[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-1-en-105":3,"doc-seo-219213-105":53,"doc-detail-219213-en":126},{"code":4,"msg":5,"data":6},0,"success",[7,14,19,24,29,34,39,44,49],{"id":8,"doc_module":9,"doc_module_name":10,"category_name":11,"show_sort_weight":12,"slug":13},11,1,"Template","Presentations",90,"presentations",{"id":15,"doc_module":9,"doc_module_name":10,"category_name":16,"show_sort_weight":17,"slug":18},12,"Resumes",80,"resumes",{"id":20,"doc_module":9,"doc_module_name":10,"category_name":21,"show_sort_weight":22,"slug":23},14,"Invoices",70,"invoices",{"id":25,"doc_module":9,"doc_module_name":10,"category_name":26,"show_sort_weight":27,"slug":28},15,"Posters",60,"posters",{"id":30,"doc_module":9,"doc_module_name":10,"category_name":31,"show_sort_weight":32,"slug":33},16,"Social Media",50,"social-media",{"id":35,"doc_module":9,"doc_module_name":10,"category_name":36,"show_sort_weight":37,"slug":38},17,"Forms",40,"forms",{"id":40,"doc_module":9,"doc_module_name":10,"category_name":41,"show_sort_weight":42,"slug":43},18,"Letters",30,"letters",{"id":45,"doc_module":9,"doc_module_name":10,"category_name":46,"show_sort_weight":47,"slug":48},21,"Paper Templates",5,"papers-templates",{"id":50,"doc_module":9,"doc_module_name":10,"category_name":51,"show_sort_weight":4,"slug":52},158,"General","general-158",{"code":4,"msg":54,"data":55},"ok",{"site_id":56,"language":57,"slug":58,"title":59,"keywords":60,"description":61,"schema_data":62,"social_meta":119,"head_meta":121,"extra_data":123,"updated_unix":125},105,"en","supplemental-tables-figures-and-exploratory-analyses-supplemental-material-english-language","Supplemental tables, figures, and exploratory analyses - Supplemental material - English language","","Supplemental material for a large-scale population study examines early-life factors associated with left-handedness. The document provides univariable and multivariable analyses of handedness in male and female participants, including effects of multiple birth status, maternal smoking, breastfeeding, and country of origin, alongside continuous predictors such as year of birth, year squared, birthweight, and month-related measures. Additional heritability and genetic-correlation results are summarized in supplemental tables and figures, with further exploratory analyses addressing seasonal modeling and outcomes related to low birthweight and multiple births.",{"@graph":63,"@context":118},[64,80,101],{"@type":65,"itemListElement":66},"BreadcrumbList",[67,71,74,77],{"item":68,"name":69,"@type":70,"position":9},"https://docshare.wps.com","Home","ListItem",{"item":72,"name":10,"@type":70,"position":73},"https://docshare.wps.com/template/",2,{"item":75,"name":51,"@type":70,"position":76},"https://docshare.wps.com/template/general/",3,{"item":78,"name":59,"@type":70,"position":79},"https://docshare.wps.com/template/supplemental-tables-figures-and-exploratory-analyses-supplemental-material-english-language/219213/",4,{"url":78,"name":59,"@type":81,"image":82,"author":87,"headline":59,"publisher":90,"fileFormat":93,"inLanguage":57,"description":61,"dateModified":94,"datePublished":95,"encodingFormat":93,"isAccessibleForFree":96,"interactionStatistic":97},"DigitalDocument",{"url":83,"@type":84,"width":85,"height":86},"https://docshare.wps.com/thumbnails/supplemental-tables-figures-and-exploratory-analyses-supplemental-material-english-language/219213.png","ImageObject",442,249,{"name":88,"@type":89},"Chloe Bennett","Person",{"url":68,"name":91,"@type":92},"DocShare","Organization","application/vnd.openxmlformats-officedocument.wordprocessingml.document","2026-09-22","2026-09-08",true,{"@type":98,"interactionType":99,"userInteractionCount":79},"InteractionCounter",{"@type":100},"ViewAction",{"@type":102,"mainEntity":103},"FAQPage",[104,110,114],{"name":105,"@type":106,"acceptedAnswer":107},"Which