A new tumor-treating device OM-100 with low-frequency magnetic fields inhibits proliferation and metastasis in liver cancer

Q: What is the purpose of OM-100 in this study?

To investigate whether the novel OM-100 device delivering low-frequency magnetic fields can be applied to treat liver cancer by evaluating anti-cancer effects and safety.

Q: How were cells treated to test OM-100 effects?

Liver cancer cell lines HepG2 and Huh7 and a normal liver cell line THLE-2 were exposed to OM-100 at 0, 10, 25, 50, and 100 kHz for 2 hours in the morning, noon, and evening.

Q: What outcomes did OM-100 produce in liver cancer models?

In vitro, OM-100 reduced cancer cell viability, increased apoptosis, and inhibited migration and invasion in a frequency-dependent manner; in vivo, it slowed tumor growth and promoted apoptosis while rarely harming normal cells or mice.

Sep 21, 2026

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Background: This study evaluates a novel instrument, OM-100, using low-frequency magnetic fields (LFMFs), to assess its potential for treating liver cancer. Methods: HepG2 and Huh7 liver cancer cells and THLE-2 normal liver cells were exposed to OM-100 at 0, 10, 25, 50, and 100 kHz for 2 hours across morning, noon, and evening, assessing viability, apoptosis, migration, invasion, and ROS. In vivo experiments examined safety and tumor growth. Results: OM-100 reduced cancer cell viability, induced apoptosis, and suppressed migration and invasion in a frequency-dependent manner, with tumor growth slowing in vivo; ROS increased and supported autophagy-related progression. Conclusion: OM-100 showed safety and strong inhibition of liver cancer progression at 100 kHz.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages12

Reading Time30 min

AccessFree to download

Background

Methods

In vitro exposure

In vivo safety and tumor growth

Results

Conclusion

Keywords

Zhang et al. BMC Cancer (2024) 24:1383 BMC Cancer [https://doi.org/10.1186/s12885-024-13121-9](https://doi.org/10.1186/s12885-024-13121-9) RESEARCH Open Access A new tumor-treating device OM-100 with low-frequency magnetic fields inhibits proliferation and metastasis in liver cancer Xin Zhang 1, Zhaoxian Yan2, Lifa Huang 1, Xinyan Yu3 and Rui Huang3* Abstract Background This study aims to investigate a novel instrument OM-100 with low-frequency magnetic fields (LFMFs) for its potential applicability in the treatment of liver cancer. Methods Liver cancer cell lines (HepG2 and Huh7) and normal liver cell line THLE-2 were exposed to OM-100 at LFMFs of 0, 10, 25, 50, and 100 kHz for 2 h in the morning, noon, and evening, respectively. The effects of LFMF on cell viability, apoptosis, migration, and invasion capabilities were examined. Additionally, impacts of LFMF on ROS production was assessed. In vivo studies were conducted to examine the safety profile of OM-100 and its effects on tumor growth. Results In vitro, OM-100 reduced the viability of liver cancer cells, increased cell apoptosis, and inhibited cell migration and invasion abilities in a frequency-dependent manner (P < 0. 05) . In vivo, OM-100 significantly slowed down tumor growth and promoted apoptosis in liver tumors (P < 0. 05) . Moreover, OM-100 rarely affected the viability of normal liver cells, as well as the health of normal mice. Finally, we further found that OM-100 significantly increased the production of ROS in liver cancer cells (P < 0. 05), a key factor in inducing autophagy, which is very important for the progression of liver cancer. Conclusion Our findings reveal the safety of OM-100 and its frequency at 100 kHz significantly inhibits liver cancer progression. Keywords Tumor treating instrument, Low-frequency magnetic fields, Liver cancer, Proliferation, Migration, Invasion, Xenograft tumor model *Correspondence: Rui Huang [13757190179@163.com](13757190179@163.com) 1Department of Neurosurgery, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China 2Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 3Department of Medical, Ci Xing Technology Co., Ltd, No. 100, Changhe Road, Hangzhou 310051, China © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/l](vecommons.org/l)icenses/by-nc-nd/4.0/. Zhang et al. BMC Cancer (2024) 24:1383 Background Liver cancer, a prevalent health dilemma worldwide, is a significant global health issue [1]. Occupying the third position in terms of fatal outcomes, it is responsible for approximately 8.3% of all worldwide cancer deaths and emerges as the principal cause of cancer-related mortality among men globally [2]. Even with advancements in diagnosis and various treatment modalities—ranging from surgical intervention and liver transplants to chemotherapeutic and targeted appr

FAQs

What is the purpose of OM-100 in this study?

To investigate whether the novel OM-100 device delivering low-frequency magnetic fields can be applied to treat liver cancer by evaluating anti-cancer effects and safety.

How were cells treated to test OM-100 effects?

Liver cancer cell lines HepG2 and Huh7 and a normal liver cell line THLE-2 were exposed to OM-100 at 0, 10, 25, 50, and 100 kHz for 2 hours in the morning, noon, and evening.

What outcomes did OM-100 produce in liver cancer models?

In vitro, OM-100 reduced cancer cell viability, increased apoptosis, and inhibited migration and invasion in a frequency-dependent manner; in vivo, it slowed tumor growth and promoted apoptosis while rarely harming normal cells or mice.

Sep 21, 2026

Upload by Skyler