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The issue highlights the Iowa site’s research into early drinking predictors, links between anxiety, depression, and alcohol problems, and ongoing work on opioid use predictors, mortality timing, and 1990s blood samples. It also covers COVID-related substance use factors and features profiles of the Iowa team’s roles.",{"@graph":63,"@context":119},[64,80,102],{"@type":65,"itemListElement":66},"BreadcrumbList",[67,71,74,77],{"item":68,"name":69,"@type":70,"position":9},"https://docshare.wps.com","Home","ListItem",{"item":72,"name":10,"@type":70,"position":73},"https://docshare.wps.com/template/",2,{"item":75,"name":41,"@type":70,"position":76},"https://docshare.wps.com/template/letters/",3,{"item":78,"name":59,"@type":70,"position":79},"https://docshare.wps.com/template/coga-newsletter-march-2023/393517/",4,{"url":78,"name":59,"@type":81,"image":82,"author":87,"headline":59,"publisher":90,"fileFormat":93,"inLanguage":57,"description":61,"dateModified":94,"datePublished":95,"encodingFormat":93,"isAccessibleForFree":96,"interactionStatistic":97},"DigitalDocument",{"url":83,"@type":84,"width":85,"height":86},"https://docshare.wps.com/thumbnails/coga-newsletter-march-2023/393517.png","ImageObject",442,249,{"name":88,"@type":89},"Terk","Person",{"url":68,"name":91,"@type":92},"DocShare","Organization","application/pdf","2026-10-16","2026-09-26",true,{"@type":98,"interactionType":99,"userInteractionCount":101},"InteractionCounter",{"@type":100},"ViewAction",6,{"@type":103,"mainEntity":104},"FAQPage",[105,111,115],{"name":106,"@type":107,"acceptedAnswer":108},"What is the COGA study focused on, and how has its scope changed?","Question",{"text":109,"@type":110},"COGA targets the genetics of alcoholism and has updated the newsletter periodically to share research information. As substance use has expanded, COGA extended its scope to genetics of a variety of drugs and how use of one substance may relate to others.","Answer",{"name":112,"@type":107,"acceptedAnswer":113},"What research topics does the Iowa site highlight in this issue?",{"text":114,"@type":110},"The Iowa site discusses predictors of early drinking, connections among anxiety, depression, and alcohol problems, predictors of illegal opioid use, and relationships between alcohol problems and when participants die. It also examines whether older Iowa blood samples relate to health and cognitive outcomes more than 25 years later.",{"name":116,"@type":107,"acceptedAnswer":117},"Who are the people featured in the “Meet the Iowa Team” section?",{"text":118,"@type":110},"The issue includes responses from Sam Kuperman (Principal Investigator), John Kramer (Co-Principal Investigator and Project Manager), Angie Cookman (Principal Interviewer), and Grace Chan (Statistician and Data Manager), describing what they value about their roles.","https://schema.org",{"og:url":78,"og:type":121,"og:title":59,"og:site_name":91,"og:description":61},"article",{"robots":123,"canonical":78},"index,follow",{"doc_id":125,"site_id":56},393517,1791030874,{"code":4,"msg":5,"data":128},{"doc_id":125,"user_id":129,"nickname":88,"user_avatar":130,"doc_module":9,"category_id":40,"category_name":41,"doc_title":59,"doc_description":61,"doc_content":131,"file_id":132,"file_url":133,"file_type":134,"file_size":135,"view_count":101,"is_deleted":4,"is_public":9,"is_downloadable":9,"audit_status":9,"page_count":47,"language":136,"language_code":57,"site_id":56,"html_lang":57,"table_of_contents":137,"faqs":138,"seo_title":139,"seo_description":61,"update_tm":140,"read_time":73},1099525198933,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","COGA NEWSLETTER  \nMarch 2023  \nCollaborative Study on the Genetics of Alcoholism  \nWELCOME!  \nWe are delighted to share with you our new newsletter for the Collaborative Study on the Genetics of Alcoholism (COGA) study, a project that has targeted the genetics of alcoholism for over 30 years. We plan to update this newsletter periodically to share with our research participants (and others) additional information about sites, productivity, and research.  \nWe are grateful to our families who have participated in the COGA study over the years—some include individuals with alcohol problems, while other families do not. Through their dedication we have been able to better understand how alcohol use disorders affect individuals and families across the lifetime. We also have been able to better define risk factors that increase the chance of future alcohol use disorders and to identify factors that decrease this risk. As a wider range of substance use has become more common, we have also extended the scope of COGA to address the genetics of a variety of drugs to better understand how the use of one substance affects the use of others. With the ongoing COVID pandemic, we have tried to better understand its effect on the use of alcohol and other substances and its impact on our research participants.  \nWe look forward to receiving feedback from you regarding the newsletter topics that you find most interesting as well as areas that you hope the newsletter could address in future issues.  \nIN THIS ISSUE:  \n[https://cogastudy.org/](https://cogastudy.org/)  \nSite Spotlight- Iowa  \nLearn more about the Iowa site , what they do , and who they are!  \nWhat kinds of studies and findings has Iowa been involved in?  \nOver the years, Iowa has looked at a number of topics. Dr. Kuperman and Dr. Kramer have background s in child and adolescent problems, so we have explored how they combine with certain genes to predict alcohol misuse. As one example, we have focused on predictors of when young people start to drink. Some of the strongest predictors of early drinking we found were how many of their friends drink and how many family members had alcohol use disorders. Other areas of interest have included the complex connections between anxiety, depression, and alcohol problems.  \nF ro m left to r ight: Betha ny Ma r e n na , Jo h n K ra me r , A ngie Cook ma n , Sa m K u pe r ma n , fo r me r Iowa site me m be rs Shi z ho ng Ha n a nd Xia ng tao Li u .  \nWhat do you hope to achieve in the future? What projects are you working on?  \nTaking the same approach used to predict alcohol initiation, we are starting to identify predictors of illegal opioid use. Another current project is the relationship between alcohol problems and when and why participants die. In addition, we are examining blood samples collected from Iowa participants in the 1990 ' s to see whether these samples are related to health and cognitive problems they have today, more than 25 years later.  \nAt Iowa, we have had a longstanding interest in internalizing problems such as anxiety and depression (  more information about Internalizing characteristics) . We are identifying genes that contribute to these internalizing characteristics. We are also looking at the combined effect of internalizing and externaliz ing disorders on alcohol and drug use, focusing on individuals who have high levels of both characteristics.  \nIn addition, we are targeting factors that are related to increased use of drugs and alcohol during COVID. One possible characteristic is “negative urgency”, the tendency to turn to drugs and alcohol when experiencing negative emotions like anger and anxiety. We are looking to see whether stress from COVID has this effect on substance use in individuals who have high levels of negative urgency.  \nFinally, the Iowa team has found developing this newsletter to be an exciting challenge. We look forward to publishing more issues this year and making improvements based on feedb","cbCaivTQqKwYN9dW","https://ap.wps.com/l/cbCaivTQqKwYN9dW","pdf",1453871,"English","# In This Issue\n## Site Spotlight - Iowa\n## Meet the Iowa Team!","[{\"question\":\"What is the COGA study focused on, and how has its scope changed?\",\"answer\":\"COGA targets the genetics of alcoholism and has updated the newsletter periodically to share research information. As substance use has expanded, COGA extended its scope to genetics of a variety of drugs and how use of one substance may relate to others.\"},{\"question\":\"What research topics does the Iowa site highlight in this issue?\",\"answer\":\"The Iowa site discusses predictors of early drinking, connections among anxiety, depression, and alcohol problems, predictors of illegal opioid use, and relationships between alcohol problems and when participants die. It also examines whether older Iowa blood samples relate to health and cognitive outcomes more than 25 years later.\"},{\"question\":\"Who are the people featured in the “Meet the Iowa Team” section?\",\"answer\":\"The issue includes responses from Sam Kuperman (Principal Investigator), John Kramer (Co-Principal Investigator and Project Manager), Angie Cookman (Principal Interviewer), and Grace Chan (Statistician and Data Manager), describing what they value about their roles.\"}]","COGA Newsletter - March 2023 | PDF",1790389007]