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The program illustrates diverse numerical interactions among up to four datasets and provides flexible exports, allowing grouped data points in selected regions to be saved into spreadsheets. It supports straightforward evaluation of two to four gene sets with corresponding expression values in a user-friendly workflow. Application to differential oxygen tension effects on primary rat astrocytes demonstrates accurate group separation and efficient visualization for analysis and data output. The approach improves interpretability and supports downstream work in genomics, proteomics, and bioinformatics.",{"@graph":63,"@context":119},[64,80,102],{"@type":65,"itemListElement":66},"BreadcrumbList",[67,71,74,77],{"item":68,"name":69,"@type":70,"position":9},"https://docshare.wps.com","Home","ListItem",{"item":72,"name":10,"@type":70,"position":73},"https://docshare.wps.com/template/",2,{"item":75,"name":51,"@type":70,"position":76},"https://docshare.wps.com/template/general/",3,{"item":78,"name":59,"@type":70,"position":79},"https://docshare.wps.com/template/vennplex-a-novel-venn-diagram-program-for-comparing-and-visualizing-differentially-regulated-datapoints/189814/",4,{"url":78,"name":59,"@type":81,"image":82,"author":87,"headline":59,"publisher":90,"fileFormat":93,"inLanguage":57,"description":61,"dateModified":94,"datePublished":95,"encodingFormat":93,"isAccessibleForFree":96,"interactionStatistic":97},"DigitalDocument",{"url":83,"@type":84,"width":85,"height":86},"https://docshare.wps.com/thumbnails/vennplex-a-novel-venn-diagram-program-for-comparing-and-visualizing-differentially-regulated-datapoints/189814.png","ImageObject",442,249,{"name":88,"@type":89},"\tCallum ","Person",{"url":68,"name":91,"@type":92},"DocShare","Organization","application/pdf","2026-09-26","2026-09-03",true,{"@type":98,"interactionType":99,"userInteractionCount":101},"InteractionCounter",{"@type":100},"ViewAction",7,{"@type":103,"mainEntity":104},"FAQPage",[105,111,115],{"name":106,"@type":107,"acceptedAnswer":108},"What problem does VennPlex address in Venn diagram analysis?","Question",{"text":109,"@type":110},"VennPlex targets the inability of many free Venn diagram tools to represent additional complexity among datasets, including differential interactions across groups.","Answer",{"name":112,"@type":107,"acceptedAnswer":113},"How many datasets can VennPlex analyze and visualize?",{"text":114,"@type":110},"VennPlex supports up to four datasets, enabling analysis of two to four gene sets alongside corresponding expression values.",{"name":116,"@type":107,"acceptedAnswer":117},"What outputs does VennPlex provide for downstream analysis?",{"text":118,"@type":110},"Grouped data points in specific regions can be exported into a spreadsheet, facilitating straightforward analysis and data output.","https://schema.org",{"og:url":78,"og:type":121,"og:title":59,"og:site_name":91,"og:description":61},"article",{"robots":123,"canonical":78},"index,follow",{"doc_id":125,"site_id":56},189814,1788399415,{"code":4,"msg":5,"data":128},{"doc_id":125,"user_id":129,"nickname":88,"user_avatar":130,"doc_module":9,"category_id":50,"category_name":51,"doc_title":59,"doc_description":61,"doc_content":131,"file_id":132,"file_url":133,"file_type":134,"file_size":135,"view_count":101,"is_deleted":4,"is_public":9,"is_downloadable":9,"audit_status":9,"page_count":136,"language":137,"language_code":57,"site_id":56,"html_lang":57,"table_of_contents":138,"faqs":139,"seo_title":140,"seo_description":61,"update_tm":126,"read_time":73},137451211410,"https://ap-avatar.wpscdn.com/avatar/2000bb0a9246f588df?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786362646172706240","| Abstract\u003Cbr>With the development of increasingly large and complex genomic and proteomic data sets, an enhancement in the complexity of available Venn diagram analytical programs is becoming increasingly important. Current freely available Venn diagram programs often fail to represent extra complexity among datasets, such as regulation pattern differences between different groups. Here we describe the development of VennPlex, a program that illustrates the often diverse numerical interactions among multiple, high-complexity datasets, using up to four data sets. VennPlex includes versatile output features, where grouped data points in specific regions can be easily exported into a spreadsheet. This program is able to facilitate the analysis of two to four gene sets and their corresponding expression values in a user-friendly manner. To demonstrate its unique experimental utility we applied VennPlex to a complex paradigm, i.e. a comparison of the effect of multiple oxygen tension environments (1–20% ambient oxygen) upon gene transcription of primary rat astrocytes. VennPlex accurately dissects complex data sets reliably into easily identifiable groups for straightforward analysis and data output. This program, which is an improvement over currently available Venn diagram programs, is able to rapidly extract important datasets that represent the variety of expression patterns available within the data sets, showing potential applications in fields like genomics, proteomics, and bioinformatics. |\n| --- |\n| Citation: Cai H, Chen H, Yi T, Daimon CM, Boyle JP, et al. (2013) VennPlex–A Novel Venn Diagram Program for Comparing and Visualizing Datasets with\u003Cbr>Differentially Regulated Datapoints. PLoS ONE 8(1): e53388 . doi:10.1371/journal.pone.0053388\u003Cbr>Editor: Niall James Haslam, University College Dublin, Ireland\u003Cbr>Received September 7, 2012; Accepted November 27, 2012; Published January 7, 2013\u003Cbr>This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.\u003Cbr>Funding: This work was supported by the Intramural Research Program of the National Institute on Aging, National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.\u003Cbr>Competing Interests: The authors have declared that no competing interests exist.\u003Cbr>* [E-mail: martinbro@mail.nih.gov](E-mail: martinbro@mail.nih.gov)\u003Cbr>. These authors contributed equally to this work. |","cbCaiuFFuo14E8Qc","https://ap.wps.com/l/cbCaiuFFuo14E8Qc","pdf",1700050,6,"English","# Abstract\n# Citation and publication details","[{\"question\":\"What problem does VennPlex address in Venn diagram analysis?\",\"answer\":\"VennPlex targets the inability of many free Venn diagram tools to represent additional complexity among datasets, including differential interactions across groups.\"},{\"question\":\"How many datasets can VennPlex analyze and visualize?\",\"answer\":\"VennPlex supports up to four datasets, enabling analysis of two to four gene sets alongside corresponding expression values.\"},{\"question\":\"What outputs does VennPlex provide for downstream analysis?\",\"answer\":\"Grouped data points in specific regions can be exported into a spreadsheet, facilitating straightforward analysis and data output.\"}]","VennPlex - A Novel Venn Diagram Program for Comparing and Visualizing Differentially Regulated Datapoints | PDF"]