[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-572167-105":3,"detail-sidebar-cat-1-en-105":80,"doc-detail-572167-en":126},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","bnp-fact-sheet-ntprobnp-assay-guidance","BNP Fact Sheet - NTproBNP assay guidance","","BNP fact sheet outlining how the NTproBNP assay supports the BNSSG suspected heart failure pathway. Explains what BNP is, why elevated levels relate to heart failure, and when testing is recommended under NICE CG108. Lists key clinical situations where BNP/NTproBNP testing may be inappropriate and highlights factors that can raise or lower results. Provides sampling and request workflow and interprets results using age/sex cut-offs with escalation to urgent echocardiography after previous MI.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/template/","Template",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/template/general/","General",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/template/bnp-fact-sheet-ntprobnp-assay-guidance/572167/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/bnp-fact-sheet-ntprobnp-assay-guidance/572167.png","ImageObject",442,249,{"name":42,"@type":43},"Ezra","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-20","2026-10-13",true,{"@type":52,"interactionType":53,"userInteractionCount":26},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What does the NTproBNP (BNP) test assess in suspected heart failure?","Question",{"text":62,"@type":63},"BNP is a hormone released when the heart ventricles are stretched. In heart failure, BNP/NTproBNP levels are raised and increase with NYHA classification, while a normal result generally rules out heart failure.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"When should NTproBNP be requested, and when is testing not indicated?",{"text":67,"@type":63},"NICE CG108 recommends measuring NTproBNP in suspected heart failure. Testing may not be indicated when there is a previous MI, confirmed heart failure, bradycardia or tachycardia, atrial fibrillation, or significant ECG abnormality.",{"name":69,"@type":60,"acceptedAnswer":70},"How should BNP results be interpreted and what is the recommended next step?",{"text":71,"@type":63},"Use the BNSSG pathway cut-offs by age and sex to determine whether heart failure is unlikely. If there is a previous MI, refer urgently for echocardiography and specialist opinion; most referrals go to the Community Heart Failure service.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},572167,1792524726,{"code":4,"msg":81,"data":82},"success",[83,88,93,98,103,108,113,118,123],{"id":84,"doc_module":22,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},11,"Presentations",90,"presentations",{"id":89,"doc_module":22,"doc_module_name":25,"category_name":90,"show_sort_weight":91,"slug":92},12,"Resumes",80,"resumes",{"id":94,"doc_module":22,"doc_module_name":25,"category_name":95,"show_sort_weight":96,"slug":97},14,"Invoices",70,"invoices",{"id":99,"doc_module":22,"doc_module_name":25,"category_name":100,"show_sort_weight":101,"slug":102},15,"Posters",60,"posters",{"id":104,"doc_module":22,"doc_module_name":25,"category_name":105,"show_sort_weight":106,"slug":107},16,"Social Media",50,"social-media",{"id":109,"doc_module":22,"doc_module_name":25,"category_name":110,"show_sort_weight":111,"slug":112},17,"Forms",40,"forms",{"id":114,"doc_module":22,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},18,"Letters",30,"letters",{"id":119,"doc_module":22,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},21,"Paper Templates",5,"papers-templates",{"id":124,"doc_module":22,"doc_module_name":25,"category_name":29,"show_sort_weight":4,"slug":125},158,"general-158",{"code":4,"msg":81,"data":127},{"doc_id":78,"user_id":128,"nickname":42,"user_avatar":129,"doc_module":22,"category_id":124,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":130,"file_id":131,"file_url":132,"file_type":133,"file_size":134,"view_count":26,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":26,"language":135,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":136,"faqs":137,"seo_title":138,"seo_description":12,"update_tm":139,"read_time":22},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","| BLOOD SCIENCES\u003Cbr>DEPARTMENT OF CLINICAL BIOCHEMISTRY\u003Cbr>Title of Document: BNP Fact Sheet\u003Cbr>Q Pulse Reference No: BS/CB/DCB/GEN/10\u003Cbr>Authoriser: Peter Beresford | \u003Cbr>Version NO: 1 |\n| --- | --- |\n\nBNP fact sheet  \nThe BNP (NTproBNP) assay has now been introduced at North Bristol NHS Trust to support the BNSSG Suspected Heart Failure Pathway. The following will help you understand the test and when and how to request appropriately.  \nWhat is NTproBNP  \nBrain Natriuretic Peptide (BNP) is a hormone released by the heart when the ventricles are stretched e.g. by fluid overload. The hormone then causes fluid and sodium loss in the urine and mild vasodilation. In heart failure BNP levels are raised, and increase in level according to New York Heart Association classification. If BNP is normal it generally rules out heart failure.(Negative Predictive Value 97%)  \nWhen should I request a BNP test?  \nThe NICE guideline CG108 recommends that NTproBNP is measured in patients with suspected heart failure. BNP testing will not be indicated however when there is:  \nA previous history of MI  \nA confirmed diagnosis of heart failure Bradycardia or tachycardia (\u003C60 or >100bpm) Atrial fibrillation  \nSignificant abnormality on ECG  \nNote: A history of previous MI and symptoms suggestive of heart failure should prompt urgent referral for Echo without delay.  \nIs there anything else that can affect BNP levels?  \nLeft ventricular hypertrophy, right ventricular overload, ischaemia, tachycardia, hypoxaemia, PE, sepsis, COPD, diabetes, liver cirrhosis, age >70 and eGFR \u003C60 ml/min can all increase BNP.  \nObesity, diuretics, ACE inhibitors, beta blockers, angiotensin receptor antagonists and aldosterone antagonists can lead to falsely low levels although it is felt unlikely to impact on screening but should be factored into clinical judgement when interpreting test results.  \nHow do I do the test?  \nNT proBNP is analysed by Clinical Biochemistry at Southmead Hospital. The sample should be collected into a gold top SST tube and sent to the laboratory on the day of collection. Requests should be made electronically via the ICE system where available or by paper request.  \nWhat to do with the results  \nThe BNSSG Suspected Heart Failure pathway recommends the cut-offs and care pathway below. Referral in the majority of cases will be to the Community Heart Failure service.  \nPage 1 of 2  \n\n| BLOOD SCIENCES\u003Cbr>DEPARTMENT OF CLINICAL BIOCHEMISTRY\u003Cbr>Title of Document: BNP Fact Sheet\u003Cbr>Q Pulse Reference No: BS/CB/DCB/GEN/10\u003Cbr>Authoriser: Peter Beresford | \u003Cbr>Version NO: 1 |\n| --- | --- |\n\nHeart failure is unlikely if the NTproBNP level is:  \n\n| Men under 70yr Women under 70yr All 70yr or over | \u003C100pg/ml\u003Cbr>\u003C150pg/ml\u003Cbr>\u003C300pg/ml |\n| --- | --- |\n\nPrevious MI  \nRefer to Echo and specialist opinion URGENTLY  \nNTproBNP result  \nPage 2 of 2","cbCaicdetY6e4OWO","https://ap.wps.com/l/cbCaicdetY6e4OWO","pdf",28283,"English","# BNP fact sheet\n## What is NTproBNP\n## When should I request a BNP test\n## Factors affecting BNP levels\n## How do I do the test\n## What to do with the results","[{\"question\":\"What does the NTproBNP (BNP) test assess in suspected heart failure?\",\"answer\":\"BNP is a hormone released when the heart ventricles are stretched. In heart failure, BNP/NTproBNP levels are raised and increase with NYHA classification, while a normal result generally rules out heart failure.\"},{\"question\":\"When should NTproBNP be requested, and when is testing not indicated?\",\"answer\":\"NICE CG108 recommends measuring NTproBNP in suspected heart failure. Testing may not be indicated when there is a previous MI, confirmed heart failure, bradycardia or tachycardia, atrial fibrillation, or significant ECG abnormality.\"},{\"question\":\"How should BNP results be interpreted and what is the recommended next step?\",\"answer\":\"Use the BNSSG pathway cut-offs by age and sex to determine whether heart failure is unlikely. If there is a previous MI, refer urgently for echocardiography and specialist opinion; most referrals go to the Community Heart Failure service.\"}]","BNP Fact Sheet - NTproBNP assay guidance | PDF",1791925895]