[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-1-en-105":3,"doc-seo-563275-105":53,"doc-detail-563275-en":127},{"code":4,"msg":5,"data":6},0,"success",[7,14,19,24,29,34,39,44,49],{"id":8,"doc_module":9,"doc_module_name":10,"category_name":11,"show_sort_weight":12,"slug":13},11,1,"Template","Presentations",90,"presentations",{"id":15,"doc_module":9,"doc_module_name":10,"category_name":16,"show_sort_weight":17,"slug":18},12,"Resumes",80,"resumes",{"id":20,"doc_module":9,"doc_module_name":10,"category_name":21,"show_sort_weight":22,"slug":23},14,"Invoices",70,"invoices",{"id":25,"doc_module":9,"doc_module_name":10,"category_name":26,"show_sort_weight":27,"slug":28},15,"Posters",60,"posters",{"id":30,"doc_module":9,"doc_module_name":10,"category_name":31,"show_sort_weight":32,"slug":33},16,"Social Media",50,"social-media",{"id":35,"doc_module":9,"doc_module_name":10,"category_name":36,"show_sort_weight":37,"slug":38},17,"Forms",40,"forms",{"id":40,"doc_module":9,"doc_module_name":10,"category_name":41,"show_sort_weight":42,"slug":43},18,"Letters",30,"letters",{"id":45,"doc_module":9,"doc_module_name":10,"category_name":46,"show_sort_weight":47,"slug":48},21,"Paper Templates",5,"papers-templates",{"id":50,"doc_module":9,"doc_module_name":10,"category_name":51,"show_sort_weight":4,"slug":52},158,"General","general-158",{"code":4,"msg":54,"data":55},"ok",{"site_id":56,"language":57,"slug":58,"title":59,"keywords":60,"description":61,"schema_data":62,"social_meta":120,"head_meta":122,"extra_data":124,"updated_unix":126},105,"en","normal-values-of-corrected-heart-rate-variability-in-10-second-electrocardiograms-for-all-ages","Normal Values of Corrected Heart-Rate Variability in 10-Second Electrocardiograms for All Ages","","Heart-rate variability (HRV) measured on standard 10-second electrocardiograms is linked to cardiac and all-cause mortality, yet age- and sex-dependent normal values have been unclear because heart rate affects HRV. Using five Netherlands population studies, the authors derived comprehensive normal ranges for heart-rate corrected HRV in children and adults. Quality control yielded 13,943 ECGs. Corrected SDNNc and RMSSDc normal limits changed systematically with age, informing clinical use and future research.",{"@graph":63,"@context":119},[64,80,102],{"@type":65,"itemListElement":66},"BreadcrumbList",[67,71,74,77],{"item":68,"name":69,"@type":70,"position":9},"https://docshare.wps.com","Home","ListItem",{"item":72,"name":10,"@type":70,"position":73},"https://docshare.wps.com/template/",2,{"item":75,"name":51,"@type":70,"position":76},"https://docshare.wps.com/template/general/",3,{"item":78,"name":59,"@type":70,"position":79},"https://docshare.wps.com/template/normal-values-of-corrected-heart-rate-variability-in-10-second-electrocardiograms-for-all-ages/563275/",4,{"url":78,"name":59,"@type":81,"image":82,"author":87,"headline":59,"publisher":90,"fileFormat":93,"inLanguage":57,"description":61,"dateModified":94,"datePublished":95,"encodingFormat":93,"isAccessibleForFree":96,"interactionStatistic":97},"DigitalDocument",{"url":83,"@type":84,"width":85,"height":86},"https://docshare.wps.com/thumbnails/normal-values-of-corrected-heart-rate-variability-in-10-second-electrocardiograms-for-all-ages/563275.png","ImageObject",442,249,{"name":88,"@type":89},"Malam Tenang","Person",{"url":68,"name":91,"@type":92},"DocShare","Organization","application/pdf","2026-10-29","2026-10-12",true,{"@type":98,"interactionType":99,"userInteractionCount":101},"InteractionCounter",{"@type":100},"ViewAction",6,{"@type":103,"mainEntity":104},"FAQPage",[105,111,115],{"name":106,"@type":107,"acceptedAnswer":108},"Why were age- and sex-dependent normal HRV values needed for 10-second ECGs?","Question",{"text":109,"@type":110},"Because HRV measured on 10-second ECGs is associated with mortality risk, but normal reference values that account for age and sex were not established. Heart rate strongly influences HRV, so correction is necessary.","Answer",{"name":112,"@type":107,"acceptedAnswer":113},"How were the corrected HRV values derived in the study?",{"text":114,"@type":110},"Five Netherlands population studies provided 10-second, 12-lead ECGs. After quality control, 13,943 ECGs were analyzed using well-validated software, and heart-rate correction formulas were derived with an exponential model.",{"name":116,"@type":107,"acceptedAnswer":117},"Which HRV markers were analyzed, and how did normal limits vary with age?",{"text":118,"@type":110},"Two time-domain markers were analyzed: corrected SDNNc and corrected RMSSDc. For both, the median and the lower normal limit decreased from birth to old age, while the upper limit decreased until about age 60 and then increased after.","https://schema.org",{"og:url":78,"og:type":121,"og:title":59,"og:site_name":91,"og:description":61},"article",{"robots":123,"canonical":78},"index,follow",{"doc_id":125,"site_id":56},563275,1792124884,{"code":4,"msg":5,"data":128},{"doc_id":125,"user_id":129,"nickname":88,"user_avatar":130,"doc_module":9,"category_id":50,"category_name":51,"doc_title":59,"doc_description":61,"doc_content":131,"file_id":132,"file_url":133,"file_type":134,"file_size":135,"view_count":101,"is_deleted":4,"is_public":9,"is_downloadable":9,"audit_status":9,"page_count":136,"language":137,"language_code":57,"site_id":56,"html_lang":57,"table_of_contents":138,"faqs":139,"seo_title":140,"seo_description":61,"update_tm":141,"read_time":76},962093532863,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Edited