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The research investigates copy number alterations (CNAs) across different breast cancer subtypes, including Basal-like, HER2, Luminal A, and Luminal B, as visualized in circular plots (Figure 1A). Aneuploidy scores and CIN70 scores are analyzed in relation to these subtypes and clinical data, revealing significant differences and correlations (Figures 1B, 1C). The study also examines the relationship between ER status and CIN70 score (Figure 1D). Furthermore, differential gene expression analysis is performed by comparing various breast cancer conditions, such as ploidy high vs. ploidy low (Figure 1E) and CIN70 high vs. CIN70 low (Figure 1F), using Venn diagrams to illustrate overlapping genes. The document then delves into the development and validation of prognostic models, likely based on lncRNA expression, to predict patient outcomes. This includes survival analysis and receiver operating characteristic (ROC) curve analysis to assess the performance of risk stratification models in different datasets (Figures 2A-H). The findings aim to improve the understanding of breast cancer heterogeneity and provide tools for more accurate clinical prognostication and personalized treatment strategies.",{"@graph":63,"@context":119},[64,80,102],{"@type":65,"itemListElement":66},"BreadcrumbList",[67,71,74,77],{"item":68,"name":69,"@type":70,"position":9},"https://docshare.wps.com","Home","ListItem",{"item":72,"name":10,"@type":70,"position":73},"https://docshare.wps.com/template/",2,{"item":75,"name":51,"@type":70,"position":76},"https://docshare.wps.com/template/general/",3,{"item":78,"name":59,"@type":70,"position":79},"https://docshare.wps.com/template/multimodal-analysis-of-breast-cancer-subtypes-and-clinical-prognostication/195290/",4,{"url":78,"name":59,"@type":81,"image":82,"author":87,"headline":59,"publisher":90,"fileFormat":93,"inLanguage":57,"description":61,"dateModified":94,"datePublished":95,"encodingFormat":93,"isAccessibleForFree":96,"interactionStatistic":97},"DigitalDocument",{"url":83,"@type":84,"width":85,"height":86},"https://docshare.wps.com/thumbnails/multimodal-analysis-of-breast-cancer-subtypes-and-clinical-prognostication/195290.png","ImageObject",442,249,{"name":88,"@type":89},"Maeve","Person",{"url":68,"name":91,"@type":92},"DocShare","Organization","application/pdf","2026-09-27","2026-09-03",true,{"@type":98,"interactionType":99,"userInteractionCount":101},"InteractionCounter",{"@type":100},"ViewAction",6,{"@type":103,"mainEntity":104},"FAQPage",[105,111,115],{"name":106,"@type":107,"acceptedAnswer":108},"What are the main breast cancer subtypes investigated in this study?","Question",{"text":109,"@type":110},"The study investigates Basal-like, HER2, Luminal A, and Luminal B breast cancer subtypes.","Answer",{"name":112,"@type":107,"acceptedAnswer":113},"What types of genomic alterations are analyzed?",{"text":114,"@type":110},"The study analyzes copy number alterations, specifically deletions and duplications, across different breast cancer subtypes.",{"name":116,"@type":107,"acceptedAnswer":117},"What is the purpose of developing prognostic models in this research?",{"text":118,"@type":110},"The prognostic models are developed to predict patient outcomes and stratify risk based on molecular features, likely lncRNA expression, to aid in clinical prognostication and personalized treatment.","https://schema.org",{"og:url":78,"og:type":121,"og:title":59,"og:site_name":91,"og:description":61},"article",{"robots":123,"canonical":78},"index,follow",{"doc_id":125,"site_id":56},195290,1790200749,{"code":4,"msg":5,"data":128},{"doc_id":125,"user_id":129,"nickname":88,"user_avatar":130,"doc_module":9,"category_id":50,"category_name":51,"doc_title":59,"doc_description":61,"doc_content":60,"file_id":131,"file_url":132,"file_type":133,"file_size":134,"view_count":101,"is_deleted":4,"is_public":9,"is_downloadable":9,"audit_status":9,"page_count":135,"language":136,"language_code":57,"site_id":56,"html_lang":57,"table_of_contents":137,"faqs":138,"seo_title":139,"seo_description":61,"update_tm":140,"read_time":47},5909877438554,"https://ap-avatar.wpscdn.com/avatar/5600025385ad2bf12a7?_k=1778553567797529272","cbCaif22JmHgIEuo","https://ap.wps.com/l/cbCaif22JmHgIEuo","pdf",7131906,13,"English","# Genomic and Diploid Aberrations in Breast Cancer Subtypes\n## Aneuploidy Score Analysis\n## CIN70 Score Analysis\n## ER Status and CIN70 Score Correlation\n## Differential Gene Expression Analysis\n## Prognostic Model Development and Validation\n### Training Set Analysis\n### Testing Set Analysis\n### TCGA Dataset Analysis","[{\"question\":\"What are the main breast cancer subtypes investigated in this study?\",\"answer\":\"The study investigates Basal-like, HER2, Luminal A, and Luminal B breast cancer subtypes.\"},{\"question\":\"What types of genomic alterations are analyzed?\",\"answer\":\"The study analyzes copy number alterations, specifically deletions and duplications, across different breast cancer subtypes.\"},{\"question\":\"What is the purpose of developing prognostic models in this research?\",\"answer\":\"The prognostic models are developed to predict patient outcomes and stratify risk based on molecular features, likely lncRNA expression, to aid in clinical prognostication and personalized treatment.\"}]","Multimodal analysis of breast cancer subtypes and clinical prognostication | PDF",1788447134]