[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-1-en-105":3,"doc-seo-307037-105":53,"doc-detail-307037-en":126},{"code":4,"msg":5,"data":6},0,"success",[7,14,19,24,29,34,39,44,49],{"id":8,"doc_module":9,"doc_module_name":10,"category_name":11,"show_sort_weight":12,"slug":13},11,1,"Template","Presentations",90,"presentations",{"id":15,"doc_module":9,"doc_module_name":10,"category_name":16,"show_sort_weight":17,"slug":18},12,"Resumes",80,"resumes",{"id":20,"doc_module":9,"doc_module_name":10,"category_name":21,"show_sort_weight":22,"slug":23},14,"Invoices",70,"invoices",{"id":25,"doc_module":9,"doc_module_name":10,"category_name":26,"show_sort_weight":27,"slug":28},15,"Posters",60,"posters",{"id":30,"doc_module":9,"doc_module_name":10,"category_name":31,"show_sort_weight":32,"slug":33},16,"Social Media",50,"social-media",{"id":35,"doc_module":9,"doc_module_name":10,"category_name":36,"show_sort_weight":37,"slug":38},17,"Forms",40,"forms",{"id":40,"doc_module":9,"doc_module_name":10,"category_name":41,"show_sort_weight":42,"slug":43},18,"Letters",30,"letters",{"id":45,"doc_module":9,"doc_module_name":10,"category_name":46,"show_sort_weight":47,"slug":48},21,"Paper Templates",5,"papers-templates",{"id":50,"doc_module":9,"doc_module_name":10,"category_name":51,"show_sort_weight":4,"slug":52},158,"General","general-158",{"code":4,"msg":54,"data":55},"ok",{"site_id":56,"language":57,"slug":58,"title":59,"keywords":60,"description":61,"schema_data":62,"social_meta":119,"head_meta":121,"extra_data":123,"updated_unix":125},105,"en","lipid-accumulation-in-heart-transplant-from-non-diabetic-donors-to-diabetic-recipients-informed-consent-form","Lipid Accumulation in Heart Transplant From Non-diabetic Donors to Diabetic Recipients - Informed Consent Form","","Informed consent material for a prospective observational study evaluating lipid accumulation and cellular alterations in transplanted hearts from non-diabetic donors to diabetic recipients. The research involves echocardiographic follow-up at defined time points and collection of endo-myocardial biopsies for histopathological rejection assessment, immunohistochemical analysis, PCR evaluation, and ELISA-based quantification. Participation is voluntary, with no direct personal benefit stated, while enrollment is expected to advance understanding of how diabetes affects heart dysfunction and progression in diabetic cardiomyopathy.",{"@graph":63,"@context":118},[64,80,101],{"@type":65,"itemListElement":66},"BreadcrumbList",[67,71,74,77],{"item":68,"name":69,"@type":70,"position":9},"https://docshare.wps.com","Home","ListItem",{"item":72,"name":10,"@type":70,"position":73},"https://docshare.wps.com/template/",2,{"item":75,"name":41,"@type":70,"position":76},"https://docshare.wps.com/template/letters/",3,{"item":78,"name":59,"@type":70,"position":79},"https://docshare.wps.com/template/lipid-accumulation-in-heart-transplant-from-non-diabetic-donors-to-diabetic-recipients-informed-consent-form/307037/",4,{"url":78,"name":59,"@type":81,"image":82,"author":87,"headline":59,"publisher":90,"fileFormat":93,"inLanguage":57,"description":61,"dateModified":94,"datePublished":95,"encodingFormat":93,"isAccessibleForFree":96,"interactionStatistic":97},"DigitalDocument",{"url":83,"@type":84,"width":85,"height":86},"https://docshare.wps.com/thumbnails/lipid-accumulation-in-heart-transplant-from-non-diabetic-donors-to-diabetic-recipients-informed-consent-form/307037.png","ImageObject",442,249,{"name":88,"@type":89},"Aurora","Person",{"url":68,"name":91,"@type":92},"DocShare","Organization","application/pdf","2026-10-07","2026-09-19",true,{"@type":98,"interactionType":99,"userInteractionCount":79},"InteractionCounter",{"@type":100},"ViewAction",{"@type":102,"mainEntity":103},"FAQPage",[104,110,114],{"name":105,"@type":106,"acceptedAnswer":107},"What is the purpose of the research?","Question",{"text":108,"@type":109},"The study evaluates the presence of cellular alterations related to diabetic disease in the diabetic heart and assesses progression of related lesions in transplanted hearts in diabetic patients.","Answer",{"name":111,"@type":106,"acceptedAnswer":112},"What procedures will participants undergo?",{"text":113,"@type":109},"Participants will be followed with echocardiographic evaluations and will have endo-myocardial biopsies collected at scheduled intervals for histopathology, immunohistochemistry, PCR, and ELISA analyses.",{"name":115,"@type":106,"acceptedAnswer":116},"Is participation required, and what happens if a patient declines?",{"text":117,"@type":109},"Participation is entirely voluntary. 