[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-238220-105":3,"detail-sidebar-cat-1-en-105":80,"doc-detail-238220-en":126},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","drug-information-table-arbs-losartan-cozaar-dosage-and-safety","Drug Information Table - ARBs - Losartan (Cozaar) - Dosage and Safety","","Drug information table for angiotensin II receptor blockers (ARBs) focusing on losartan (Cozaar). Summarizes therapeutic uses including hypertension control, stroke prevention (losartan only), diabetic nephropathy indications (losartan and irbesartan), heart failure treatment (valsartan and candesartan), and migraine prevention (candesartan). Provides administration details such as oral-only use, combination with hydrochlorothiazide, food flexibility, and dose reduction for diuretics or liver failure. Includes adverse effects, contraindications, precautions, interactions, and patient instructions for managing angioedema, monitoring CNS effects, blood pressure, pregnancy risk, hyperkalemia, and drug-level changes.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/template/","Template",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/template/general/","General",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/template/drug-information-table-arbs-losartan-cozaar-dosage-and-safety/238220/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/drug-information-table-arbs-losartan-cozaar-dosage-and-safety/238220.png","ImageObject",442,249,{"name":42,"@type":43},"Alex Sinclair","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-09-20","2026-09-11",true,{"@type":52,"interactionType":53,"userInteractionCount":30},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What conditions is losartan (Cozaar) used to treat or prevent?","Question",{"text":62,"@type":63},"Losartan treats hypertension and helps prevent stroke. It is also indicated for diabetic nephropathy, and it may be used in combination with hydrochlorothiazide.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How is losartan administered and what dose considerations apply?",{"text":67,"@type":63},"ARBs are available for oral administration only. Losartan may be taken with or without food, and the beginning dose is decreased for patients taking diuretics or with liver failure.",{"name":69,"@type":60,"acceptedAnswer":70},"What major adverse effects require specific actions?",{"text":71,"@type":63},"Angioedema is a potential risk; treat severe angioedema with IV epinephrine and discontinue any ARB if it occurs. For severe hypotension, monitor blood pressure and manage by expanding volume with IV fluids.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},238220,1789132734,{"code":4,"msg":81,"data":82},"success",[83,88,93,98,103,108,113,118,123],{"id":84,"doc_module":22,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},11,"Presentations",90,"presentations",{"id":89,"doc_module":22,"doc_module_name":25,"category_name":90,"show_sort_weight":91,"slug":92},12,"Resumes",80,"resumes",{"id":94,"doc_module":22,"doc_module_name":25,"category_name":95,"show_sort_weight":96,"slug":97},14,"Invoices",70,"invoices",{"id":99,"doc_module":22,"doc_module_name":25,"category_name":100,"show_sort_weight":101,"slug":102},15,"Posters",60,"posters",{"id":104,"doc_module":22,"doc_module_name":25,"category_name":105,"show_sort_weight":106,"slug":107},16,"Social Media",50,"social-media",{"id":109,"doc_module":22,"doc_module_name":25,"category_name":110,"show_sort_weight":111,"slug":112},17,"Forms",40,"forms",{"id":114,"doc_module":22,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},18,"Letters",30,"letters",{"id":119,"doc_module":22,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},21,"Paper Templates",5,"papers-templates",{"id":124,"doc_module":22,"doc_module_name":25,"category_name":29,"show_sort_weight":4,"slug":125},158,"general-158",{"code":4,"msg":81,"data":127},{"doc_id":78,"user_id":128,"nickname":42,"user_avatar":129,"doc_module":22,"category_id":124,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":130,"file_id":131,"file_url":132,"file_type":133,"file_size":134,"view_count":30,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":22,"language":135,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":136,"faqs":137,"seo_title":138,"seo_description":12,"update_tm":79,"read_time":4},1099523882182,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Drug Information Table ARBs – losartan (Cozaar)  \n\n| Therapeutic Use | Administration |  |\n| --- | --- | --- |\n| • Treats hypertension (all ARBs)\u003Cbr>• Prevents stroke (losartan only)\u003Cbr>• Manages diabetic nephropathy (losartan and irbesartan [Avapro] only)\u003Cbr>• Treats heart failure (valsartan [Diovan] and candesartan [Atacand] only)\u003Cbr>• Prevents migraine headache (candesartan [Atacand] only) | • ARBs are available for oral administration only\u003Cbr>• Losartan is also available in combination with the thiazine diuretic, hydrochlorothiazide (Hyzaar)\u003Cbr>• May be taken with or without food\u003Cbr>• Beginning dose is decreased for patients taking diuretics or with liver failure |  |\n| Side/Adverse Effects | Interventions | Patient Instructions |\n| • Angioedema (occurs less than with ACE inhibitors, but still a potential risk) | • Treat severe angioedema with IV epinephrine\u003Cbr>• Discontinue use of any ARB ifangioedema occurs | • Report minor swelling of mouth,\u003Cbr>throat to provider; call 911 immediately if severe reaction\u003Cbr>occurs |\n| • Headache, insomnia | • Monitor for and report CNS effects | • Report frequent headaches or insomnia to provider |\n| • Severe hypotension may occur with overdose or in volume depletion | • Monitor BP before administering losartan dose\u003Cbr>• Manage severe hypotension by expanding volume using IV fluid therapy | • Report episodes of fainting, dizziness to provider |\n|  |  | • Do not take losartan if pregnant or breast feeding\u003Cbr>• Tell provider if pregnancy is a possibility |\n| Contraindications | Precautions | Interactions |\n| • Pregnancy risk category D for second and third trimesters (fetal damage)\u003Cbr>• Allergy to losartan\u003Cbr>• Children younger than 6 years old\u003Cbr>• Child >6 years who has a very low creatinine clearance | • Concurrent diuretic use\u003Cbr>• Hyperkalemia\u003Cbr>• Liver or renal disorders\u003Cbr>• First trimester of pregnancy | • Antihypertensive drugs increase risk for hypotension\u003Cbr>• Phenobarbital decreases serum levels of losartan |","cbCaifWqB5bmw55Z","https://ap.wps.com/l/cbCaifWqB5bmw55Z","pdf",90225,"English","# Therapeutic Use\n## Administration\n# Side/Adverse Effects\n## Interventions and Patient Instructions\n# Contraindications and Precautions\n## Interactions","[{\"question\":\"What conditions is losartan (Cozaar) used to treat or prevent?\",\"answer\":\"Losartan treats hypertension and helps prevent stroke. It is also indicated for diabetic nephropathy, and it may be used in combination with hydrochlorothiazide.\"},{\"question\":\"How is losartan administered and what dose considerations apply?\",\"answer\":\"ARBs are available for oral administration only. Losartan may be taken with or without food, and the beginning dose is decreased for patients taking diuretics or with liver failure.\"},{\"question\":\"What major adverse effects require specific actions?\",\"answer\":\"Angioedema is a potential risk; treat severe angioedema with IV epinephrine and discontinue any ARB if it occurs. For severe hypotension, monitor blood pressure and manage by expanding volume with IV fluids.\"}]","Drug Information Table - ARBs - Losartan (Cozaar) - Dosage and Safety | PDF"]