early-life variables are evaluated for handedness in the supplemental tables?","Question",{"text":108,"@type":109},"The supplemental tables assess multiple birth status, maternal smoking, breastfeeding, and country of origin, plus continuous predictors including year of birth, birthweight, and month-related measures.","Answer",{"name":111,"@type":106,"acceptedAnswer":112},"What do the multivariable models estimate for handedness?",{"text":113,"@type":109},"The multivariable logistic models estimate odds ratios for being right-handed (with 95% confidence intervals) in male and female participants while adjusting for multiple predictors.",{"name":115,"@type":106,"acceptedAnswer":116},"What additional analyses are included beyond the main models?",{"text":117,"@type":109},"The document includes exploratory analyses such as additional models for season and additional analysis related to low birthweight and multiple births.","https://schema.org",{"og:url":78,"og:type":120,"og:title":59,"og:site_name":91,"og:description":61},"article",{"robots":122,"canonical":78},"index,follow",{"doc_id":124,"site_id":56},219213,1788862620,{"code":4,"msg":5,"data":127},{"doc_id":124,"user_id":128,"nickname":88,"user_avatar":129,"doc_module":9,"category_id":50,"category_name":51,"doc_title":59,"doc_description":61,"doc_content":130,"file_id":131,"file_url":132,"file_type":133,"file_size":134,"view_count":76,"is_deleted":4,"is_public":9,"is_downloadable":9,"audit_status":9,"page_count":30,"language":135,"language_code":57,"site_id":56,"html_lang":57,"table_of_contents":136,"faqs":137,"seo_title":138,"seo_description":61,"update_tm":125,"read_time":139},962084925782,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","A large-scale population study of early life factors influencing left-handedness\nCarolien G.F. de Kovela, Amaia Carrión-Castilloa, Clyde Francksa,b,*\na Department of Language and Genetics, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands\nb Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands\nSupplementary information\n\u000f\nSupplemental tables, figures, and exploratory analyses\nSupplemental Tables\nSupp. Table 1. Univariable analysis of early life variables and handedness, male participants\nSupp. Table 2. Univariable analysis of early life variables and handedness, female participants\nSupp. Table 3 Multivariable model for right-handedness, male participants\nSupp. Table 4 Multivariable model for right-handedness, female participants\nSupp. Table 5. Heritability estimates of handedness and covariates of interest\nSupp. Table 6. Genetic correlation of handedness with a second trait\nSupplemental Figures\nSupp. Figure 1 Male and female participants by year of birth\nSupp. Figure 2 Left-handedness vs year of birth\nSupp. Figure 3 Left-handedness vs birthweight\nSupp. Figure 4 Left-handedness vs month of birth\nSupp. Figure 5 Birthweight vs year of birth\nSupp. Figure 6 Birthweight vs month of birth\nSupp. Figure 7. Power analysis for genetic correlation\nSupp. Figure 8. Genetic correlations between variables\nSupplemental Analyses\nAdditional models for season\nAdditional analysis of low birthweight and multiple birth\nTables\nSupp. Table S\u0013 SEQ Supp._Table \\* ARABIC \u00141\u0015. Univariable analysis of categorical variables for handedness in males only\nMALES\u000bCategorical\nN\np-value\nFrequency of left-handedness\nNotes\nOR right-handed (95% C.I.)