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This longitudinal observational study used clinical weight and height data from birth to 16 years to derive smoothed BMI-for-age percentile curves and examine how BMI relates to its components, weight and 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average-stature peers?",{"text":72,"@type":64},"BMI in children with achondroplasia was higher at birth, showed a lack of a steep increase in infancy, then reached a later nadir between ages 1 and 2, and remained substantially higher through 16 years in both sexes.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},563463,1792097048,{"code":4,"msg":82,"data":83},"success",[84,89,94,99,104,109,114,119,124],{"id":85,"doc_module":22,"doc_module_name":25,"category_name":86,"show_sort_weight":87,"slug":88},11,"Presentations",90,"presentations",{"id":90,"doc_module":22,"doc_module_name":25,"category_name":91,"show_sort_weight":92,"slug":93},12,"Resumes",80,"resumes",{"id":95,"doc_module":22,"doc_module_name":25,"category_name":96,"show_sort_weight":97,"slug":98},14,"Invoices",70,"invoices",{"id":100,"doc_module":22,"doc_module_name":25,"category_name":101,"show_sort_weight":102,"slug":103},15,"Posters",60,"posters",{"id":105,"doc_module":22,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},16,"Social 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Achondroplasia is the most common short stature skeletal dysplasia, with an estimated worldwide prevalence of 250 000. Body mass index (BMI)–for-age references are required for weight management guidance for children with achondroplasia, whose body proportions are unlike those of the average stature population.  \nObjective: This study used weight and height data in a clinical setting to derive smoothed BMI-for-age percentile curves for children with achondroplasia and explored the relation of BMI with its components, weight and height.  \nDesign: This was a longitudinal observational study of anthropometric measures of children with achondroplasia from birth through 16 y of age.  \nResults: The analysis included 1807 BMI data points from 280 children (155 boys, 125 girls) with achondroplasia. As compared with the BMI of peers of average stature, the BMI in children with achondroplasia is higher atbirth, lacksa steep increase in infancy anda later nadir between 1 and 2 y of age, and remains substantially higher through16yofagein both sexes. Patterns ofchange in height and weight in children with achondroplasia are unique in that thereis no overlap in the height distribution after 6 mo of age and no spike in height velocity during infancy or puberty—the 2 periods of greatest linear growth in individuals of average stature.  \nConclusions: Sex-and age-specific BMI curves are available forchildren with achondroplasia (birth to 16 y of age) for health surveillance and future research to determine associations with health outcomes (eg, cardiovascular disease, diabetes, and indication for and outcome of surgery) . Am J Clin Nutr 2008;88:364–71 .  \nINTRODUCTION  \nAchondroplasia is the most common short stature-skeletal dysplasia, occurring in 􀀁1 of 20 000 births (1–4) . Sporadic mutations in fibroblast growth factor receptor 3 (FGFR3) cause 􀀂 80%ofachondroplasia cases, with98%ofall cases attributable to one mutation (G1138A) . Clinical features of this metaphyseal dysplasia include rhizomelia, macrocephaly, frontal bossing, midface hypoplasia, lumbar lordosis and stenosis, and a small foramen magnum (5) . Acceptable terms to describe these patients are Little People (LPs), short stature, or dwarf.  \nExcess weight has severe consequences for the health and well-being of all people, but can especially exacerbate common medical problems for achondroplastic patients, including obstructive sleep apnea, genu varus, spinal stenosis, and lordosis.  \nData from a recent 40-y morbidity and mortality study show that cardiovascular disease–related deaths in achondroplasia are higher than expected compared with age-and sex-matched individuals of average stature, which suggests an influence ofcentral adiposity (6) .  \nBecause thereis a recognized problem in this population, thereis a need to better evaluate appropriate body mass starting in childhood (7, 8) . Weight-for-height curves published in 1996 were the first effort to facilitate simultaneous assessment of weight and height in the clinical setting (7) . We recently published age- and sex-specific weight curves for children with achondroplasia (9), which were comparable with those available for children of average stature and intended to complement ageand sex-specific height curves in longtime clinical use (10) .  \nAverage-stature pediatric BMI-for-age curves have existed for several years, with BMI values beyond the 95th percentile indicating overweight (11) . Current recommendations of the American Academy of Pediatrics to monitor body mass include BMI calculation at all routine well-child health visits and throughout the school years (12) . Because of the unique body proportions in persons with achondroplasia, however, averagestature BMI norms are inappropriate for","cbCaijIZrgzyYguR","https://ap.wps.com/l/cbCaijIZrgzyYguR","pdf",1875946,8,"English","# Abstract\n# Introduction\n# Subjects and Methods","[{\"question\":\"Why are BMI-for-age references needed for children with achondroplasia?\",\"answer\":\"Because achondroplasia children have body proportions unlike average-stature populations, making standard BMI norms inappropriate for weight management guidance.\"},{\"question\":\"How was the BMI-for-age curve developed in the study?\",\"answer\":\"The study used weight and height data collected longitudinally in a clinical setting to derive smoothed BMI-for-age percentile curves from birth through 16 years.\"},{\"question\":\"What did the results show about BMI patterns compared with average-stature peers?\",\"answer\":\"BMI in children with achondroplasia was higher at birth, showed a lack of a steep increase in infancy, then reached a later nadir between ages 1 and 2, and remained substantially higher through 16 years in both sexes.\"}]","Age-appropriate body mass index in children with achondroplasia - BMI interpretation in relation to indexes of height 1–3 | PDF",1791835841]