by:  \nMark Potse,  \nInria Bordeaux-Sud-Ouest Research Centre, France  \nReviewed by:  \nBas J. Boukens, University of Amsterdam, Netherlands  \nJulia Ramirez Garcia, Queen Mary University of London, United Kingdom  \nAna Minchole, University of Oxford, United Kingdom  \n*Correspondence:  \nJanA. Kors[j.kors@erasmusmc.nl](j.kors@erasmusmc.nl)  \nSpecialty section:  \nThis article was submitted to Cardiac Electrophysiology, a section of the journal Frontiers in Physiology  \nReceived: 22 March 2017  \nAccepted: 05 April 2018  \nPublished: 27 April 2018  \nCitation:  \nvan den Berg ME, Rijnbeek PR, Niemeijer MN, Hofman A, van Herpen G, Bots ML, Hillege H, Swenne CA, Eijgelsheim M, Stricker BH and Kors JA (2018)  \nNormal Values of Corrected Heart-Rate Variability in 10-Second Electrocardiograms for All Ages.  \nFront. Physiol. 9:424.  \ndoi: 10.3389/fphys.2018.00424  \nNormal Values of Corrected Heart-Rate Variability in 10-Second Electrocardiograms for All Ages  \nMarten E. van den Berg 1, Peter R. Rijnbeek1, Maartje N. Niemeijer2, Albert Hofman2,  \nGerard van Herpen 1, Michiel L. Bots3, Hans Hillege4, CeesA. Swenne5, Mark Eijgelsheim2,6, Bruno H. Stricker2,7,8 and Jan A. Kors 1*  \n1 Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands, 2 Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands, 3 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands, 4 Department of Cardiology, University Medical Center Groningen, Groningen, Netherlands, 5 Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands,  \n6 Department of Internal Medicine, University Medical Center Groningen, Groningen, Netherlands, 7 Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands, 8 Health and Youth Care Inspectorate, Utrecht, Netherlands  \nPurpose: Heart-rate variability (HRV) measured on standard 10-s electrocardiograms (ECGs) has been associated with increased risk of cardiac and all-cause mortality, but age- and sex-dependent normal values have not been established. Since heart rate strongly affects HRV, its effect should be taken into account. We determined a comprehensive set of normal values of heart-rate corrected HRV derived from 10-s ECGs for both children and adults, covering both sexes.  \nMethods: Five population studies in the Netherlands (Pediatric Normal ECG Study, Leiden University Einthoven Science Project, Prevention of Renal and Vascular Endstage Disease Study, Utrecht Health Project, Rotterdam Study) provided 10-s, 12-lead ECGs. ECGs were stored digitally and analyzed by well-validated analysis software. We included cardiologically healthy participants, 42% being men. Their ages ranged from 11 days to 91 years. After quality control, 13,943 ECGs were available. Heart-rate correction formulas were derived using an exponential model. Two time-domain HRV markers were analyzed: the corrected standard deviation of the normal-to-normal RR intervals (SDNNc) and corrected root mean square of successive RR-interval differences (RMSSDc) .  \nResults: There was a considerable age effect. For both SDNNc and RMSSDc, the median and the lower limit of normal decreased steadily from birth until old age. The upper limit of normal decreased until the age of 60, but increased markedly after that age. Differences of the median were minimal between men and women.  \nConclusion: We report the first comprehensive set of normal values for heart-rate corrected 10-s HRV, which can be of value in clinical practice and in further research.  \nKeywords: electrocardiography, heart-rate variability, normal values, heart-rate correction, children, adults, elderly  \nINTRODUCTION  \nHeart-rate variability (HRV) as measured on the electrocardiogram (ECG) is the variability of intervals between QRS complexes generated by sinus node depolarization in one continuous recording (Task Force of the European Society of","cbCaib7Qf8M3hLJY","https://ap.wps.com/l/cbCaib7Qf8M3hLJY","pdf",2591159,9,"English","# Purpose\n# Methods\n# Results\n# Conclusion\n# Introduction","[{\"question\":\"Why were age- and sex-dependent normal HRV values needed for 10-second ECGs?\",\"answer\":\"Because HRV measured on 10-second ECGs is associated with mortality risk, but normal reference values that account for age and sex were not established. Heart rate strongly influences HRV, so correction is necessary.\"},{\"question\":\"How were the corrected HRV values derived in the study?\",\"answer\":\"Five Netherlands population studies provided 10-second, 12-lead ECGs. After quality control, 13,943 ECGs were analyzed using well-validated software, and heart-rate correction formulas were derived with an exponential model.\"},{\"question\":\"Which HRV markers were analyzed, and how did normal limits vary with age?\",\"answer\":\"Two time-domain markers were analyzed: corrected SDNNc and corrected RMSSDc. For both, the median and the lower normal limit decreased from birth to old age, while the upper limit decreased until about age 60 and then increased after.\"}]","Normal Values of Corrected Heart-Rate Variability in 10-Second Electrocardiograms for All Ages | PDF",1791825852]