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The report extends to animal studies, epidemiological data focusing on low-dose-rate and low-dose effects, and analyses of dose-response shape and curvature. It further reviews biologically motivated mechanistic models to support risk assessment frameworks.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/template/","Template",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/template/presentations/","Presentations",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/template/icrp-publication-xxx-scientific-evidence-relevant-to-the-assessment-of-solid-cancer-radiation-risk-at-low-dose-and-low-dose-rate-final-report/177608/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/icrp-publication-xxx-scientific-evidence-relevant-to-the-assessment-of-solid-cancer-radiation-risk-at-low-dose-and-low-dose-rate-final-report/177608.png","ImageObject",442,249,{"name":42,"@type":43},"Oliver Hayes","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/vnd.openxmlformats-officedocument.wordprocessingml.document","2026-10-21","2026-09-02",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What radiation conditions does this publication address for solid cancer risk assessment?","Question",{"text":63,"@type":64},"It focuses on low dose and low dose rate conditions relevant to the assessment of solid cancer radiation risk.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which historical concepts are defined in the report?",{"text":68,"@type":64},"The report defines LDEF, DREF, and DDREF, and discusses their development through national and international perspectives.",{"name":70,"@type":61,"acceptedAnswer":71},"How is the evidence organized beyond history and concepts?",{"text":72,"@type":64},"The publication reviews cellular radiobiological studies, animal studies, epidemiological evidence (low-dose-rate and low-dose effects), and studies using biologically motivated mechanistic models.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},177608,1791744579,{"code":4,"msg":82,"data":83},"success",[84,88,93,98,103,108,113,118,123],{"id":85,"doc_module":22,"doc_module_name":25,"category_name":29,"show_sort_weight":86,"slug":87},11,90,"presentations",{"id":89,"doc_module":22,"doc_module_name":25,"category_name":90,"show_sort_weight":91,"slug":92},12,"Resumes",80,"resumes",{"id":94,"doc_module":22,"doc_module_name":25,"category_name":95,"show_sort_weight":96,"slug":97},14,"Invoices",70,"invoices",{"id":99,"doc_module":22,"doc_module_name":25,"category_name":100,"show_sort_weight":101,"slug":102},15,"Posters",60,"posters",{"id":104,"doc_module":22,"doc_module_name":25,"category_name":105,"show_sort_weight":106,"slug":107},16,"Social Media",50,"social-media",{"id":109,"doc_module":22,"doc_module_name":25,"category_name":110,"show_sort_weight":111,"slug":112},17,"Forms",40,"forms",{"id":114,"doc_module":22,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},18,"Letters",30,"letters",{"id":119,"doc_module":22,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},21,"Paper Templates",5,"papers-templates",{"id":124,"doc_module":22,"doc_module_name":25,"category_name":125,"show_sort_weight":4,"slug":126},158,"General","general-158",{"code":4,"msg":82,"data":128},{"doc_id":79,"user_id":129,"nickname":42,"user_avatar":130,"doc_module":22,"category_id":85,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":131,"file_id":132,"file_url":133,"file_type":134,"file_size":135,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":136,"language":137,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":138,"faqs":139,"seo_title":140,"seo_description":12,"update_tm":141,"read_time":142},687207020761,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","ICRP ref: 4904-3744-8231\nAnnals of the ICRP\nICRP PUBLICATION XXX\nScientific Evidence Relevant to the Assessment of Solid Cancer Radiation Risk at Low Dose and Low Dose Rate\nEditor-in-Chief\nC.H. CLEMENT\nAssociate Editor\nK. NAKAMURA\nAuthors on behalf of ICRP\nxxx\nPUBLISHED FOR\nThe International Commission on Radiological Protection\nby\n\u0013 INCLUDEPICTURE \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\u0013 INCLUDEPICTURE  \"https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png\" \\* MERGEFORMATINET \u0014\n\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\u0015\nPlease cite this issue as ‘ICRP, 20xx. Scientific evidence relevant to the assessment of solid cancer radiation risk at low dose and low dose rate. ICRP Publication XXX. Ann. ICRP xx(x).’\u000f\nCONTENTS\n\u0013 TOC \\o \"1-2\" \\u \u0014Abstract\t\u0013 PAGEREF _Toc191912770 \\h \u00144\u0015\nMAIN POINTS\t\u0013 PAGEREF _Toc191912771 \\h \u00145\u0015\nEXECUTIVE SUMMARY\t\u0013 PAGEREF _Toc191912772 \\h \u00146\u0015\n1.\tINTRODUCTION\t\u0013 PAGEREF _Toc191912773 \\h \u00149\u0015\n1.1.\tBackground\t\u0013 PAGEREF _Toc191912774 \\h \u00149\u0015\n1.2.\tScope and objective\t\u0013 PAGEREF _Toc191912775 \\h \u001413\u0015\n1.3.\tStructure of this publication\t\u0013 PAGEREF _Toc191912776 \\h \u001414\u0015\n2.\tHISTORICAL DEVELOPMENT\t\u0013 PAGEREF _Toc191912777 \\h \u001416\u0015\n2.1.\tDefinition of LDEF, DREF, and DDREF\t\u0013 PAGEREF _Toc191912778 \\h \u00141","cbCailkMzN3fD949","https://ap.wps.com/l/cbCailkMzN3fD949","docx",345697,129,"English","# Abstract\n# MAIN POINTS\n# EXECUTIVE SUMMARY\n# 1. INTRODUCTION\n## 1.1. Background\n## 1.2. Scope and objective\n## 1.3. Structure of this publication\n# 2. HISTORICAL DEVELOPMENT\n## 2.1. Definition of LDEF, DREF, and DDREF\n## 2.2. Positions of National and International Organisations – Historical Context\n## 2.3. Selected Recent Relevant Publications\n## 2.4. Conclusions\n# 3. CELLULAR RADIOBIOLOGICAL STUDIES\n## 3.1. Identifying mechanisms and cellular endpoints relevant for studying LDEF and DREF\n## 3.2. Consideration of specific endpoints\n## 3.3. Effects of low dose and dose rate – should they be considered together?\n## 3.4. Modulation of responses to radiation\n## 3.5. Conclusion","[{\"question\":\"What radiation conditions does this publication address for solid cancer risk assessment?\",\"answer\":\"It focuses on low dose and low dose rate conditions relevant to the assessment of solid cancer radiation risk.\"},{\"question\":\"Which historical concepts are defined in the report?\",\"answer\":\"The report defines LDEF, DREF, and DDREF, and discusses their development through national and international perspectives.\"},{\"question\":\"How is the evidence organized beyond history and concepts?\",\"answer\":\"The publication reviews cellular radiobiological studies, animal studies, epidemiological evidence (low-dose-rate and low-dose effects), and studies using biologically motivated mechanistic models.\"}]","ICRP Publication XXX - Scientific Evidence Relevant to the Assessment of Solid Cancer Radiation Risk at Low Dose and Low Dose Rate - Final report | DOCX",1788328528,45]