A single-center study on epidemiology, microbial distribution, and mortality predictors in catheter-related bloodstream infections - Research Open Access

Q: What was the study objective regarding catheter-related bloodstream infections?

To investigate the epidemiology, microbial distribution, and predictors of 28-day mortality in CRBSI cases at a tertiary hospital from 2021 to 2023.

Q: How was the study conducted and which cases were analyzed?

A retrospective analysis included 142 confirmed CRBSI cases identified among 4297 blood culture specimens, analyzing demographics, clinical characteristics, pathogens, and outcomes.

Q: Which factors were independently associated with 28-day mortality in CRBSI patients?

Advanced age, ICU admission, altered consciousness, and low hemoglobin were independent predictors, and increased alkaline phosphatase, hemodialysis, and multidrug-resistant Gram-negative or fungal infections were also associated with higher mortality.

Sep 30, 2026

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Catheter-related bloodstream infections (CRBSIs) contribute substantially to mortality and healthcare costs. A retrospective single-center study investigated CRBSI epidemiology, microbial distribution, and factors predicting 28-day mortality among confirmed cases treated at a tertiary hospital from 2021 to 2023. Analysis included demographic and clinical characteristics, pathogen profiles, and patient outcomes. Logistic regression identified independent mortality predictors. Results showed declining CRBSI incidence, predominance of Gram-positive bacteria, and higher mortality linked to advanced age, ICU admission, altered consciousness, and low hemoglobin, along with elevated alkaline phosphatase, hemodialysis, and multidrug-resistant Gram-negative or fungal infections.

LanguageEnglish

CategoryResearch & Report

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Pages11

Reading Time28 min

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Abstract

Background

Methods

Results

Conclusions

Background

Clinical and epidemiological context

Knowledge gaps and study rationale

Li etal. BMC Infectious Diseases (2026) 26:17 BMC Infectious Diseases [https://doi.org/10.1186/s12879-025-12249-8](https://doi.org/10.1186/s12879-025-12249-8) RESEARCH Open Access A single-center study on epidemiology, microbial distribution, and mortality predictors in catheter-related bloodstream infections Shanfeng Li 1, Yu Xie 1, Weifen Liu 1, Yuying Wan 1, Jia Zuo2 and Hanjie Yi3* Abstract Background Catheter-related bloodstream infections (CRBSIs) are an important cause of mortality, and increased healthcare costs. The study aimed to investigate the epidemiology, microbial distribution, and predictors of 28-day mortality in CRBSI cases at a tertiary hospital from 2021 to 2023. Methods A retrospective analysis was conducted on 142 confirmed CRBSI cases identified among 4297 blood culture specimens. Demographic data, clinical characteristics, microbial pathogens, and patient outcomes were analyzed. Logistic regression was applied to determine independent predictors of 28-day mortality. Results From 2021 to 2023, a significant decline was observed in the incidence of CRBSIs (P < 0. 05) . The median patient age was 57.0 years, and the median interval from catheter insertion to CRBSI onset was 11.5 days. The 28-day mortality rate among patients with CRBSIs was 23 . 94% . Gram-positive bacteria were the predominant pathogens (53 .42%), with Staphylococcus aureus as the most common pathogen, followed by Gram-negative bacteria (25 . 34%) and fungi (21 . 23%) . Factors independently associated with mortality included advanced age, ICU admission, altered consciousness, and low hemoglobin levels. Furthermore, elevated alkaline phosphatase, hemodialysis, and infections caused by multidrug-resistant Gram-negative or fungi were also independently associated with increased mortality. Conclusions CRBSIs remain a serious healthcare challenge with a high mortality rate, particularly in older patients with comorbidities and prolonged ICU stays. Early identification of high-risk groups and targeted interventions are essential. Keywords Catheter-related bloodstream infection, Epidemiology, Microbial distribution, Mortality predictor *Correspondence: Hanjie Yi [ndefy20525@ncu.edu.cn](ndefy20525@ncu.edu.cn) 1Department of Nosocomial Infection Management, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China 2Information Office, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China 3Department of Oncology, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, Jiangxi 330000, China © The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/l](vecommons.org/l)icenses/by-nc-nd/4.0/. Li et al. BMC Infectious Diseases (2026) 26:17 Background Catheter-related bloodstream infection (CRBSI), accounting for 20%–30% of hospital-acquired infections, is commonly caused by central venous catheter (CVC) insertion [1]. It is a focal point in the efforts to prevent and control hospita

FAQs

What was the study objective regarding catheter-related bloodstream infections?

To investigate the epidemiology, microbial distribution, and predictors of 28-day mortality in CRBSI cases at a tertiary hospital from 2021 to 2023.

How was the study conducted and which cases were analyzed?

A retrospective analysis included 142 confirmed CRBSI cases identified among 4297 blood culture specimens, analyzing demographics, clinical characteristics, pathogens, and outcomes.

Which factors were independently associated with 28-day mortality in CRBSI patients?

Advanced age, ICU admission, altered consciousness, and low hemoglobin were independent predictors, and increased alkaline phosphatase, hemodialysis, and multidrug-resistant Gram-negative or fungal infections were also associated with higher mortality.

Sep 30, 2026

Upload by awa