Science and Technology, Muhammad Nawaz Shareef University of Agriculture Multan, Multan, Pakistan 2Food Technology Section, Post-Harvest Research Centre, Ayub Agricultural Research Institute, Faisalabad, Pakistan 3 Department of Food Science and Technology, University of Narowal, Narowal, Pakistan 4Department of Food Sciences, Government College University Faisalabad, Faisalabad, Pakistan 5Department of Food Science and Technology, Faculty of Engineering and Technology, Hamdard University Islamabad Campus, Islamabad, Pakistan 6Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, AL-Majmaah, Saudi Arabia 7Department of Pathology, College of Medicine, Qassim University, Buraidah, Saudi Arabia 8 Department of Chemistry, College of Science, Jouf University, Sakaka, Saudi Arabia 9Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah, Saudi Arabia 10 Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt 11Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia 12Department of Pharmacology & Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt 13 Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia 14Syrian Arab Republic Ministry of Agriculture and Agrarian Reform, Damascus, Syria Correspondence Entessar Al Jbawi, Syrian Arab Republic Ministry of Agriculture and Agrarian Reform, Damascus, Syria. Email: [dr.entessara@gmail.com](dr.entessara@gmail.com) Muzzamal Hussain, Department of Food Sciences, Government College University Faisalabad, Faisalabad, Pakistan. [Email:](Email: muzzamalhussain24@gcuf.edu.pk)[ muzzamalhussain24@gcuf.edu.pk](Email: muzzamalhussain24@gcuf.edu.pk) Abstract Moringa oleifera, a widely recognized plant more commonly known as moringa, has obtained significant research interest in recent years due to its prospective physiological advantages, including its claimed ability to counteract carcinogenesis. The moringa plant has been found to possess bioactive components that exhibit promising anticancer activities against different human cancers, such as breast cancer, prostate cancer, pancreatic cancer, etc. The cytotoxic properties of moringa seed extracts on cancerous cells have also been provided in this paper along with other notable health benefits. The extracts derived from moringa seeds inhibit cancer proliferation and promote cancer cell apoptosis through multiple signaling pathways. They also stimulated intracellular reactive oxygen species (ROS) production and subsequently induced caspase-3 activity. The impact of moringin and avenanthramide 2f on the stimulation of caspases 2, 4, 8, and 9 results in reduction in the proliferation of cancer cells. The results reported by research studies hold significant implications for identifying and targeting specific molecular entities that could serve as potential therapeutic targets This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2024 The Author(s) . Food Science & Nutrition published by Wiley Periodicals LLC. in search of effective cancer treatments. Furthermore, the flavonoids in moringa seed can remove mitochondrial reactive oxygen specie

FAQs

What anticancer actions do moringa seed extracts show in the review?

They inhibit cancer cell proliferation and promote apoptosis through multiple signaling pathways, accompanied by increased intracellular ROS and caspase-3 activity.

Which caspases are mentioned as being stimulated by moringin and avenanthramide 2f?

The review states that moringin and avenanthramide 2f stimulate caspases 2, 4, 8, and 9, contributing to reduced cancer cell proliferation.

How does moringa seed oil relate to cardiovascular health in the article?

It is described as reducing cardiovascular disease risk by lowering malondialdehyde (MDA) formation and modulating cardiac superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity.

Sep 21, 2026

Uploaded by Eden