[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-1-en-105":3,"doc-seo-162772-105":53,"doc-detail-162772-en":126},{"code":4,"msg":5,"data":6},0,"success",[7,14,19,24,29,34,39,44,49],{"id":8,"doc_module":9,"doc_module_name":10,"category_name":11,"show_sort_weight":12,"slug":13},11,1,"Template","Presentations",90,"presentations",{"id":15,"doc_module":9,"doc_module_name":10,"category_name":16,"show_sort_weight":17,"slug":18},12,"Resumes",80,"resumes",{"id":20,"doc_module":9,"doc_module_name":10,"category_name":21,"show_sort_weight":22,"slug":23},14,"Invoices",70,"invoices",{"id":25,"doc_module":9,"doc_module_name":10,"category_name":26,"show_sort_weight":27,"slug":28},15,"Posters",60,"posters",{"id":30,"doc_module":9,"doc_module_name":10,"category_name":31,"show_sort_weight":32,"slug":33},16,"Social Media",50,"social-media",{"id":35,"doc_module":9,"doc_module_name":10,"category_name":36,"show_sort_weight":37,"slug":38},17,"Forms",40,"forms",{"id":40,"doc_module":9,"doc_module_name":10,"category_name":41,"show_sort_weight":42,"slug":43},18,"Letters",30,"letters",{"id":45,"doc_module":9,"doc_module_name":10,"category_name":46,"show_sort_weight":47,"slug":48},21,"Paper Templates",5,"papers-templates",{"id":50,"doc_module":9,"doc_module_name":10,"category_name":51,"show_sort_weight":4,"slug":52},158,"General","general-158",{"code":4,"msg":54,"data":55},"ok",{"site_id":56,"language":57,"slug":58,"title":59,"keywords":60,"description":61,"schema_data":62,"social_meta":119,"head_meta":121,"extra_data":123,"updated_unix":125},105,"en","covalent-imprinting-of-silica-networks-via-sol-gel-processing-masters-thesis","Covalent Imprinting of Silica Networks via Sol-Gel Processing - Master’s Thesis","","Three covalently imprinted silica networks and three non-imprinted silica networks were synthesized using sol-gel processing. Benzyl thiosulfate served as the template, tetraethyl orthosilicate as the cross-linker, ethanol as the solvent, and ammonium hydroxide as the base catalyst. The template and functional monomer were prepared through multi-step reactions, then used to form the covalently imprinted materials. Template removal relied on sodium borohydride to cleave disulfide bonds, followed by batch rebinding to evaluate selectivity and affinity.",{"@graph":63,"@context":118},[64,80,101],{"@type":65,"itemListElement":66},"BreadcrumbList",[67,71,74,77],{"item":68,"name":69,"@type":70,"position":9},"https://docshare.wps.com","Home","ListItem",{"item":72,"name":10,"@type":70,"position":73},"https://docshare.wps.com/template/",2,{"item":75,"name":46,"@type":70,"position":76},"https://docshare.wps.com/template/paper-templates/",3,{"item":78,"name":59,"@type":70,"position":79},"https://docshare.wps.com/template/covalent-imprinting-of-silica-networks-via-sol-gel-processing-masters-thesis/162772/",4,{"url":78,"name":59,"@type":81,"image":82,"author":87,"headline":59,"publisher":90,"fileFormat":93,"inLanguage":57,"description":61,"dateModified":94,"datePublished":95,"encodingFormat":93,"isAccessibleForFree":96,"interactionStatistic":97},"DigitalDocument",{"url":83,"@type":84,"width":85,"height":86},"https://docshare.wps.com/thumbnails/covalent-imprinting-of-silica-networks-via-sol-gel-processing-masters-thesis/162772.png","ImageObject",442,249,{"name":88,"@type":89},"Jake","Person",{"url":68,"name":91,"@type":92},"DocShare","Organization","application/vnd.openxmlformats-officedocument.wordprocessingml.document","2026-09-24","2026-08-30",true,{"@type":98,"interactionType":99,"userInteractionCount":73},"InteractionCounter",{"@type":100},"ViewAction",{"@type":102,"mainEntity":103},"FAQPage",[104,110,114],{"name":105,"@type":106,"acceptedAnswer":107},"What