[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-1-en-105":3,"doc-seo-195292-105":53,"doc-detail-195292-en":126},{"code":4,"msg":5,"data":6},0,"success",[7,14,19,24,29,34,39,44,49],{"id":8,"doc_module":9,"doc_module_name":10,"category_name":11,"show_sort_weight":12,"slug":13},11,1,"Template","Presentations",90,"presentations",{"id":15,"doc_module":9,"doc_module_name":10,"category_name":16,"show_sort_weight":17,"slug":18},12,"Resumes",80,"resumes",{"id":20,"doc_module":9,"doc_module_name":10,"category_name":21,"show_sort_weight":22,"slug":23},14,"Invoices",70,"invoices",{"id":25,"doc_module":9,"doc_module_name":10,"category_name":26,"show_sort_weight":27,"slug":28},15,"Posters",60,"posters",{"id":30,"doc_module":9,"doc_module_name":10,"category_name":31,"show_sort_weight":32,"slug":33},16,"Social Media",50,"social-media",{"id":35,"doc_module":9,"doc_module_name":10,"category_name":36,"show_sort_weight":37,"slug":38},17,"Forms",40,"forms",{"id":40,"doc_module":9,"doc_module_name":10,"category_name":41,"show_sort_weight":42,"slug":43},18,"Letters",30,"letters",{"id":45,"doc_module":9,"doc_module_name":10,"category_name":46,"show_sort_weight":47,"slug":48},21,"Paper Templates",5,"papers-templates",{"id":50,"doc_module":9,"doc_module_name":10,"category_name":51,"show_sort_weight":4,"slug":52},158,"General","general-158",{"code":4,"msg":54,"data":55},"ok",{"site_id":56,"language":57,"slug":58,"title":59,"keywords":60,"description":61,"schema_data":62,"social_meta":119,"head_meta":121,"extra_data":123,"updated_unix":125},105,"en","gene-expression-profiling-of-uterine-nk-cells","Gene expression profiling of uterine NK cells","","This study presents a comprehensive gene expression analysis of different uterine Natural Killer (NK) cell subsets, specifically pNK cells (CD56dim and CD56bright) and decidual NK (dNK) cells. The research utilizes flow cytometry and transcriptome analysis, including RNA sequencing, to identify distinct molecular signatures. Key findings reveal significant differences in the expression of various genes across these subsets, categorized into membrane proteins/receptors, chemokines/immunomodulatory and other secreted proteins, and immune effector and apoptosis-related molecules. For instance, dNK cells upregulate genes such as PRF1 and GZMB, indicative of cytotoxic activity, while also showing distinct patterns in other functional categories. The study also characterizes cell surface marker expression, with CD56, CD16, CD9, CD151, CD158b*, NKB1**, KIR2DL4, and CD62L exhibiting differential expression between the various pNK and dNK populations. Hierarchical clustering of gene expression data further supports the distinct molecular profiles, grouping decidual NK cells separately from peripheral NK cells. This detailed molecular characterization provides crucial insights into the functional specialization and heterogeneity of uterine NK cells, vital for understanding their role in reproductive processes and immune surveillance within the uterus.",{"@graph":63,"@context":118},[64,80,101],{"@type":65,"itemListElement":66},"BreadcrumbList",[67,71,74,77],{"item":68,"name":69,"@type":70,"position":9},"https://docshare.wps.com","Home","ListItem",{"item":72,"name":10,"@type":70,"position":73},"https://docshare.wps.com/template/",2,{"item":75,"name":51,"@type":70,"position":76},"https://docshare.wps.com/template/general/",3,{"item":78,"name":59,"@type":70,"position":79},"https://docshare.wps.com/template/gene-expression-profiling-of-uterine-nk-cells/195292/",4,{"url":78,"name":59,"@type":81,"image":82,"author":87,"headline":59,"publisher":90,"fileFormat":93,"inLanguage":57,"description":61,"dateModified":94,"datePublished":95,"encodingFormat":93,"isAccessibleForFree":96,"interactionStatistic":97},"DigitalDocument",{"url":83,"@type":84,"width":85,"height":86},"https://docshare.wps.com/thumbnails/gene-expression-profiling-of-uterine-nk-cells/195292.png","ImageObject",442,249,{"name":88,"@type":89},"Aria","Person",{"url":68,"name":91,"@type":92},"DocShare","Organization","application/pdf","2026-09-25","2026-09-03",true,{"@type":98,"interactionType":99,"userInteractionCount":76},"InteractionCounter",{"@type":100},"ViewAction",{"@type":102,"mainEntity":103},"FAQPage",[104,110,114],{"name":105,"@type":106,"acceptedAnswer":107},"What are the main subsets of uterine NK cells investigated in this study?","Question",{"text":108,"@type":109},"The study investigates peripheral NK (pNK) cells, specifically CD56dim and CD56bright subsets, and decidual NK (dNK) cells found in the uterus.","Answer",{"name":111,"@type":106,"acceptedAnswer":112},"What types of molecules were analyzed for differential gene expression?",{"text":113,"@type":109},"The analysis focused on three main categories: membrane proteins/receptors, chemokines/immunomodulatory and other secreted proteins, and immune effector and apoptosis-related molecules.",{"name":115,"@type":106,"acceptedAnswer":116},"What are some key genes found to be differentially expressed in decidual NK cells?",{"text":117,"@type":109},"Decidual NK cells showed upregulation of genes like PRF1 and GZMB, which are involved in immune effector functions and apoptosis.","https://schema.org",{"og:url":78,"og:type":120,"og:title":59,"og:site_name":91,"og:description":61},"article",{"robots":122,"canonical":78},"index,follow",{"doc_id":124,"site_id":56},195292,1790007114,{"code":4,"msg":5,"data":127},{"doc_id":124,"user_id":128,"nickname":88,"user_avatar":129,"doc_module":9,"category_id":50,"category_name":51,"doc_title":59,"doc_description":61,"doc_content":60,"file_id":130,"file_url":131,"file_type":132,"file_size":133,"view_count":76,"is_deleted":4,"is_public":9,"is_downloadable":9,"audit_status":9,"page_count":15,"language":134,"language_code":57,"site_id":56,"html_lang":57,"table_of_contents":135,"faqs":136,"seo_title":137,"seo_description":61,"update_tm":138,"read_time":79},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","cbCairvX7iPK2HvR","https://ap.wps.com/l/cbCairvX7iPK2HvR","pdf",683056,"English","# Membrane proteins/receptors (dnK, pNKbright, pNKdim)\n# Chemokines, immunomodulatory and other secreted proteins\n# Immune effector and apoptosis-related molecules","[{\"question\":\"What are the main subsets of uterine NK cells investigated in this study?\",\"answer\":\"The study investigates peripheral NK (pNK) cells, specifically CD56dim and CD56bright subsets, and decidual NK (dNK) cells found in the uterus.\"},{\"question\":\"What types of molecules were analyzed for differential gene expression?\",\"answer\":\"The analysis focused on three main categories: membrane proteins/receptors, chemokines/immunomodulatory and other secreted proteins, and immune effector and apoptosis-related molecules.\"},{\"question\":\"What are some key genes found to be differentially expressed in decidual NK cells?\",\"answer\":\"Decidual NK cells showed upregulation of genes like PRF1 and GZMB, which are involved in immune effector functions and apoptosis.\"}]","Gene expression profiling of uterine NK cells | PDF",1788447165]