[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-1-en-105":3,"doc-seo-563820-105":53,"doc-detail-563820-en":126},{"code":4,"msg":5,"data":6},0,"success",[7,14,19,24,29,34,39,44,49],{"id":8,"doc_module":9,"doc_module_name":10,"category_name":11,"show_sort_weight":12,"slug":13},11,1,"Template","Presentations",90,"presentations",{"id":15,"doc_module":9,"doc_module_name":10,"category_name":16,"show_sort_weight":17,"slug":18},12,"Resumes",80,"resumes",{"id":20,"doc_module":9,"doc_module_name":10,"category_name":21,"show_sort_weight":22,"slug":23},14,"Invoices",70,"invoices",{"id":25,"doc_module":9,"doc_module_name":10,"category_name":26,"show_sort_weight":27,"slug":28},15,"Posters",60,"posters",{"id":30,"doc_module":9,"doc_module_name":10,"category_name":31,"show_sort_weight":32,"slug":33},16,"Social Media",50,"social-media",{"id":35,"doc_module":9,"doc_module_name":10,"category_name":36,"show_sort_weight":37,"slug":38},17,"Forms",40,"forms",{"id":40,"doc_module":9,"doc_module_name":10,"category_name":41,"show_sort_weight":42,"slug":43},18,"Letters",30,"letters",{"id":45,"doc_module":9,"doc_module_name":10,"category_name":46,"show_sort_weight":47,"slug":48},21,"Paper Templates",5,"papers-templates",{"id":50,"doc_module":9,"doc_module_name":10,"category_name":51,"show_sort_weight":4,"slug":52},158,"General","general-158",{"code":4,"msg":54,"data":55},"ok",{"site_id":56,"language":57,"slug":58,"title":59,"keywords":60,"description":61,"schema_data":62,"social_meta":119,"head_meta":121,"extra_data":123,"updated_unix":125},105,"en","ascia-skin-prick-testing-guide-for-the-diagnosis-of-allergic-disease-2025","ASCIA Skin Prick Testing Guide for the Diagnosis of Allergic Disease - 2025","","ASCIA Skin Prick Testing Guide for the Diagnosis of Allergic Disease provides clinical guidance for medical practitioners and nurses in Australia and New Zealand on the application, method, and interpretation of allergy skin prick tests. It introduces the role of skin prick testing (SPT) compared with intradermal testing (IDT) and other approaches, outlines pre-test considerations and indications, and describes key factors affecting test value such as allergen relevance, mast cell status, and interpretation within positive and negative controls, emphasizing safety and minimal systemic risk.",{"@graph":63,"@context":118},[64,80,101],{"@type":65,"itemListElement":66},"BreadcrumbList",[67,71,74,77],{"item":68,"name":69,"@type":70,"position":9},"https://docshare.wps.com","Home","ListItem",{"item":72,"name":10,"@type":70,"position":73},"https://docshare.wps.com/template/",2,{"item":75,"name":51,"@type":70,"position":76},"https://docshare.wps.com/template/general/",3,{"item":78,"name":59,"@type":70,"position":79},"https://docshare.wps.com/template/ascia-skin-prick-testing-guide-for-the-diagnosis-of-allergic-disease-2025/563820/",4,{"url":78,"name":59,"@type":81,"image":82,"author":87,"headline":59,"publisher":90,"fileFormat":93,"inLanguage":57,"description":61,"dateModified":94,"datePublished":95,"encodingFormat":93,"isAccessibleForFree":96,"interactionStatistic":97},"DigitalDocument",{"url":83,"@type":84,"width":85,"height":86},"https://docshare.wps.com/thumbnails/ascia-skin-prick-testing-guide-for-the-diagnosis-of-allergic-disease-2025/563820.png","ImageObject",442,249,{"name":88,"@type":89},"Kurz","Person",{"url":68,"name":91,"@type":92},"DocShare","Organization","application/pdf","2026-10-25","2026-10-12",true,{"@type":98,"interactionType":99,"userInteractionCount":47},"InteractionCounter",{"@type":100},"ViewAction",{"@type":102,"mainEntity":103},"FAQPage",[104,110,114],{"name":105,"@type":106,"acceptedAnswer":107},"What is the purpose of skin prick testing (SPT) in allergy diagnosis?","Question",{"text":108,"@type":109},"SPT is the primary skin testing mode for immediate IgE-mediated allergy. It provides information about specific IgE to protein and peptide allergens through a wheal-and-flare reaction.","Answer",{"name":111,"@type":106,"acceptedAnswer":112},"How does intradermal testing (IDT) differ from SPT in terms of use and risk?",{"text":113,"@type":109},"IDT has more specialized applications and generally a higher risk of adverse reactions, including anaphylaxis. It is typically restricted to hospital or specialist settings and is not indicated for routine food allergy.",{"name":115,"@type":106,"acceptedAnswer":116},"Which patients are considered appropriate for SPT based on indications in the guide?",{"text":117,"@type":109},"The guide lists conditions such as rhinitis/rhinoconjunctivitis/rhinosinusitis/allergic conjunctivitis, asthma, atopic dermatitis, and suspected latex allergy as indications. It also specifies scenarios where SPT is not routinely indicated, such as non-specific rashes without allergic/atopic characteristics.","https://schema.org",{"og:url":78,"og:type":120,"og:title":59,"og:site_name":91,"og:description":61},"article",{"robots":122,"canonical":78},"index,follow",{"doc_id":124,"site_id":56},563820,1792524738,{"code":4,"msg":5,"data":127},{"doc_id":124,"user_id":128,"nickname":88,"user_avatar":129,"doc_module":9,"category_id":50,"category_name":51,"doc_title":59,"doc_description":61,"doc_content":130,"file_id":131,"file_url":132,"file_type":133,"file_size":134,"view_count":47,"is_deleted":4,"is_public":9,"is_downloadable":9,"audit_status":9,"page_count":135,"language":136,"language_code":57,"site_id":56,"html_lang":57,"table_of_contents":137,"faqs":138,"seo_title":139,"seo_description":61,"update_tm":140,"read_time":141},2336478945635,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Skin Prick Testing Guide for the Diagnosis of Allergic Disease  \nThis document has been developed by ASCIA, the peak professional body of clinical immunology/allergy specialists in Australia and New Zealand. ASCIA information is based on published literature and expert review, is not influenced by commercial organisations and is not intended to replace medical advice. For patient or carer support contact Allergy & Anaphylaxis Australia or Allergy New Zealand.  \nThis Guide is intended for medical practitioners and nurses in Australia and New Zealand, and outlines the application, method and interpretation of allergy skin prick tests.  \nContents Page  \nIntroduction 2  \nPre-Test Considerations 3  \nMethods 8  \nSkin Prick Test Procedure 12  \nSkin Prick Test Reporting 15  \nInterpretation of Skin Prick Test Results 16  \nPersonnel 19  \nSafety and Risks 21  \nAppendix A: Standards for Skin Prick Testing 23  \nAppendix B: Medications-Antihistamines or with Antihistamine Activity 25  \nIntroduction  \nThere are three types of skin testing used in allergy diagnosis:  \n• Skin prick testing (SPT) is the primary mode of skin testing for immediate IgE-mediated allergy. It is widely practiced, carries very low risk of serious side effects, and provides high quality information when performed optimally and interpreted correctly. It is also called prick skin testing or PST.  \n• Intradermal testing (IDT) is relevant to both immediate IgE-mediated allergy and delayed-type hypersensitivity. When used in the diagnosis of immediate allergy, it carries a higher risk of adverse reactions and requires high levels of technical and interpretive expertise.  \n• Patch testing is relevant to contact hypersensitivity and some other forms of delayed-type hypersensitivity. It is conducted mainly by dermatologists and some immunologists. It is not relevant to immediate or IgE-mediated allergy and will not be discussed.  \nScratch testing is not endorsed and should not be performed.  \nSPT provides information about the presence of specific IgE to protein and peptide antigens (allergens) .  \nSmall amounts of allergen are introduced into the epidermis and non-vascular superficial dermis and interact with specific IgE bound to cutaneous mast cells. Histamine and other mediators are released, leading to a visible wheal-and-flare reaction peaking after about 15 minutes.  \nThe value of this test depends on many steps, including:  \n• The relevance of the test allergen to the condition under investigation.  \n• The correct introduction of a sufficient amount of allergen in its native (allergenic) form.  \n• The functional status of cutaneous mast cells.  \n• The interpretation of the reaction in the context of positive and negative controls.  \nSPT has good sensitivity and specificity for the presence of allergen-specific IgE, and in some cases is more sensitive than in-vitro testing for specific IgE in serum (Wood, Phipatanakul, Hamilton, Eggleston, 1999; van der Zee, de Groot, van Swieten, Jansen, & Aalberse, 1988) . The discomfort is small, and the risk of systemic reactions is minimal although not negligible.  \nThe integration of SPT results, knowledge of the biology of the various allergens and the exposure of the patient, and the nature and timing of the symptoms enable the construction of a diagnosis, and an appropriate management plan for the patient.  \nIDT has more specialised applications such as testing for IgE-mediated drug allergy, particularly penicillin, and venom allergy. It carries a higher risk of anaphylaxis and is generally restricted to a hospital or specialist setting.  \nPre-test considerations  \n\n| Indications for allergy SPT | SPT not routinely indicated in the investigation |\n| --- | --- |\n| Rhinitis/rhinoconjunctivitis/rhinosinusitis/allergic conjunctivitis. | Nonspecific rash without allergic/atopic\u003Cbr>characteristics. |\n| Asthma | Chronic urticaria in the absence of allergic features on history. |\n| Atopic dermatitis | Food intolerance without allergic ","cbCaiuFY62XSg1gi","https://ap.wps.com/l/cbCaiuFY62XSg1gi","pdf",386353,26,"English","# Introduction\n# Pre-Test Considerations\n# Methods\n# Skin Prick Test Procedure\n# Skin Prick Test Reporting\n# Interpretation of Skin Prick Test Results\n# Personnel\n# Safety and Risks\n# Appendix A: Standards for Skin Prick Testing\n# Appendix B: Medications—Antihistamines or with Antihistamine Activity","[{\"question\":\"What is the purpose of skin prick testing (SPT) in allergy diagnosis?\",\"answer\":\"SPT is the primary skin testing mode for immediate IgE-mediated allergy. It provides information about specific IgE to protein and peptide allergens through a wheal-and-flare reaction.\"},{\"question\":\"How does intradermal testing (IDT) differ from SPT in terms of use and risk?\",\"answer\":\"IDT has more specialized applications and generally a higher risk of adverse reactions, including anaphylaxis. It is typically restricted to hospital or specialist settings and is not indicated for routine food allergy.\"},{\"question\":\"Which patients are considered appropriate for SPT based on indications in the guide?\",\"answer\":\"The guide lists conditions such as rhinitis/rhinoconjunctivitis/rhinosinusitis/allergic conjunctivitis, asthma, atopic dermatitis, and suspected latex allergy as indications. It also specifies scenarios where SPT is not routinely indicated, such as non-specific rashes without allergic/atopic characteristics.\"}]","ASCIA Skin Prick Testing Guide for the Diagnosis of Allergic Disease - 2025 | PDF",1791838725,9]