[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-1-en-105":3,"doc-seo-563223-105":53,"doc-detail-563223-en":126},{"code":4,"msg":5,"data":6},0,"success",[7,14,19,24,29,34,39,44,49],{"id":8,"doc_module":9,"doc_module_name":10,"category_name":11,"show_sort_weight":12,"slug":13},11,1,"Template","Presentations",90,"presentations",{"id":15,"doc_module":9,"doc_module_name":10,"category_name":16,"show_sort_weight":17,"slug":18},12,"Resumes",80,"resumes",{"id":20,"doc_module":9,"doc_module_name":10,"category_name":21,"show_sort_weight":22,"slug":23},14,"Invoices",70,"invoices",{"id":25,"doc_module":9,"doc_module_name":10,"category_name":26,"show_sort_weight":27,"slug":28},15,"Posters",60,"posters",{"id":30,"doc_module":9,"doc_module_name":10,"category_name":31,"show_sort_weight":32,"slug":33},16,"Social Media",50,"social-media",{"id":35,"doc_module":9,"doc_module_name":10,"category_name":36,"show_sort_weight":37,"slug":38},17,"Forms",40,"forms",{"id":40,"doc_module":9,"doc_module_name":10,"category_name":41,"show_sort_weight":42,"slug":43},18,"Letters",30,"letters",{"id":45,"doc_module":9,"doc_module_name":10,"category_name":46,"show_sort_weight":47,"slug":48},21,"Paper Templates",5,"papers-templates",{"id":50,"doc_module":9,"doc_module_name":10,"category_name":51,"show_sort_weight":4,"slug":52},158,"General","general-158",{"code":4,"msg":54,"data":55},"ok",{"site_id":56,"language":57,"slug":58,"title":59,"keywords":60,"description":61,"schema_data":62,"social_meta":119,"head_meta":121,"extra_data":123,"updated_unix":125},105,"en","open-access-research-clinical-characteristics-and-outcomes-in-patients-with-heart-failure-and-mid-range-ejection-fraction-hfmref","Open Access Research - Clinical characteristics and outcomes in patients with heart failure and mid-range ejection fraction (HFmrEF)","","A multicentre prospective observational study assessed baseline characteristics and outcomes of patients with heart failure and mid-range left ventricular ejection fraction (HFmrEF, LVEF 40%–49%) and evaluated the impact of 1-year LVEF change. Four university hospitals with dedicated HF units followed ambulatory patients, where 14% (n=504) had HFmrEF. Primary outcomes were all-cause death, HF hospitalisation, and a composite endpoint. Mortality and composite outcomes were not different among HFpEF, HFmrEF, and HFrEF after multivariable Cox analyses, while evolving from HFmrEF to HFpEF related to better survival.",{"@graph":63,"@context":118},[64,80,101],{"@type":65,"itemListElement":66},"BreadcrumbList",[67,71,74,77],{"item":68,"name":69,"@type":70,"position":9},"https://docshare.wps.com","Home","ListItem",{"item":72,"name":10,"@type":70,"position":73},"https://docshare.wps.com/template/",2,{"item":75,"name":51,"@type":70,"position":76},"https://docshare.wps.com/template/general/",3,{"item":78,"name":59,"@type":70,"position":79},"https://docshare.wps.com/template/open-access-research-clinical-characteristics-and-outcomes-in-patients-with-heart-failure-and-mid-range-ejection-fraction-hfmref/563223/",4,{"url":78,"name":59,"@type":81,"image":82,"author":87,"headline":59,"publisher":90,"fileFormat":93,"inLanguage":57,"description":61,"dateModified":94,"datePublished":95,"encodingFormat":93,"isAccessibleForFree":96,"interactionStatistic":97},"DigitalDocument",{"url":83,"@type":84,"width":85,"height":86},"https://docshare.wps.com/thumbnails/open-access-research-clinical-characteristics-and-outcomes-in-patients-with-heart-failure-and-mid-range-ejection-fraction-hfmref/563223.png","ImageObject",442,249,{"name":88,"@type":89},"anakgang17","Person",{"url":68,"name":91,"@type":92},"DocShare","Organization","application/pdf","2026-10-30","2026-10-12",true,{"@type":98,"interactionType":99,"userInteractionCount":79},"InteractionCounter",{"@type":100},"ViewAction",{"@type":102,"mainEntity":103},"FAQPage",[104,110,114],{"name":105,"@type":106,"acceptedAnswer":107},"What was the study objective regarding HFmrEF?","Question",{"text":108,"@type":109},"The study analyzed baseline characteristics and outcomes in HFmrEF patients and assessed how a 1-year change in LVEF affected outcomes.","Answer",{"name":111,"@type":106,"acceptedAnswer":112},"What were the primary outcomes?",{"text":113,"@type":109},"Primary outcomes were all-cause death, HF hospitalisation, and a composite end-point.",{"name":115,"@type":106,"acceptedAnswer":116},"Did changes in LVEF over 1 year improve outcomes?",{"text":117,"@type":109},"As a continuous variable, LVEF change was not associated with better outcomes; however, patients who evolved from HFmrEF to HFpEF showed better outcomes.","https://schema.org",{"og:url":78,"og:type":120,"og:title":59,"og:site_name":91,"og:description":61},"article",{"robots":122,"canonical":78},"index,follow",{"doc_id":124,"site_id":56},563223,1792546164,{"code":4,"msg":5,"data":127},{"doc_id":124,"user_id":128,"nickname":88,"user_avatar":129,"doc_module":9,"category_id":50,"category_name":51,"doc_title":59,"doc_description":61,"doc_content":130,"file_id":131,"file_url":132,"file_type":133,"file_size":134,"view_count":79,"is_deleted":4,"is_public":9,"is_downloadable":9,"audit_status":9,"page_count":135,"language":136,"language_code":57,"site_id":56,"html_lang":57,"table_of_contents":137,"faqs":138,"seo_title":139,"seo_description":61,"update_tm":140,"read_time":76},962090883568,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Open