[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-1-en-105":3,"doc-seo-197255-105":53,"doc-detail-197255-en":126},{"code":4,"msg":5,"data":6},0,"success",[7,14,19,24,29,34,39,44,49],{"id":8,"doc_module":9,"doc_module_name":10,"category_name":11,"show_sort_weight":12,"slug":13},11,1,"Template","Presentations",90,"presentations",{"id":15,"doc_module":9,"doc_module_name":10,"category_name":16,"show_sort_weight":17,"slug":18},12,"Resumes",80,"resumes",{"id":20,"doc_module":9,"doc_module_name":10,"category_name":21,"show_sort_weight":22,"slug":23},14,"Invoices",70,"invoices",{"id":25,"doc_module":9,"doc_module_name":10,"category_name":26,"show_sort_weight":27,"slug":28},15,"Posters",60,"posters",{"id":30,"doc_module":9,"doc_module_name":10,"category_name":31,"show_sort_weight":32,"slug":33},16,"Social Media",50,"social-media",{"id":35,"doc_module":9,"doc_module_name":10,"category_name":36,"show_sort_weight":37,"slug":38},17,"Forms",40,"forms",{"id":40,"doc_module":9,"doc_module_name":10,"category_name":41,"show_sort_weight":42,"slug":43},18,"Letters",30,"letters",{"id":45,"doc_module":9,"doc_module_name":10,"category_name":46,"show_sort_weight":47,"slug":48},21,"Paper Templates",5,"papers-templates",{"id":50,"doc_module":9,"doc_module_name":10,"category_name":51,"show_sort_weight":4,"slug":52},158,"General","general-158",{"code":4,"msg":54,"data":55},"ok",{"site_id":56,"language":57,"slug":58,"title":59,"keywords":60,"description":61,"schema_data":62,"social_meta":119,"head_meta":121,"extra_data":123,"updated_unix":125},105,"en","supplementary-appendix-72118-1-10-20200825","Supplementary Appendix 72118-1-10 20200825","","Hazard ratio analysis with 95% confidence intervals evaluates survival outcomes by patient subgroup characteristics. Sex, age, ISS stage, specific genetic alterations, early relapse status, maintenance therapy, and best treatment response are compared using p-values for statistical significance. Results highlight that older age (≥60y), higher ISS categories, presence of del(17p) and/or t(4;14), and early relapse (≤18 months) are associated with increased hazard, while maintenance shows no statistically significant difference. Treatment regimen comparisons also report significant effects in doublet versus triplet groups.",{"@graph":63,"@context":118},[64,80,101],{"@type":65,"itemListElement":66},"BreadcrumbList",[67,71,74,77],{"item":68,"name":69,"@type":70,"position":9},"https://docshare.wps.com","Home","ListItem",{"item":72,"name":10,"@type":70,"position":73},"https://docshare.wps.com/template/",2,{"item":75,"name":51,"@type":70,"position":76},"https://docshare.wps.com/template/general/",3,{"item":78,"name":59,"@type":70,"position":79},"https://docshare.wps.com/template/supplementary-appendix-72118-1-10-20200825/197255/",4,{"url":78,"name":59,"@type":81,"image":82,"author":87,"headline":59,"publisher":90,"fileFormat":93,"inLanguage":57,"description":61,"dateModified":94,"datePublished":95,"encodingFormat":93,"isAccessibleForFree":96,"interactionStatistic":97},"DigitalDocument",{"url":83,"@type":84,"width":85,"height":86},"https://docshare.wps.com/thumbnails/supplementary-appendix-72118-1-10-20200825/197255.png","ImageObject",442,249,{"name":88,"@type":89},"Gloria","Person",{"url":68,"name":91,"@type":92},"DocShare","Organization","application/pdf","2026-09-20","2026-09-03",true,{"@type":98,"interactionType":99,"userInteractionCount":73},"InteractionCounter",{"@type":100},"ViewAction",{"@type":102,"mainEntity":103},"FAQPage",[104,110,114],{"name":105,"@type":106,"acceptedAnswer":107},"Which patient subgroup variables are evaluated using hazard ratios?","Question",{"text":108,"@type":109},"The analysis evaluates sex, age categories, ISS stage, del(17p) and/or t(4;14), early relapse status (≤18 months), maintenance, best response, and treatment regimen (triplet vs doublet).","Answer",{"name":111,"@type":106,"acceptedAnswer":112},"What subgroup factors show significant association with increased hazard?",{"text":113,"@type":109},"Older age (≥60y), higher ISS categories, presence of del(17p) and/or t(4;14), and early relapse (≤18 months) show increased hazard with statistically significant p-values.",{"name":115,"@type":106,"acceptedAnswer":116},"Is maintenance therapy associated with a statistically significant hazard difference?",{"text":117,"@type":109},"No. The maintenance comparison reports p = 0.2298, indicating no