\npart of multiple birth\n189,180\n0.007\nnon-twin = 10.6%, twin=11.9%\n2.2% of participants are from multiple birth\n0.88 (0.80-0.96)\nmaternal smoking\n164,876\n0.096\nnon-smoking=10.5%; smoking=10.8%\n30% of mothers smoked around pregnancy\n0.97 (0.94-1.01)\nbreastfeeding\n151,613\n6.3E-23\nbreastfed=10.2%, not breastfed=12.0%\n76% of participants were breastfed\n1.20 (1.16-1.25)\ncountry of origin\n215,422\n5.1E-58\nLowest frequency non-right-handers born outside UK, highest in England\nEngland\n148,688\n11.3%\nNorthern Ireland\n1,341\n10.1%\n1.13 (0.95-1.36)\nScotland\n15,532\n9.3%\n1.23 (1.16-1.30)\nWales\n8,446\n8.7%\n1.34 (1.24-1.45)\nRepublic of Ireland\n2,032\n8.2%\n1.42 (1.21-1.66)\nElsewhere\n16,161\n7.7%\n1.51 (1.42-1.60)\nMALES\u000bContinuous\nN\np-value\nNote\nEffect size on right-handed\nyear of birth\n192,569\n6.5E-14\nIncrease left-handers ~ 0.7 percentage-point per decade\nEffect = -0.007 yr-1\nyear squared\n0.058\nbirthweight\n89,924\n0.001\nLeft-handers are ~24g lighter on average\nEffect = 0.052 kg-1\ncosine(month)\n192,569\n0.388\nSee Figure S4\nEffect = 0.006\n\u000f\nSupp. Table S\u0013 SEQ Supp._Table \\* ARABIC \u00142\u0015. Univariable analysis for handedness in females only\nFEMALES\u000bCategorical\nN\np-value\nFrequency of left-handedness\nNotes\nOR right-handed (95% C.I.)\npart of multiple birth\n225,380\n5.9E-07\nnon-twin = 8.5%, twin=10.5%\n2.3% of participants are from multiple birth\n0.79 (0.72-0.87)\nmaternal smoking\n198,990\n0.914\nnon-smoking=8.5%; smoking=8.6%\n30% of mothers smoked around pregnancy\n1.0 (0.96-1.03)\nbreastfeeding\n185,231\n1.1E-13\nbreastfed=8.3%, not breastfed=9.3%\n70% of participants were breastfed\n1.14 (1.10-1.18)\ncountry of origin\n228,739\n8.7E-88\nLowest frequency non-right-handers born outside UK, highest in England\nEngland\n196,351\n9.3%\nNorthern Ireland\n1,558\n7.8%\n1.21 (1.01-1.47)\nScotland\n18,892\n7.1%\n1.33 (1.26-1.41)\nWales\n9,924\n6.3%\n1.52 (1.39-1.65)\nRepublic of Ireland\n2,769\n6.6%\n1.44 (1.24-1.69)\nElsewhere\n21,997\n6.0%\n1.59 (1.50-1.69)\nFEMALES, continuous\nN\np-value\nNote\nEffect size on right-handed\nyear of birth\n229,098\n7.3E-23\nIncrease left-handed ~ 0.8 percentage-point per decade\nEffect = -0.009 yr-1\nyear squared\n0.014\n-\n-\nbirthweight\n141,231\n3.1E-06\nLeft-handers are ~28g lighter on average\nEffect = 0.068 kg-1\ncosine(month)\n255,401\n0.0012\nSee Figure S4\nEffect = 0.034\n\u000f\nSupp. Table S\u0013 SEQ Supp._Table \\* ","cbCaikuUNFErpcqg","https://ap.wps.com/l/cbCaikuUNFErpcqg","docx",805953,"English","# Supplemental Tables\n## Univariable analyses (males)\n## Univariable analyses (females)\n## Multivariable logistic models (males)\n## Multivariable logistic models (females)\n## Heritability estimates\n# Supplemental Figures\n## Participant patterns by birth year\n## Left-handedness associations with birth variables\n## Power and genetic correlations\n# Supplemental Analyses","[{\"question\":\"Which early-life variables are evaluated for handedness in the supplemental tables?\",\"answer\":\"The supplemental tables assess multiple birth status, maternal smoking, breastfeeding, and country of origin, plus continuous predictors including year of birth, birthweight, and month-related measures.\"},{\"question\":\"What do the multivariable models estimate for handedness?\",\"answer\":\"The multivariable logistic models estimate odds ratios for being right-handed (with 95% confidence intervals) in male and female participants while adjusting for multiple predictors.\"},{\"question\":\"What additional analyses are included beyond the main models?\",\"answer\":\"The document includes exploratory analyses such as additional models for season and additional analysis related to low birthweight and multiple births.\"}]","Supplemental tables, figures, and exploratory analyses - Supplemental material - English language | DOCX",6]