Access Research  \n Clinical characteristics, one-year change  \nin ejection fraction and long-term outcomes in patients with heart failure with mid-range ejection fraction: amulticentre prospective observational study in Catalonia (Spain)  \nNuria Farré,1,2,3 Josep Lupon,3,4,5 Eulàlia Roig,3,5,6 Jose Gonzalez-Costello,7,8 Joan Vila,9,10 Silvia Perez,5,9 Marta de Antonio,4 Eduard Solé-González,3,5,6 Cristina Sánchez-Enrique,7,8 Pedro Moliner,4 Sonia Ruiz,1,2 C Enjuanes,2,8,7,11 Sonia Mirabet,3,5,6 Antoni Bayés-Genís,3,4,5 Josep Comin-Colet,2,8,7,11 on behalf of the GICCAT Investigators  \nTo cite: Farré N, Lupon J, Roig E, et al. Clinical characteristics, one-year change in ejection fraction and longterm outcomes in patients with heart failure with mid-range ejection fraction: a multicentre prospective observational study in Catalonia (Spain) . BMJ Open 2017;7:e018719 . doi:10 . 1136/ bmjopen-2017-018719  \n► Prepublication history and additional material for this paper are available online. To view these files, please visit the journal online([http://dx.doi](http://dx.doi). org/10.1136/bmjopen-2017- 018719) .  \nReceived 18 July 2017 Revised 8 September 2017 Accepted 29 September 2017  \nFor numbered affiliations see end of article.  \nCorrespondence to  \nDr Nuria Farré;  \nNFarreLopez@parcdesalutmar. cat  \nAbstrACt  \nObjectives The aim of this study was to analyse baseline characteristics and outcome of patients with heart failure and mid-range left ventricular ejection fraction (HFmrEF, left ventricular ejection fraction (LVEF) 40%–49%) and the effect of 1-year change in LVEF in this group.  \nsetting Multicentre prospective observational study of ambulatory patients with HF followed up at four university hospitals with dedicated HF units.  \nParticipants Fourteen per cent (n=504) of the 3580 patients included had HFmrEF.  \nInterventions Baseline characteristics, 1-year LVEF and outcomes were collected. All-cause death, HF hospitalisation and the composite end-point were the primary outcomes.  \nresults Median follow-up was 3.66 (1 .69–6.04) years. All-cause death, HF hospitalisation and the composite endpoint were 47%, 35% and 59%, respectively. Outcomes were worse in HF with preserved ejection fraction (HFpEF)(LVEF>50%), without differences between HF with reduced ejection fraction (HFrEF) (LVEF\u003C40%) and HFmrEF (allcause mortality 52 .6% vs 45 .8% and 43 .8%, respectively, P=0 .001) . After multivariable Cox regression analyses, no differences in all-cause death and the composite end-point were seen between the three groups. HF hospitalisation and cardiovascular death were not statistically different between patients with HFmrEF and HFrEF. At 1-year followup, 62% of patients with HFmrEF had LVEF measured:  \n24% had LVEF\u003C40%, 43% maintained LVEF 40%–49% and 33% had LVEF>50% . While change in LVEF as continuous variable was not associated with better outcomes, those patients who evolved from HFmrEF to HFpEF did have a better outcome. Those who remained in the HFmrEFand HFrEF groups had higher all-cause mortality after adjustment for age, sex and baseline LVEF (HR 1.96 (95% CI 1.08 to 3 .54, P=0 .027) and HR 2.01 (95% CI 1.04 to 3.86, P=0 .037), respectively) .  \nstrengths and limitations of this study  \n► Cohort study of patients with heart failure (HF) followed up at four hospitals with a dedicated HF unit, thereby reflecting different clinical practice within guidelines recommendations.  \n► The hospitals varied from community-oriented hospitals to reference centres with transplant and ventricular assist devices programmes. The inclusion of hospitals with different levels of complexity determined that baseline characteristics of patients were different among the four hospitals, which allows an easier generalisation of the results.  \n► Not all patients had an echocardiogram during follow-up, which might have resulted in a bias and affected the results.  \nConclusions Patients with HFmrEF have a clinical profile in-between HFpEF and","cbCaiqjQ0SeyJeSv","https://ap.wps.com/l/cbCaiqjQ0SeyJeSv","pdf",716136,9,"English","# Abstract\n## Objectives\n## Setting\n## Participants\n## Interventions\n## Results\n## Strengths and limitations\n## Conclusions\n# Introduction","[{\"question\":\"What was the study objective regarding HFmrEF?\",\"answer\":\"The study analyzed baseline characteristics and outcomes in HFmrEF patients and assessed how a 1-year change in LVEF affected outcomes.\"},{\"question\":\"What were the primary outcomes?\",\"answer\":\"Primary outcomes were all-cause death, HF hospitalisation, and a composite end-point.\"},{\"question\":\"Did changes in LVEF over 1 year improve outcomes?\",\"answer\":\"As a continuous variable, LVEF change was not associated with better outcomes; however, patients who evolved from HFmrEF to HFpEF showed better outcomes.\"}]","Open Access Research - Clinical characteristics and outcomes in patients with heart failure and mid-range ejection fraction (HFmrEF) | PDF",1791822107]