materials and reagents are used to synthesize the silica networks?","Question",{"text":108,"@type":109},"The synthesis uses benzyl thiosulfate as the template, tetraethyl orthosilicate as the cross-linker, ethanol as the solvent, and ammonium hydroxide as the base catalyst.","Answer",{"name":111,"@type":106,"acceptedAnswer":112},"How is the template removed from the covalently imprinted silica networks?",{"text":113,"@type":109},"Template removal is achieved by cleaving the disulfide bond between the template and the silica network using sodium borohydride as the reducing agent.",{"name":115,"@type":106,"acceptedAnswer":116},"How does the cross-linker content affect selectivity and affinity?",{"text":117,"@type":109},"Batch rebinding shows that increasing cross-linker content increases selectivity toward the template molecule. Covalently imprinted networks also exhibit higher affinity for the template than non-imprinted networks.","https://schema.org",{"og:url":78,"og:type":120,"og:title":59,"og:site_name":91,"og:description":61},"article",{"robots":122,"canonical":78},"index,follow",{"doc_id":124,"site_id":56},162772,1790292678,{"code":4,"msg":5,"data":127},{"doc_id":124,"user_id":128,"nickname":88,"user_avatar":129,"doc_module":9,"category_id":45,"category_name":46,"doc_title":59,"doc_description":61,"doc_content":130,"file_id":131,"file_url":132,"file_type":133,"file_size":134,"view_count":73,"is_deleted":4,"is_public":9,"is_downloadable":9,"audit_status":9,"page_count":135,"language":136,"language_code":57,"site_id":56,"html_lang":57,"table_of_contents":137,"faqs":138,"seo_title":139,"seo_description":61,"update_tm":140,"read_time":141},962084928904,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Covalent Imprinting of Silica Networks\nvia Sol-Gel Processing\nAalborg University\nSection of chemistry\nMaster´s Thesis\nFall 2010\n\u000f\nAbstract\nThree covalently imprinted silica networks and three non-imprinted silica networks were successfully synthesized utilizing the sol-gel process. Benzyl thiosulfate was applied as the template. Tetraethyl orthosilicate was employed as the cross-linker, ethanol was employed as the solvent and ammonium hydroxide was applied as base catalyst.\nThe template was produced from a reaction between benzyl chloride and sodium thiosulfate pentahydrate and purified by extracting with ethanol. 4-tert-buthylbenzyl-thiosulfate was produced from a reaction between 4-tert-buthylbenzyl-chloride and sodium thiosulfate pentahydrate and purified by extracting with ethanol. The functional monomer was synthesized by performing a reaction between benzyl thiosulfate and 3-Mercaptopropyl-Trimethoxysilane. A mixture of the functional monomer and 3-Mercaptopropyl-Trimethoxysilane was obtained as product. This product was utilized in the sol-gel processes of producing the covalently imprinted silica networks.\nSome template was successfully removed from all three covalent imprinted silica networks. The disulfide bond between the template and the silica network was cleaved by applying sodium borohydride as reducing agent. The covalently imprinted silica network with the highest content of cross-linker showed very poor template release and was not analyzed further.\nBatch rebinding experiments revealed that an increase in the content of cross-linker had an increasing effect on the selectivity towards the template molecule. Furthermore, the covalently imprinted silica network showed a higher affinity toward the template than the non-imprinted networks did.