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The template collects principal investigator and project details, requires answers on human and animal research with attached ethics approvals when applicable, and provides an abstract field for up to 250 words. Applicants must submit a document package including an NIH-style biosketch, a combined detailed budget with justification, a research plan with bibliography, and an appendix limited to supplemental proposal or preliminary data. An institutional signature page certifies accuracy, open sharing of final datasets and developed tools, compliance with award policies, and states that indirect costs are capped at 10% of direct costs, subject to the program’s award terms and conditions.","ORPHAN DISEASE CENTER and LOULOU FOUNDATION\nCDKL5 Program of Excellence\nPILOT GRANT PROGRAM\nFull Application\nCover Page\nPI Name:\nPI Title:\nPI Institution:\nProject Title:\nHuman Subjects Research:       \u0003☐\u0004 Yes (Please attach IRB approval letter)         \u0003☐\u0004   No\nAnimal Research:       \u0003☐\u0004 Yes (Please attach IACUC approval letter)         \u0003☐\u0004   No\nAbstract (Up to 250 words):\n\u000f\nChecklist\nATTACH:\n\u0003☐\u0004\tCover Page/Checklist/Institutional Signature Page [PDF]\n\u0003☐\u0004\tNIH-style Biosketch with Other Support of PI and key personnel (5 pages maximum for each PI) [PDF]\nThe PI must include accurate and complete information regarding all other sources of grant support (current and pending), including title, abstract, annual and total amount of grant, inclusive funding period, and percent effort.\n\u0003☐\u0004\tDetailed Budget and Justification [combined into one PDF]\nComplete attached Excel budget sheet. Describe justifications in a Word document. Award will be for one year. Proposed funding period: May 1, 2026 – April 30, 2027.\n\u0003☐\u0004\tResearch Plan (5 pages max) and Bibliography (1 page max) [combined into one PDF]\nInclude the following sections: Lay Summary (to be shared publicly if grant is awarded), Specific Aims, Background and Significance, Preliminary Studies/Data, Research Design and Methods.\nText citations should use a numbered format. Include all author names in the reference list.\n\u0003☐\u0004\tAppendix [combined into one PDF]\nLimited to 5 pages of supplemental information pertaining to proposal or preliminary data only; a maximum of 3 relevant reprints are also acceptable. Include IRB and/or IACUC approval letters if relevant.\n\u000f\nORPHAN DISEASE CENTER\nCDKL5 PROGRAM OF EXCELLENCE PILOT GRANT PROGRAM\nINSTITUTIONAL SIGNATURE PAGE\nCertification and Acceptance:\nWe, the undersigned, certify that the statements contained in the attached grant application are true and complete to the best of our knowledge. We agree to conform to the policies and rules governing this award. We agree to openly share final data sets and observations with the full scientific community, and all reagents and/or research tools developed under support by this mechanism will be made accessible upon request. We understand that the University of Pennsylvania makes no claim to rights on these items or intellectual property other than for those faculty employed by the University of Pennsylvania. We understand that indirect costs are limited to a maximum of 10% of direct costs.\nPrincipal Investigator:\n________________________________\nName (typed)\tSignature\nTitle:\nInstitution:\nDepartment:\nAddress:\nPhone:  \tFax:\nE-mail:\nInstitutional Official:\n________________________________\nName (typed)\tSignature\nTitle:\nInstitution:\nDepartment:\nAddress:\nPhone:  \tFax:\nE-mail:\n\u000f\nORPHAN DISEASE CENTER\nCDKL5 PROGRAM OF EXCELLENCE\nPILOT GRANT PROGRAM\nGrant Program Award Terms\nThe following terms and conditions will apply to the awarded grantee/institution and subcontract institutions.\nThis award is based on the application for the above-referenced project submitted to, and as approved by the University of Pennsylvania and is subject to the terms and conditions below.\nThe Award is contingent upon the availability of funds and is subject to the Terms and Conditions herein, which may be revised from time to time.  By accepting an Award, the Principal Investigator and the Grantee Institution agree to be bound by the Terms and Conditions.\nFunding for this Award is provided by the generous contribution of the Loulou Foundation (the “LLF”).  LLF and ODC have partnered in establishing a Program of Excellence (the “POE”) in CDLK5 research within ODC with the goal of developing effective treatments for patients with a deficiency of CDKL5.\nPAYMENT\nFunds will be issued through cost reimbursement mechanism executed by purchase order from the University of Pennsylvania.  We have been advised by our Office of Research Services that due to the nature of this award, unless your institution objects, we will be able to forego the instit","cbCaibet9K1XlHJC","https://ap.wps.com/l/cbCaibet9K1XlHJC","docx",137436,8,"English","en",105,"# Cover Page\n## Human Subjects Research / Animal Research\n## Abstract and Checklist\n# Institutional Signature Page\n## Certification and Acceptance\n## Principal Investigator Information\n## Institutional Official Information\n# Grant Program Award Terms\n## Payment\n## Terms and Conditions","[{\"question\":\"What documents are required in the full application package?\",\"answer\":\"The checklist requires a cover page/checklist/institutional signature page PDF, an NIH-style biosketch with other support (PDF), a detailed budget and justification combined into one PDF, a combined research plan and bibliography PDF, and an appendix combined into one PDF.\"},{\"question\":\"When are IRB and IACUC approval letters needed?\",\"answer\":\"Human subjects research requires an IRB approval letter if checked as Yes. 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