statistically significant difference between groups in the provided results.","https://schema.org",{"og:url":78,"og:type":120,"og:title":59,"og:site_name":91,"og:description":61},"article",{"robots":122,"canonical":78},"index,follow",{"doc_id":124,"site_id":56},197255,1788466134,{"code":4,"msg":5,"data":127},{"doc_id":124,"user_id":128,"nickname":88,"user_avatar":129,"doc_module":9,"category_id":50,"category_name":51,"doc_title":59,"doc_description":61,"doc_content":130,"file_id":131,"file_url":132,"file_type":133,"file_size":134,"view_count":73,"is_deleted":4,"is_public":9,"is_downloadable":9,"audit_status":9,"page_count":135,"language":136,"language_code":57,"site_id":56,"html_lang":57,"table_of_contents":60,"faqs":137,"seo_title":138,"seo_description":61,"update_tm":125,"read_time":73},2336474459895,"https://ap-avatar.wpscdn.com/avatar/22000baeef7a5ed0655?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786071322749376916","| Death / N | Hazard Ratio [IC95%] |  |\n| --- | --- | --- |\n| Sex : |  | p = 0.0976 |\n| Male 309 / 1396 | 1.00 |  |\n| Female 207 / 1025 | 0.86 [ 0. 72; 1.03] |  |\n| Age : |  | p = 0.0055 |\n| \u003C60y 284 / 1405 | 1.00 |  |\n| >=60y 235 / 1069 | 1.28 [ 1.07; 1.52] |  |\n| ISS : |  | p \u003C 0.0001 |\n| 1 91 / 690 | 1.00 |  |\n| 2 194 / 882 | 1.76 [ 1.37; 2.26] |  |\n| 3 153 / 481 | 2.39 [ 1.84; 3.09] |  |\n| Del 17p and/or t4;14) : |  | p \u003C 0.0001 |\n| No 319 / 1782 | 1.00 |  |\n| Yes 141 / 359 | 2.63 [ 2 . 16; 3.21] |  |\n| Early relapse (\u003C18 months) : |  | p \u003C 0.0001 |\n| No 327 / 2131 | 1.00 |  |\n| Yes 192 / 343 | 5.96 [ 4 .98; 7. 14] |  |\n| Maintenance : |  | p = 0.2298 |\n| No 467 / 2179 | 1.00 |  |\n| Yes 52 / 295 | 0.84 [ 0.63; 1. 12] |  |\n| Best response: |  | p = 0.0036 |\n| VGPR/CR 222 / 1224 | 1.00 |  |\n| SD/RP 94 / 299 | 1.43 [ 1. 12; 1.82] |  |\n| Treatment : |  | p = 0.0002 |\n| Triplet 198 / 1552 | 1.00 |  |\n| Doublet 321 / 922 | 1.41 [ 1. 17; 1.69] |  |\n\n\n| (n=1178, 255 events) Hazard Ratio IC95% | p value |\n| --- | --- |\n| ISS |  |\n| 1 1.00 |  |\n| 2 1.72 [1 .24; 2.38] | 0.0012 |\n| 3 1.89 [1 .33; 2.68] | 0.0003 |\n| Early relapse (\u003C18 months)\u003Cbr>No 1.00 |  |\n| Yes 4.40 [3 .34; 5.81] | \u003C0.0001 |\n| del17p &/ or t(4;14) |  |\n| No 1.00 |  |\n| Yes 2.05 [1 .54; 2.72] | \u003C0.0001 |\n| Best response |  |\n| VGPR/CR 1.00 |  |\n| SD/RP 1.15 [0 .86; 1.54] | 0.3470 |\n| Treatment |  |\n| Triplet 1.00 |  |\n| Doublet 1.54 [ 1. 18; 2.00] | 0.0015 |\n\n\n| No relapse within 18m N = 2131 |  |  | Early relapse (≤18m) N = 496 | p value |\n| --- | --- | --- | --- | --- |\n| Del(17p) and/or t(4;14) (n = 2273) |  |  | 300 (67 .4%)\u003Cbr>145 (32 .6%) 51\u003Cbr>141 (69 .8%)\u003Cbr>61 (30 .2%) 294\u003Cbr>99 (48 . 1%)\u003Cbr>107 (51 .9%) 290\u003Cbr>167 (81 .9%)\u003Cbr>37 (18 . 1%) 292\u003Cbr>57 (20 .9%)\u003Cbr>216 (79 . 1%) 223 | p \u003C 0.0001\u003Cbr>p = 0.0024\u003Cbr>p \u003C 0.0001\u003Cbr>p = 0.0007\u003Cbr>p \u003C 0.0001 |\n| No Yes Missing\u003Cbr>Trisomy 5 (n = 830) No\u003Cbr>Yes Missing\u003Cbr>Gain 1q (n = 840) No\u003Cbr>Yes Missing\u003Cbr>Del(1p32) (n = 820) No\u003Cbr>Yes Missing |  | 1560 (85 .3%)\u003Cbr>268 (14 .7%) 303\u003Cbr>363 (57 .8%) 265 (42 .2%) 1503\u003Cbr>420 (66 .2%) 214 (33 .8%) 1497\u003Cbr>558 (90 .6%) 58 (9 .4%)\u003Cbr>1515 |  |  |\n| Del(17p) or t(4;14) or gain 1q or del(1p32) (n = 1061) |  |  |  |  |\n| No Yes Missing | 330 (41 .9%)\u003Cbr>458 (58 . 1%) 1343 |  |  |  |","cbCaiesPQHnWSLwS","https://ap.wps.com/l/cbCaiesPQHnWSLwS","pdf",399138,6,"English","[{\"question\":\"Which patient subgroup variables are evaluated using hazard ratios?\",\"answer\":\"The analysis evaluates sex, age categories, ISS stage, del(17p) and/or t(4;14), early relapse status (≤18 months), maintenance, best response, and treatment regimen (triplet vs doublet).\"},{\"question\":\"What subgroup factors show significant association with increased hazard?\",\"answer\":\"Older age (≥60y), higher ISS categories, presence of del(17p) and/or t(4;14), and early relapse (≤18 months) show increased hazard with statistically significant p-values.\"},{\"question\":\"Is maintenance therapy associated with a statistically significant hazard difference?\",\"answer\":\"No. The maintenance comparison reports p = 0.2298, indicating no statistically significant difference between groups in the provided results.\"}]","Supplementary Appendix 72118-1-10 20200825 | PDF"]