[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-565478-105":3,"detail-sidebar-cat-1-en-105":80,"doc-detail-565478-en":126},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","interpretation-of-serum-human-chorionic-gonadotropin-hcg-results-in-pregnancy","Interpretation of Serum Human Chorionic Gonadotropin (hCG) Results in Pregnancy","","Guidance for interpreting serum human chorionic gonadotropin (hCG) during pregnancy evaluation. Provides reference intervals for non-pregnant persons and expected hCG ranges by weeks of gestation, including method-specific cautions for Roche Cobas testing. Covers hCG concentration doubling time in early normal pregnancies, with expected limits across gestational days, and gives thresholds for expected increases or decreases over two days. Emphasizes that serial values must be interpreted alongside clinical judgment, symptoms, and repeat ultrasound.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/template/","Template",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/template/general/","General",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/template/interpretation-of-serum-human-chorionic-gonadotropin-hcg-results-in-pregnancy/565478/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/interpretation-of-serum-human-chorionic-gonadotropin-hcg-results-in-pregnancy/565478.png","ImageObject",442,249,{"name":42,"@type":43},"Rainbow Cat","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-20","2026-10-13",true,{"@type":52,"interactionType":53,"userInteractionCount":26},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"How do reference intervals for serum hCG differ for non-pregnant people and pregnant females?","Question",{"text":62,"@type":63},"The document lists reference intervals for non-pregnant persons (and separate ranges for males and non-pregnant pre- or post-menopausal females) and then provides expected serum hCG values by completed weeks of gestation for pregnant females.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"What is the expected serum hCG concentration doubling time in early normal pregnancy?",{"text":67,"@type":63},"In the first three weeks of a normal pregnancy, serum hCG approximately doubles every two days. The document provides gestational-day group limits for expected doubling time (e.g., ≤2.2 days for days 9–21, ≤2.6 days for days 21–28, and ≤4.4 days for days 28–36).",{"name":69,"@type":60,"acceptedAnswer":70},"Can serial hCG values alone determine intrauterine pregnancy, miscarriage, or ectopic pregnancy?",{"text":71,"@type":63},"No. The document states that serial hCG values should not be used alone. About 21% of ectopic pregnancies can show an hCG rise similar to an intrauterine pregnancy, and 8% can show an hCG fall similar to miscarriage, so results must be combined with clinical judgment, symptoms, and repeat ultrasound as needed.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},565478,1792501394,{"code":4,"msg":81,"data":82},"success",[83,88,93,98,103,108,113,118,123],{"id":84,"doc_module":22,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},11,"Presentations",90,"presentations",{"id":89,"doc_module":22,"doc_module_name":25,"category_name":90,"show_sort_weight":91,"slug":92},12,"Resumes",80,"resumes",{"id":94,"doc_module":22,"doc_module_name":25,"category_name":95,"show_sort_weight":96,"slug":97},14,"Invoices",70,"invoices",{"id":99,"doc_module":22,"doc_module_name":25,"category_name":100,"show_sort_weight":101,"slug":102},15,"Posters",60,"posters",{"id":104,"doc_module":22,"doc_module_name":25,"category_name":105,"show_sort_weight":106,"slug":107},16,"Social Media",50,"social-media",{"id":109,"doc_module":22,"doc_module_name":25,"category_name":110,"show_sort_weight":111,"slug":112},17,"Forms",40,"forms",{"id":114,"doc_module":22,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},18,"Letters",30,"letters",{"id":119,"doc_module":22,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},21,"Paper Templates",5,"papers-templates",{"id":124,"doc_module":22,"doc_module_name":25,"category_name":29,"show_sort_weight":4,"slug":125},158,"general-158",{"code":4,"msg":81,"data":127},{"doc_id":78,"user_id":128,"nickname":42,"user_avatar":129,"doc_module":22,"category_id":124,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":130,"file_id":131,"file_url":132,"file_type":133,"file_size":134,"view_count":26,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":26,"language":135,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":136,"faqs":137,"seo_title":138,"seo_description":12,"update_tm":139,"read_time":22},962090769181,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","November 2017  \nInterpretation of Serum Human Chorionic Gonadotropin (hCG) Results in Pregnancy  \nThe analysis of serum hCG has been used to confirm a pregnancy, to help diagnose an ectopic pregnancy, to help diagnose and monitor a pregnancy that may be failing, and/or to monitor a woman after a miscarriage. The following information helps to interpret serum hCG results in pregnancy evaluation.  \n\n| Serum hCG Reference Intervals and Expected Values |  |\n| --- | --- |\n| Non-pregnant persons | Reference Interval (IU/L)(2.5-97.5th percentile) |\n| Male | \u003C 3 |\n| Female\u003Cbr>Non-pregnant pre-menopausal:\u003Cbr>Equivocal (may indicate early pregnancy):\u003Cbr>Post-menopausal: | \u003C 5\u003Cbr>5-9\u003Cbr>\u003C 8 |\n| Pregnant females Weeks of gestation 1 : | Expected Values (IU/L)(5-95th percentile) 2 |\n| 3 4\u003Cbr>5 6\u003Cbr>7 8\u003Cbr>9\u003Cbr>10\u003Cbr>12\u003Cbr>14\u003Cbr>15\u003Cbr>16\u003Cbr>17\u003Cbr>18 | 5.8 - 71.2\u003Cbr>9.5 - 750\u003Cbr>217 - 7,138 158 - 31,795\u003Cbr>3,697 - 163,563 32,065 - 149,571 63,803 - 151,410 46,509 - 186,977 27,832 - 210,612 13,950 - 62,530 12,039 - 70,971\u003Cbr>9,040 - 56,451 8,175 - 55,868 8,099 - 58,176 |\n| 1Weeks of gestation is defined as completed weeks of pregnancy beginning with the start of the last menstruation phase.\u003Cbr>2These expected values are specific for hCG tested by the Roche Cobas ® analyzer, the method used by Dynacare [1] . These values should not be used to interpret results from other methods. |  |\n\nSerum Human Chorionic Gonadotropin (hCG) Concentration Doubling Time  \nIn the first three weeks of a normal pregnancy, the serum hCG approximately doubles every two days. The doubling time of hCG is considered a more reliable method of evaluating an early pregnancy than a single serum hCG result [2] .  \n\n| Serum hCG Concentration Doubling Time |  |\n| --- | --- |\n| Days of gestation 1 : | Expected Doubling Time (Days) |\n| 9-21\u003Cbr>21-28\u003Cbr>28-36 | ≤ 2.2\u003Cbr>≤ 2.6\u003Cbr>≤ 4.4 |\n| Doubling Time (Days) = [(log2)×(time interval in days)]/log (hCG2/hCG1)\u003Cbr>Example:\u003Cbr>If the serum hCG from a patient with 24 days of gestation is 400 IU/L and 2 days later is 700, the doubling time is then:\u003Cbr>􀀾(log2)×(2)􀁀/log(700/400) = 0.60/log1.75 = 0.60/0.24 = 2.5 days A doubling time of 2.5 days is normal as it is less than the limit of 2.6 days. |  |\n| 1 Days of gestation is defined as completed days of pregnancy beginning with the start of the last menstruation phase. |  |\n\nIt is expected that the hCG level for a successful intrauterine pregnancy should increase by at least 35% in two days. A slower rate of increase suggests a possible miscarriage or ectopic pregnancy. For women who are having a miscarriage, it is expected that the hCG level should fall 36-47% over two days. A fall that is slower than this is suggestive of an ectopic pregnancy [3] .  \nHowever, serial hCG values should not be used alone to determine whether or not a pregnancy is likely to be a successful intrauterine pregnancy, a miscarriage, or an ectopic pregnancy. About 21% of ectopic pregnancies (pregnancies implanted outside of the uterus) have a rise in hCG similar to an intrauterine pregnancy and 8% of ectopic pregnancies have a fall in hCG similar to a miscarriage. Serial hCG values should be used in combination with clinical judgment, evaluation of symptoms and repeat ultrasound (as needed) .  \nReferences:  \n1. Roche MODULAR ANALYTICS E170 package insert for reagent of intact human chorionic gonadotropin + the β-subunit. 2017-03, V 17.0  \n2. Pittaway, DE and Wentz AC. Evaluation of early pregnancy by serial chorionic gonadotropin determinations: a comparison of methods by receiver operating characteristic curve analysis. Fertil Steril 1985 Apr;43(4):529-33.  \n3. Morse CB, Sammel MD, Shaunik A, et al. Performance of human chorionic gonadotropin curves in women at risk for ectopic pregnancy: exceptions to the rules. Fertil Steril 2012 Jan; 97(1): 101–106.e2 .","cbCaipx8Zg7E9Kou","https://ap.wps.com/l/cbCaipx8Zg7E9Kou","pdf",217906,"English","# Serum hCG reference intervals and expected values\n## Non-pregnant reference ranges\n## Expected values by weeks of gestation\n# Serum hCG concentration doubling time\n## Early pregnancy doubling expectations\n## Doubling time calculation and example\n# Serial hCG change patterns and clinical interpretation\n## Expected increase for viable intrauterine pregnancy\n## Expected fall in miscarriage\n## Limits of using serial hCG alone\n# References","[{\"question\":\"How do reference intervals for serum hCG differ for non-pregnant people and pregnant females?\",\"answer\":\"The document lists reference intervals for non-pregnant persons (and separate ranges for males and non-pregnant pre- or post-menopausal females) and then provides expected serum hCG values by completed weeks of gestation for pregnant females.\"},{\"question\":\"What is the expected serum hCG concentration doubling time in early normal pregnancy?\",\"answer\":\"In the first three weeks of a normal pregnancy, serum hCG approximately doubles every two days. The document provides gestational-day group limits for expected doubling time (e.g., ≤2.2 days for days 9–21, ≤2.6 days for days 21–28, and ≤4.4 days for days 28–36).\"},{\"question\":\"Can serial hCG values alone determine intrauterine pregnancy, miscarriage, or ectopic pregnancy?\",\"answer\":\"No. The document states that serial hCG values should not be used alone. About 21% of ectopic pregnancies can show an hCG rise similar to an intrauterine pregnancy, and 8% can show an hCG fall similar to miscarriage, so results must be combined with clinical judgment, symptoms, and repeat ultrasound as needed.\"}]","Interpretation of Serum Human Chorionic Gonadotropin (hCG) Results in Pregnancy | PDF",1791854796]