Advancements and recent explorations of anti-cancer activity of chrysin: from molecular targets to therapeutic perspective

Sep 21, 2026

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Recent advances clarify the anti-cancer potential of chrysin (CH), a naturally occurring flavonoid abundant in honey, propolis, and various fruits and vegetables. CH attracts attention for promising therapeutic activity with minimal toxicity. Its anti-cancer effects involve multi-target mechanisms, including apoptosis initiation and suppression of proliferation, angiogenesis, metastasis, and cell-cycle progression, alongside strong antioxidant and anti-inflammatory properties that reduce DNA-damage–linked carcinogenic processes. The review also highlights CH’s ability to sensitize tumors to chemotherapy and radiotherapy, improving efficacy while limiting harm to healthy cells. Current work consolidates CH composition, chemistry, mechanisms of action, safety concerns, and nanoformulation feasibility, positioning CH as a complementary anti-cancer option.

LanguageEnglish

CategoryHealthcare

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Reading Time45 min

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Exploration of Targeted Anti-tumor Therapy Open Access Review Advancements and recent explorations of anti-cancer activity of chrysin: from molecular targets to therapeutic perspective Abhilasha Sood1 , Arpit Mehrotra1 , Ujjawal Sharma2 , Diwakar Aggarwal3 , Tejveer Singh4 , Moyad Shahwan5,6 , Ammar Abdulrahman Jairoun7,8 , Isha Rani9 , Seema Ramniwas10 , Hardeep Singh Tuli3* , Vikas Yadav11* , Manoj Kumar12,13 1Department of Allied Health Sciences, Chitkara School of Health Sciences, Chitkara University, Rajpura 140401, India 2Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bhatinda 151001, India 3Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Ambala 133207, India 4Translational Oncology Laboratory, Department of Zoology, Hansraj College, Delhi University, New Delhi 110007, India 5Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman 346, United Arab Emirates 6Centre of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman 346, United Arab Emirates 7Health and Safety Department, Dubai Municipality, Dubai 67, United Arab Emirates 8Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM), Pulau Pinang 11500, Malaysia 9Department of Biochemistry, Maharishi Markandeshwar College of Medical Sciences and Research (MMCMSR), Sadopur, Ambala 134007, India 10University Centre for Research and Development, University Institute of Pharmaceutical Sciences, Chandigarh University, Gharuan, Mohali 140413, India 11Department of Translational Medicine, Clinical Research Centre, Skane University Hospital, Lund University, SE 20213 Malmö, Sweden 12Department of Chemistry, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Ambala 133207, India 13Department of Chemistry, Maharishi Markandeshwar University Sadopur, Ambala 134007, India *Correspondence: Hardeep Singh Tuli, Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Ambala 133207, [India.](India. hardeep.biotech@gmail.com)[ hardeep.biotech@gmail.com](India. hardeep.biotech@gmail.com); Vikas Yadav, Department of Translational Medicine, Clinical Research Centre, Skane University Hospital, Lund University, Jan Waldenströms Gata 35, SE 20213 Malmö, [Sweden.](Sweden. vikasyadav40@gmail.com)[ vikasyadav40@gmail.com](Sweden. vikasyadav40@gmail.com) [Academic Editor:](Academic Editor: Wei-Lin Jin)[ Wei-Lin Jin](Academic Editor: Wei-Lin Jin), [The First Clinical Medical College of Lanzhou University](The First Clinical Medical College of Lanzhou University), China Received: August 30, 2023 Accepted: November 28, 2023 Published: May 23, 2024 Cite this article: Sood A, Mehrotra A, Sharma U, Aggarwal D, Singh T, Shahwan M, et al. Advancements and recent explorations of anti-cancer activity of chrysin: from molecular targets to therapeutic perspective. Explor Target Antitumor Ther. 2024;5:477–94. [https://doi.org/10.37349/etat.2024.00230](https://doi.org/10.37349/etat.2024.00230) Abstract In recent times, there have been notable advancements in comprehending the potential anti-cancer effects of chrysin (CH), a naturally occurring flavonoid compound found abundantly in various plant sources like honey, propolis, and certain fruits and vegetables. This active compound has garnered significant attention due to its promising therapeutic qualities and minimal toxicity. CH’s ability to combat cancer arises from its multifaceted mechanisms of action, including the initiation of apoptosis and the inhibition of proliferation, angiogenesis, metastasis, and cell cycle progression. CH also displays potent antioxidant and anti- © The Author(s) 2024. This is an Open Access article licensed under a Creative Commons Att

FAQs

What is chrysin (CH) and why is it studied for cancer therapy?

Chrysin is a natural flavonoid found in sources such as honey, propolis, and some fruits and vegetables. It is studied because it shows anti-cancer activity with minimal toxicity and promising therapeutic potential.

How does chrysin exert anti-cancer effects?

Chrysin acts through multiple mechanisms, including initiating apoptosis and inhibiting proliferation, angiogenesis, metastasis, and cell-cycle progression, while also providing antioxidant and anti-inflammatory effects.

What does the review cover regarding clinical feasibility of chrysin?

It summarizes CH composition and chemistry, mechanisms of action, safety concerns, and the feasibility of nanoformulations, along with its potential to enhance traditional chemotherapy and radiotherapy.

Sep 21, 2026

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