A population-based study on incidence trends of kidney and renal pelvis cancers in the United States over 2000-2020

Sep 21, 2026

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Cancers of the kidney and renal pelvis are among the most prevalent urinary cancers. This study outlines incidence trends in the United States from 2000 to 2020 by age, sex, race/ethnicity, and histology using the SEER 22 database. Kidney and renal pelvis cancer cases were classified using ICD-O-3 morphologies. Estimates include counts and delayed age-standardized incidence rates per 100,000, with overall 490,481 cases recorded through 2019 and notable demographic and COVID-19 era changes in incidence.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages17

Reading Time43 min

AccessFree to download

Introduction

Study aims and data source (SEER 22)

Case identification and measures (ICD-O-3, AAPC, ASIR)

Background on kidney and renal pelvis cancer epidemiology

Prior US studies and research gaps

[www. nature.com/scientificreports](www. nature.com/scientificreports) OPEN A population‑based study on incidence trends of kidney and renal pelvis cancers in the United States over 2000–2020 Seyed Ehsan Mousavi1,2*, Morvarid Najafi3, Armin Aslani2, Asra Fazlollahi4, ZahraYekta5, Mohammad Sadri6 & Seyed Aria Nejadghaderi7,8* Cancers ofthe kidney and renal pelvis are among the most prevalent types of urinary cancers. We aimed to outline the incidence trends of kidney and renal pelvis cancers by age, sex, race/ ethnicity, and histology in the United States (US) from 2000 to 2020. The data was obtained from the Surveillance, Epidemiology, and End Results (SEER) 22 database. The identification of patients with kidney and renal pelvis cancers with morphologies of renal cell carcinoma, nephroblastoma, sarcoma, and neuroendocrine tumor was conducted utilizing the International Classification of Diseases for Oncology version 3. The average annual percent change (AAPC) were presented. All estimates were given in the form of counts and delayed age‑standardized incidence rates (ASIRs) per 100,000 people. From 2000 to 2019, a total of 490,481 cases of kidney and renal pelvic cancer were recorded across all age groups in the US. The majority of them were among Non‑Hispanic Whites (NHWs) (69.75%) and those aged 55–69 years (39.96%). TheASIRs per 100,000 for kidney and pelvis cancers were 22.03 for men and 11.14 for women. Non‑Hispanic Black men had the highest ASIR (24.53 [24.24, 24.81]), and increase inASIR over the 2000–2019 period (AAPC: 2.19%[1.84, 2.84]). There was a noticeable increase in incidence of kidney and renal pelvis cancers. Individuals aged 70–84 years had the highest ASIR for kidney and renal pelvis cancers. The COVID‑19 era has resulted in a significant reduction in incidence rates across all demographics. Keywords Kidney neoplasm, Renal pelvis, Epidemiology, United States, Surveillance, epidemiology, and end results, SEER, Incidence Kidney cancer develops from the cells composing the renal parenchyma, primarily those that line the renal tubules1. There are various morphological types of kidney cancer, with renal cell carcinoma (RCC) being the most common one2. Cancers ofthe renal pelvis develop mostly in the transitional epithelium, and are classified as either urothelial or non-urothelial carcinomas3. In 2020, kidney cancer globally ranked 14th and 15th in terms of prevalence and death among all types of cancers, respectively4. By sex, kidney cancer ranked as the 9th most prevalent cancer in men and the 14th most prevalent one in females4. In 2020, a total of 431,288 new cases and 179,368 deaths attributed to kidney cancer were reported worldwide, with substantial variation in geographical distribution4. The incidence of kidney cancer 1Neurosciences Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran. 2Department of Community Medicine, Faculty of Medicine, Social Determinants of Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 3School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 4Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. 5Calaveras County Department of Health, Calaveras County, CA, USA. 6Assistant Professor of Urology, Nephrology and Kidney Transplant Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran. 7HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran. 8Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran. *email: mousavi.e@ [tbzmed.ac.ir](tbzmed.ac.ir); [drehsanmousavii@gmail.com](drehsanmousavii@gmail.com); [ariaghaderi@sbmu.ac.ir](ariaghaderi@sbmu.ac.ir); [ariang20@gmail.com](ariang20@gmail.com) [www. nature.com/scienti

FAQs

What was the purpose of the population-based study?

To outline incidence trends of kidney and renal pelvis cancers in the United States from 2000 to 2020 by age, sex, race/ethnicity, and histology.

Which database and classification system were used?

The data came from the Surveillance, Epidemiology, and End Results (SEER) 22 database, and case morphologies were identified using the International Classification of Diseases for Oncology, version 3 (ICD-O-3).

How were incidence trends quantified in the study?

Incidence was reported as counts and delayed age-standardized incidence rates (ASIRs) per 100,000, along with average annual percent change (AAPC) to summarize trend direction and magnitude.

Sep 21, 2026

Uploaded by Aurora