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Comprehensive imaging supports anatomical research and pathology studies beyond what is possible with limited-field methods.","Answer",{"name":111,"@type":106,"acceptedAnswer":112},"What limitations constrained earlier microscopic-resolution MRI studies?",{"text":113,"@type":109},"The spinal cord’s elongated shape and hardware and scan-time limitations restricted earlier microscopic-resolution MRI to only small sections, for both in vivo and ex vivo studies.",{"name":115,"@type":106,"acceptedAnswer":116},"What does the presented postmortem MRM dataset enable?",{"text":117,"@type":109},"The dataset supports spinal cord lesion detection, automated volumetric gray matter segmentation, and quantitative morphometry such as cross-sectional dimensions and gray matter fraction along the cord.","https://schema.org",{"og:url":78,"og:type":120,"og:title":59,"og:site_name":91,"og:description":61},"article",{"robots":122,"canonical":78},"index,follow",{"doc_id":124,"site_id":56},241326,1789173705,{"code":4,"msg":5,"data":127},{"doc_id":124,"user_id":128,"nickname":88,"user_avatar":129,"doc_module":9,"category_id":50,"category_name":51,"doc_title":59,"doc_description":61,"doc_content":130,"file_id":131,"file_url":132,"file_type":133,"file_size":134,"view_count":76,"is_deleted":4,"is_public":9,"is_downloadable":9,"audit_status":9,"page_count":135,"language":136,"language_code":57,"site_id":56,"html_lang":57,"table_of_contents":137,"faqs":138,"seo_title":139,"seo_description":61,"update_tm":125,"read_time":79},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","| |  | |\n| --- | --- | --- |\n\nTitre:  Postmortem diffusion MRI of the entire human spinal cord at Title:  microscopic resolution  \nAuteurs:  Evan Calabrese, Syed M. Adil, Gary Cofer, Christian S. Perone, Julien Authors:  Cohen-Adad, Shivanand P. Lad, & G. Allan Johnson  \nDate:  2018   \n Type:  Article de revue / Article   Calabrese, E. , Adil, S. M. , Cofer, G. , Perone, C. S. , Cohen-Adad, J. , Lad, S. P. , &  \nRéférence: Johnson, G. A. (2018) . Postmortem diffusion MRI of the entire human spinal cord Citation: at microscopic resolution. NeuroImage: Clinical, 18, 963-971.  \n  [https://doi.org/10.1016/j. nicl.2018.03.029](https://doi.org/10.1016/j. nicl.2018.03.029)   \n\n| Document en libre accès dans PolyPublie\u003Cbr>Open Access document in PolyPublie\u003Cbr>|  |  |\n| --- | --- | --- |\n| URL de PolyPublie:\u003Cbr>PolyPublie URL: | [https://publications.polymtl.ca/4813/](https://publications.polymtl.ca/4813/) |  |\n|  Version officielle de l'éditeur / Published version\u003Cbr>Version: \u003Cbr> Révisé par les pairs / Refereed\u003Cbr>|  | |\n| Conditions d’utilisation:\u003Cbr>Terms of Use: | Creative Commons Attribution-Utilisation non commerciale-Pas\u003Cbr>d'oeuvre dérivée 4.0 International / Creative Commons AttributionNonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND)   |  |\n\n\n| Document publié chez l’éditeur officiel\u003Cbr>Document issued by the official publisher\u003Cbr>|  |  |\n| --- | --- | --- |\n| Titre de la revue:\u003Cbr>Journal Title: | NeuroImage: Clinical (vol. 18) |  |\n| Maison d’édition:\u003Cbr>Publisher: | Elsevier |  |\n| URL officiel:\u003Cbr>Official URL:\u003Cbr>| [https://doi.org/10.1016/j. nicl.2018.03.029](https://doi.org/10.1016/j. nicl.2018.03.029)\u003Cbr>| |\n| Mention légale:\u003Cbr> Legal notice: |  |  |\n\nCe fichier a été téléchargé à partir de PolyPublie, le dépôt institutionnel de Polytechnique Montréal  \nThis file has been downloaded from PolyPublie, the institutional repository of Polytechnique Montréal  \n[https://publications.polymtl.ca](https://publications.polymtl.ca)  \nNeuroImage: Clinical 18 (2018) 963–971  \nContents lists available at ScienceDirect  \nNeuroImage: Clinical  \njournal [homepage:](homepage: www.elsevier.com/locate/ynicl)[ www.elsevier.com/locate/ynicl](homepage: www.elsevier.com/locate/ynicl)  \nPostmortem diffusion MRI of the entire human spinal cord at microscopic resolution  \nEvan Calabresea,b,⁎, Syed M. Adilb,d, Gary Coferb, Christian S. Peronec, Julien Cohen-Adadc, Shivanand P. Ladd, G. Allan Johnsonb  \na Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA b Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, USA  \ncNeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada d Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA  \nA R T I C L E I N F O  \nKeywords:  \nSpinal cord  \nMagnetic resonance microscopy Tractography  \nHuman  \nGray matter  \nA B S T R A C T  \nThe human spinal cord is a central nervous system structure that plays an important role in normal motor and sensory function, and can be affected by many debilitating neurologic diseases. Due to its clinical importance, the spinal cord is frequently the subject of imaging research. Common methods for visualizing spinal cord anatomy and pathology include histology and magnetic resonance imaging (MRI), both of which have unique benefits and drawbacks. Postmortem microscopic resolution MRI of fixed specimens, sometimes referred to as magnetic resonance microscopy (MRM), combines many of the benefits inherent to both techniques. However, the elongated shape of the human spinal cord, along with hardware and scan time limitations, have restricted previous microscopic resolution MRI studies (both in vivo and ex vivo) to small sections of the cord. Here we present the first MRM dataset of the entire postmortem human spinal cord. These data include 50 μm isotropic resolution anatomic image data and 100 μm isotropic resolution diffusion data, made possib","cbCaifEApkjPlANe","https://ap.wps.com/l/cbCaifEApkjPlANe","pdf",1232415,10,"English","# Introduction\n## Background and clinical relevance of spinal cord imaging\n## Limits of histology and conventional MRI\n## Rationale for postmortem microscopic resolution MRI","[{\"question\":\"Why is microscopic resolution MRI of the entire human spinal cord important?\",\"answer\":\"The spinal cord is crucial for motor and sensory function and is affected by many neurologic diseases. Comprehensive imaging supports anatomical research and pathology studies beyond what is possible with limited-field methods.\"},{\"question\":\"What limitations constrained earlier microscopic-resolution MRI studies?\",\"answer\":\"The spinal cord’s elongated shape and hardware and scan-time limitations restricted earlier microscopic-resolution MRI to only small sections, for both in vivo and ex vivo studies.\"},{\"question\":\"What does the presented postmortem MRM dataset enable?\",\"answer\":\"The dataset supports spinal cord lesion detection, automated volumetric gray matter segmentation, and quantitative morphometry such as cross-sectional dimensions and gray matter fraction along the cord.\"}]","Postmortem diffusion MRI of the entire human spinal cord at microscopic resolution | PDF"]