\nTitle\nCovalent Imprinting of Silica Networks\nvia Sol-Gel Processing.\nProject Period\nJuly 1st 2010 – November 1st 2010\nAuthor\nErik Michaelsen Nielsen\nSupervisor\nDonghong Yu\nNumber of Copies: 4\nNumber of Pages: 41\nNumber of Appendices: 2\n\u000f\n\u000f\nSynopsis\nTre kovalent prægede silikanetværk og tre ikke prægede silikanetværk var syntetiseret gennem sol-gel processen. Benzylthiosulfate blev anvendt som template. Tetraethyl ortosilicat blev brugt som krydsbinder, ethanol blev brugt som solvent og ammonium hydroxid blev anvendt som basekatalysator.\nTemplatet blev produceret som en reaktion mellem benzylchlorid og natriumthiosulfat pentahydrat og oprenset gennem ekstraktion med ethanol. 4-tert-butylbenzyl-thiosulfat blev produceret gennem en reaktion mellem 4-tert-butylbenzyl-chlorid og natriumthiosulfat pentahydrat og oprenset gennem ekstraktion med ethanol. Den funktionelle monomer blev syntetiseret ved at udføre en reaktion mellem benzylthiosulfate og 3-mercaptopropyltrimethoxysilan.\nEn blanding af den funktionelle monomer og 3-mercaptopropyltrimethoxysilan blev opnået som produkt. Dette produkt blev anvendt i sol-gel processen til produktionen af kovalent prægede silikanetværk.\nTemplatet blev i nogen grad fjernet fra alle tre kovalent prægede silikanetværk. Disulfid bindingen mellem templatet og silikanetværket blev spaltet ved at anvende natriumborhydrid som reduktionsmiddel. Det kovalent prægede silikanetværk med det højeste indhold af krydsbindere udviste meget ringe frigivelse af templatet og blev således ikke analyseret mere.\nBatch gen-bindings studier afslørede at en forhøjelse af krydsbinder indholdet gav en stigende effekt a selektivitet mod template molekylet. Desuden udviste de kovalent prægede silikanetværk en højere affinitet mod templatemolekylet end de ikke prægede silikanetværk.\nTitel\nKovalent Prægning af Silikanetværk\nvia Sol-Gel Processen\nProjektperiode\n1. juli, 2010 – 1. november, 2010\nForfatter\nErik Michaelsen Nielsen\nVejleder\nDonghong Yu\nOplag: 4\nSideantal: 41\nAntal appendiks: 2\n\u000f\n\u000f\nPreface\nThis master´s thesis report is written by Erik Michaelsen Nielsen on the 10th semester at Department of Biotechnology, Chemistry and Environmental Engineering at Aalborg Univer","cbCainRpKd7Qw7zy","https://ap.wps.com/l/cbCainRpKd7Qw7zy","docx",1218270,53,"English","# Introduction\n# Problem Statement\n# SOL-GEL Processing\n## TEOS\n## Hydrolysis and Condensation\n## Acid or Base Catalysis\n## Water Content\n## Solvent\n# Molecular Imprinting\n## Non-Covalent Imprinting\n## Covalent Imprinting\n## Imprinting with disulfide bonds","[{\"question\":\"What materials and reagents are used to synthesize the silica networks?\",\"answer\":\"The synthesis uses benzyl thiosulfate as the template, tetraethyl orthosilicate as the cross-linker, ethanol as the solvent, and ammonium hydroxide as the base catalyst.\"},{\"question\":\"How is the template removed from the covalently imprinted silica networks?\",\"answer\":\"Template removal is achieved by cleaving the disulfide bond between the template and the silica network using sodium borohydride as the reducing agent.\"},{\"question\":\"How does the cross-linker content affect selectivity and affinity?\",\"answer\":\"Batch rebinding shows that increasing cross-linker content increases selectivity toward the template molecule. Covalently imprinted networks also exhibit higher affinity for the template than non-imprinted networks.\"}]","Covalent Imprinting of Silica Networks via Sol-Gel Processing - Master’s Thesis | DOCX",1788130581,19]