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I am doing research on the heart failure in diabetic patients which is very common in this country and in this region. I am going to give you information and invite you to be part of this research. You do not have to decide today whether or not you will participate in the research. Before you decide, you can talk to anyone you feel comfortable with about the research.  \nThis consent form may contain words that you do not understand. Please ask me to stop as we go through the information and I will take time to explain. If you have questions later, you can ask them of me or of another researcher.  \nPurpose of the research  \nDiabetic cardiomyopathy (DCM) is defined by the presence of left ventricular systolic dysfunction in the absence of an abnormal loading condition or significant coronary heart disease. DCM is the leading cause of end-stage heart failure (HF) and is responsible for half of all heart transplants (HTx) . Endocrine disorders, including diabetes, are known to be associated with DCMs. Diabetes mellitus (DM), which is present in 75% of patients with idiopathic DCM, is an independent risk factor for the development of heart failure and death in DCM. Therefore, DM may exacerbate the need for HTx; moreover, diabetic patients are less suitable for HTx and DM remains an independent risk factor for death even after HTx. Recent studies have revealed the presence of diabetic cardiomyopathy, a condition of myocardial dysfunction without coronary heart disease. This term was first introduced by Rubler et al. in 1972, which highlighted patients with diabetes and congestive heart failure with normal coronary arteries. The pathophysiological mechanisms by which diabetes affects the development and progression of diabetic heart disease are not known. Therefore, the aim of our study will be to evaluate, in the diabetic heart removed, the presence of any cellular alterations related to diabetic disease. In addition, the progression of such lesions in the transplanted heart in diabetic patients will be evaluated.  \nType of Research Intervention  \nThis research will involve your participation in a observational prospective study that that it won't change the management of your condition according the guidelines for heart tranplantation  \nParticipant Selection  \nYou are being invited to take part in this research because we feel that the evaluation of your pathology can contribute much to our understanding and knowledge of the effects of diabetes on heart dysfunction. A cohort of consecutive patients (diabetics vs. non-diabetics) with DCM and NYHA class III/IV heart failure refractory to maximum medical therapy and treated with cardiac transplantation at the Division of Cardiac Surgery of the University of Campania \"Luigi Vanvitelli\" will be evaluated prospectively. Atthe Department of Medical Sciences will be conducted the clinical follow-up for cardiometabolic evaluation (eg routine, glycemic compensation) .  \nVoluntary Participation  \nYour participation in this research is entirely voluntary. It is your choice whether to participate or not. If you choose not to participate all the services you receive at this Centre will continue and nothing will change.  \nProcedures  \nYou will be followed through an ","cbCairOFA8iILVH9","https://ap.wps.com/l/cbCairOFA8iILVH9","pdf",258157,"English","# Introduction\n# Purpose of the research\n# Type of Research Intervention\n# Participant Selection\n# Voluntary Participation\n# Procedures\n# Duration\n# Risks\n# Benefits","[{\"question\":\"What is the purpose of the research?\",\"answer\":\"The study evaluates the presence of cellular alterations related to diabetic disease in the diabetic heart and assesses progression of related lesions in transplanted hearts in diabetic patients.\"},{\"question\":\"What procedures will participants undergo?\",\"answer\":\"Participants will be followed with echocardiographic evaluations and will have endo-myocardial biopsies collected at scheduled intervals for histopathology, immunohistochemistry, PCR, and ELISA analyses.\"},{\"question\":\"Is participation required, and what happens if a patient declines?\",\"answer\":\"Participation is entirely voluntary. If a patient chooses not to participate, services at the centre continue and nothing will change.\"}]","Lipid Accumulation in Heart Transplant From Non-diabetic Donors to Diabetic Recipients - Informed Consent Form | PDF",1789843441]