[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-563733-105":3,"detail-sidebar-cat-1-en-105":80,"doc-detail-563733-en":126},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","estradiol-equivalent-doses-approximate-guidance","Estradiol Equivalent Doses - Approximate Guidance","","Estradiol equivalent doses provide a rough, approximate framework for calculating dose equivalents, noting that accuracy is limited because absorption and metabolism of estradiol vary by individual. Guidance emphasizes using this reference alongside additional hormone treatment documents and highlights considerations when switching doses. Key switching points include preferring transdermal estradiol as first-line due to VTE risk differences, reducing to a lower dose, rechecking estradiol levels and blood pressure per prescribing guidance, then increasing if appropriate. A dose table compares patch, gel, spray, and oral options.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/template/","Template",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/template/forms/","Forms",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/template/estradiol-equivalent-doses-approximate-guidance/563733/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/estradiol-equivalent-doses-approximate-guidance/563733.png","ImageObject",442,249,{"name":42,"@type":43},"Boyslovefans","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-19","2026-10-12",true,{"@type":52,"interactionType":53,"userInteractionCount":26},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"Why are estradiol equivalent doses only approximate?","Question",{"text":62,"@type":63},"Equivalent-dose calculations are not exact because individuals differ in estradiol absorption and metabolism. The document states all listed doses are approximate and meant as a rough outline.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"What should clinicians consider when switching estradiol doses?",{"text":67,"@type":63},"The guidance advises switching with attention to formulation and patient risk: use transdermal estradiol as a first-line option, switch to a lower dose, recheck estradiol levels and blood pressure per prescribing guidance, then increase if appropriate.",{"name":69,"@type":60,"acceptedAnswer":70},"How does the table compare different estradiol delivery forms?",{"text":71,"@type":63},"The table lists dose equivalences across patch strengths (e.g., 25 mcg, 50 mcg, 75 mcg, 100 mcg) and specific gel products, then provides spray and oral estradiol equivalents (e.g., oral estradiol 0.5 mg, 1 mg, 1–2 mg, 2–3 mg, 3–4 mg).","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},563733,1792415197,{"code":4,"msg":81,"data":82},"success",[83,88,93,98,103,108,112,117,122],{"id":84,"doc_module":22,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},11,"Presentations",90,"presentations",{"id":89,"doc_module":22,"doc_module_name":25,"category_name":90,"show_sort_weight":91,"slug":92},12,"Resumes",80,"resumes",{"id":94,"doc_module":22,"doc_module_name":25,"category_name":95,"show_sort_weight":96,"slug":97},14,"Invoices",70,"invoices",{"id":99,"doc_module":22,"doc_module_name":25,"category_name":100,"show_sort_weight":101,"slug":102},15,"Posters",60,"posters",{"id":104,"doc_module":22,"doc_module_name":25,"category_name":105,"show_sort_weight":106,"slug":107},16,"Social Media",50,"social-media",{"id":109,"doc_module":22,"doc_module_name":25,"category_name":29,"show_sort_weight":110,"slug":111},17,40,"forms",{"id":113,"doc_module":22,"doc_module_name":25,"category_name":114,"show_sort_weight":115,"slug":116},18,"Letters",30,"letters",{"id":118,"doc_module":22,"doc_module_name":25,"category_name":119,"show_sort_weight":120,"slug":121},21,"Paper Templates",5,"papers-templates",{"id":123,"doc_module":22,"doc_module_name":25,"category_name":124,"show_sort_weight":4,"slug":125},158,"General","general-158",{"code":4,"msg":81,"data":127},{"doc_id":78,"user_id":128,"nickname":42,"user_avatar":129,"doc_module":22,"category_id":109,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":130,"file_id":131,"file_url":132,"file_type":133,"file_size":134,"view_count":26,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":22,"language":135,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":136,"faqs":137,"seo_title":138,"seo_description":12,"update_tm":139,"read_time":4},1374410101428,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Estradiol Equivalent doses:  \nCalculating equivalent doses of Estradiol is not exact due to differing absorption and metabolism of Estradiol by each individual. All of these doses are approximate and this is a rough outline.  \nThis should be used in conjunction with other information on hormones including the following documents:  \n- Information about hormone regimens  \n- Initiating Feminising Hormone treatment  \nPoints to consider when switching doses of Estradiol:  \n- Transdermal Estradiol should be first line option for patients due to the risk of VTE with oral estradiol  \n- We would advise to switch to a lower dose, recheck levels and blood pressure as per our prescribing guidance then increase if appropriate.  \n\n| Patch | Half a 25 mcg\u003Cbr>patch | 25 mcg patch | 50 mcg patch | 75mcg patch | 100mcg patch |\n| --- | --- | --- | --- | --- | --- |\n| Gel – pump\u003Cbr>(Oestrogel) | ½ pump | 1 pump | 2 pumps | 3 pumps | 4 pumps |\n| Gel – sachet\u003Cbr>(Sandrena) | ½ of 0.5mg\u003Cbr>sachet | 0.5mg sachet | 1mg sachet | 1.5mg sachet | 2mg sachet |\n| Spray (Lenzetto) | - | 1-2 sprays | 2-3 sprays | >3 sprays | >4 sprays |\n| Oral Estradiol | 0.5mg | 1mg | 1-2mg | 2-3mg | 3-4mg |","cbCaiqoK3jFqtd7f","https://ap.wps.com/l/cbCaiqoK3jFqtd7f","pdf",99416,"English","# Estradiol equivalent doses overview\n## Importance of approximation\n## When switching estradiol doses\n### Transdermal as first-line\n### Lower-dose switch and recheck\n# Dose conversion table\n## Patch and gel options\n## Spray and oral estradiol options","[{\"question\":\"Why are estradiol equivalent doses only approximate?\",\"answer\":\"Equivalent-dose calculations are not exact because individuals differ in estradiol absorption and metabolism. The document states all listed doses are approximate and meant as a rough outline.\"},{\"question\":\"What should clinicians consider when switching estradiol doses?\",\"answer\":\"The guidance advises switching with attention to formulation and patient risk: use transdermal estradiol as a first-line option, switch to a lower dose, recheck estradiol levels and blood pressure per prescribing guidance, then increase if appropriate.\"},{\"question\":\"How does the table compare different estradiol delivery forms?\",\"answer\":\"The table lists dose equivalences across patch strengths (e.g., 25 mcg, 50 mcg, 75 mcg, 100 mcg) and specific gel products, then provides spray and oral estradiol equivalents (e.g., oral estradiol 0.5 mg, 1 mg, 1–2 mg, 2–3 mg, 3–4 mg).\"}]","Estradiol Equivalent Doses - Approximate Guidance | PDF",1791837946]