[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-190802-105":3,"detail-sidebar-cat-1-en-105":81,"doc-detail-190802-en":126},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","management-options-for-refractory-acne","Management Options for Refractory Acne","","Management options for refractory acne focus on patients of all ages whose acne vulgaris has not responded to prior treatment for the same episode. The interventions cover topical agents, oral antibiotics, oral isotretinoin, hormonal and hormone-modifying therapies, and physical approaches such as chemical peels, comedone extraction, and energy-based device treatments. Effectiveness is assessed through clinician-rated improvement in lesion count and acne severity, prevention of scarring, and participant-reported symptom changes. Acceptability, tolerability, relapse, and side-effect–related discontinuations are also tracked.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/template/","Template",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/template/general/","General",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/template/management-options-for-refractory-acne/190802/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/management-options-for-refractory-acne/190802.png","ImageObject",442,249,{"name":42,"@type":43},"Ezra","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-09-29","2026-09-03",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",5,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Who is included as the population for refractory acne management options?","Question",{"text":63,"@type":64},"People of all ages whose acne vulgaris has not responded to previous treatment for the same episode are included.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What intervention types are considered in refractory acne?",{"text":68,"@type":64},"Interventions include topical treatments, oral antibiotics, oral isotretinoin, hormonal and hormone-modifying agents, and physical treatments such as chemical peels, comedone extraction, and energy-based device therapies.",{"name":70,"@type":61,"acceptedAnswer":71},"How are outcomes such as improvement and scarring evaluated?",{"text":72,"@type":64},"Outcomes include clinician-rated improvement via percentage lesion-count change and validated severity scale scores, prevention of scarring via scar-count changes or incidence, and participant-reported improvement using acne severity or symptom measures.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},190802,1788405049,{"code":4,"msg":82,"data":83},"success",[84,89,94,99,104,109,114,119,123],{"id":85,"doc_module":22,"doc_module_name":25,"category_name":86,"show_sort_weight":87,"slug":88},11,"Presentations",90,"presentations",{"id":90,"doc_module":22,"doc_module_name":25,"category_name":91,"show_sort_weight":92,"slug":93},12,"Resumes",80,"resumes",{"id":95,"doc_module":22,"doc_module_name":25,"category_name":96,"show_sort_weight":97,"slug":98},14,"Invoices",70,"invoices",{"id":100,"doc_module":22,"doc_module_name":25,"category_name":101,"show_sort_weight":102,"slug":103},15,"Posters",60,"posters",{"id":105,"doc_module":22,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},16,"Social Media",50,"social-media",{"id":110,"doc_module":22,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},17,"Forms",40,"forms",{"id":115,"doc_module":22,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},18,"Letters",30,"letters",{"id":120,"doc_module":22,"doc_module_name":25,"category_name":121,"show_sort_weight":55,"slug":122},21,"Paper Templates","papers-templates",{"id":124,"doc_module":22,"doc_module_name":25,"category_name":29,"show_sort_weight":4,"slug":125},158,"general-158",{"code":4,"msg":82,"data":127},{"doc_id":79,"user_id":128,"nickname":42,"user_avatar":129,"doc_module":22,"category_id":124,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":130,"file_id":131,"file_url":132,"file_type":133,"file_size":134,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":135,"language":136,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":137,"faqs":138,"seo_title":139,"seo_description":12,"update_tm":80,"read_time":140},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","| Population | People of all ages whose acne vulgaris has not responded to previous treatment (refractory or resistant acne) for the same episode of acne. |\n| --- | --- |\n| Intervention | • Topical treatments including abrasive/cleaning agents, anthelmintic , antibacterials, antibiotics, antiseptics, dicarboxylic acids, vitamin B3, retinoids or retinoid-like agents, or any combination of these.\u003Cbr>• Oral antibiotics including, for example, carbapenems, cephamycins/cephalosporins, sulphones, fucidic acid, lincosamides, macrolides, monobactams, penicillins, or any combination of these.\u003Cbr>• Oral isotretinoin.\u003Cbr>• Hormonal treatments including (monophasic and phasic) progestogen-only contraceptives, co-cyprindiol, and combined oral contraceptives.\u003Cbr>• Hormone-modifying agents including, for example, aldosterone antagonists (for example, spironolactone), class 5α-reductase inhibitor (for example, dutasteride), other non-steroidal antiandrogens (for example, flutamide), and metformin.\u003Cbr>• Physical treatments including chemical peels (for example, salicylic acid), comedone extraction, and treatments using energy-based devices (for example, photochemical therapy, photodynamic therapy, photopneumatic therapy, photothermal therapy, radiofrequency therapy) . |\n\n\n| Comparison | • Any other active acne treatment\u003Cbr>• No treatment\u003Cbr>• Placebo (for example, vehicle capsule, gel, solution, tablet)\u003Cbr>• Sham physical treatment\u003Cbr>• Wait list |\n| --- | --- |\n| Outcomes | Critical\u003Cbr>• Clinician-rated improvement at treatment endpoint:\u003Cbr>o Percentage change in acne lesion count\u003Cbr>o Change from baseline or final score on a validated acne severity scale.\u003Cbr>• Prevention of scarring at any follow-up:\u003Cbr>o Change from baseline or final number of scars\u003Cbr>o Incidence of scarring.\u003Cbr>• Participant-reported improvement:\u003Cbr>o Change in acne severity or symptoms (for example, assessed using global acne score) .\u003Cbr>Important\u003Cbr>• Acceptability\u003Cbr>o Treatment discontinuation for any reason.\u003Cbr>• Tolerability\u003Cbr>o Treatment discontinuation due to side effects.\u003Cbr>• Relapse\u003Cbr>o Relapse after treatment at follow-up.\u003Cbr>• Side effects\u003Cbr>o Specific short-term side effects for comparisons of treatments within the same class or those that involve an inactive arm (for example, placebo, no or sham treatment) . |","cbCaikVfRqfsRbYF","https://ap.wps.com/l/cbCaikVfRqfsRbYF","pdf",1561632,124,"English","# Population\n## Intervention\n## Comparison\n## Outcomes","[{\"question\":\"Who is included as the population for refractory acne management options?\",\"answer\":\"People of all ages whose acne vulgaris has not responded to previous treatment for the same episode are included.\"},{\"question\":\"What intervention types are considered in refractory acne?\",\"answer\":\"Interventions include topical treatments, oral antibiotics, oral isotretinoin, hormonal and hormone-modifying agents, and physical treatments such as chemical peels, comedone extraction, and energy-based device therapies.\"},{\"question\":\"How are outcomes such as improvement and scarring evaluated?\",\"answer\":\"Outcomes include clinician-rated improvement via percentage lesion-count change and validated severity scale scores, prevention of scarring via scar-count changes or incidence, and participant-reported improvement using acne severity or symptom measures.\"}]","Management Options for Refractory Acne | PDF",43]