[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-1-en-105":3,"doc-seo-571127-105":53,"doc-detail-571127-en":126},{"code":4,"msg":5,"data":6},0,"success",[7,14,19,24,29,34,39,44,49],{"id":8,"doc_module":9,"doc_module_name":10,"category_name":11,"show_sort_weight":12,"slug":13},11,1,"Template","Presentations",90,"presentations",{"id":15,"doc_module":9,"doc_module_name":10,"category_name":16,"show_sort_weight":17,"slug":18},12,"Resumes",80,"resumes",{"id":20,"doc_module":9,"doc_module_name":10,"category_name":21,"show_sort_weight":22,"slug":23},14,"Invoices",70,"invoices",{"id":25,"doc_module":9,"doc_module_name":10,"category_name":26,"show_sort_weight":27,"slug":28},15,"Posters",60,"posters",{"id":30,"doc_module":9,"doc_module_name":10,"category_name":31,"show_sort_weight":32,"slug":33},16,"Social Media",50,"social-media",{"id":35,"doc_module":9,"doc_module_name":10,"category_name":36,"show_sort_weight":37,"slug":38},17,"Forms",40,"forms",{"id":40,"doc_module":9,"doc_module_name":10,"category_name":41,"show_sort_weight":42,"slug":43},18,"Letters",30,"letters",{"id":45,"doc_module":9,"doc_module_name":10,"category_name":46,"show_sort_weight":47,"slug":48},21,"Paper Templates",5,"papers-templates",{"id":50,"doc_module":9,"doc_module_name":10,"category_name":51,"show_sort_weight":4,"slug":52},158,"General","general-158",{"code":4,"msg":54,"data":55},"ok",{"site_id":56,"language":57,"slug":58,"title":59,"keywords":60,"description":61,"schema_data":62,"social_meta":119,"head_meta":121,"extra_data":123,"updated_unix":125},105,"en","a-randomized-placebo-controlled-trial-of-nicotinamide-riboside-and-pterostilbene-supplementation-in-experimental-muscle-injury-in-elderly-individuals","A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals","","During aging, the functional decline of muscle stem cells (MuSCs) can reduce skeletal muscle repair and regenerative capacity. This randomized placebo-controlled trial tested whether supplementing elderly participants with nicotinamide riboside plus pterostilbene (NRPT) enhances MuSC recruitment and improves regeneration after electrically induced eccentric muscle injury. Thirty-two participants received NRPT or matched placebo, with biopsies taken pre-injury and after injury through 30 days. NRPT did not affect MuSC content, proliferation, cell size, histological markers, or functional recovery, though supplementation was well tolerated.",{"@graph":63,"@context":118},[64,80,101],{"@type":65,"itemListElement":66},"BreadcrumbList",[67,71,74,77],{"item":68,"name":69,"@type":70,"position":9},"https://docshare.wps.com","Home","ListItem",{"item":72,"name":10,"@type":70,"position":73},"https://docshare.wps.com/template/",2,{"item":75,"name":51,"@type":70,"position":76},"https://docshare.wps.com/template/general/",3,{"item":78,"name":59,"@type":70,"position":79},"https://docshare.wps.com/template/a-randomized-placebo-controlled-trial-of-nicotinamide-riboside-and-pterostilbene-supplementation-in-experimental-muscle-injury-in-elderly-individuals/571127/",4,{"url":78,"name":59,"@type":81,"image":82,"author":87,"headline":59,"publisher":90,"fileFormat":93,"inLanguage":57,"description":61,"dateModified":94,"datePublished":95,"encodingFormat":93,"isAccessibleForFree":96,"interactionStatistic":97},"DigitalDocument",{"url":83,"@type":84,"width":85,"height":86},"https://docshare.wps.com/thumbnails/a-randomized-placebo-controlled-trial-of-nicotinamide-riboside-and-pterostilbene-supplementation-in-experimental-muscle-injury-in-elderly-individuals/571127.png","ImageObject",442,249,{"name":88,"@type":89},"Sarah ","Person",{"url":68,"name":91,"@type":92},"DocShare","Organization","application/pdf","2026-10-24","2026-10-13",true,{"@type":98,"interactionType":99,"userInteractionCount":79},"InteractionCounter",{"@type":100},"ViewAction",{"@type":102,"mainEntity":103},"FAQPage",[104,110,114],{"name":105,"@type":106,"acceptedAnswer":107},"What was the main goal of the NRPT supplementation trial?","Question",{"text":108,"@type":109},"To determine whether nicotinamide riboside and pterostilbene supplementation (NRPT) promotes skeletal muscle regeneration after experimental injury in elderly individuals, by improving MuSC recruitment.","Answer",{"name":111,"@type":106,"acceptedAnswer":112},"How was the study designed and how many participants were included?",{"text":113,"@type":109},"Thirty-two elderly individuals (55–80 years) were randomized to daily NRPT (1,000 mg NR and 200 mg PT) or matched placebo, followed by electrically induced eccentric muscle injury.",{"name":115,"@type":106,"acceptedAnswer":116},"Did NRPT improve muscle recovery after injury?",{"text":117,"@type":109},"No. NRPT did not affect MuSC content, proliferation, cell size, histological measures (muscle fiber area, central nuclei, embryonic myosin heavy chain), or other indicators of muscle recovery.","https://schema.org",{"og:url":78,"og:type":120,"og:title":59,"og:site_name":91,"og:description":61},"article",{"robots":122,"canonical":78},"index,follow",{"doc_id":124,"site_id":56},571127,1792172120,{"code":4,"msg":5,"data":127},{"doc_id":124,"user_id":128,"nickname":88,"user_avatar":129,"doc_module":9,"category_id":50,"category_name":51,"doc_title":59,"doc_description":61,"doc_content":130,"file_id":131,"file_url":132,"file_type":133,"file_size":134,"view_count":79,"is_deleted":4,"is_public":9,"is_downloadable":9,"audit_status":9,"page_count":25,"language":135,"language_code":57,"site_id":56,"html_lang":57,"table_of_contents":136,"faqs":137,"seo_title":138,"seo_description":61,"update_tm":139,"read_time":47},962085320529,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals  \nJonas Brorson Jensen , Ole L. Dollerup , Andreas B. Møller , Tine B. Billeskov , Emilie Dalbram , Sabina Chubanava , Mads V. Damgaard , Ryan W. Dellinger , Kajetan Trošt, Thomas Moritz , Steffen Ringgaard , Niels Møller , Jonas T. Treebak, Jean Farup , Niels Jessen  \nJCI Insight. 2022;7(19):e158314 . [https://doi.org/10.1172/jci.insight.158314](https://doi.org/10.1172/jci.insight.158314) .  \n Clinical Research and Public Health   Aging   Muscle biology   \nDuring aging , there is a functional decline in the pool of muscle stem cells (MuSCs) that influences the functional and regenerative capacity of skeletal muscle. Preclinical evidence has suggested that nicotinamide riboside (NR) and pterostilbene (PT) can improve muscle regeneration , e.g. , by increasing MuSC function. The objective of this study was to investigate if supplementation with NR and PT (NRPT) promotes skeletal muscle regeneration after muscle injury in elderly individuals by improved recruitment of MuSCs.  \nThirty-two elderly individuals (55–80 years of age) were randomized to daily supplementation with either NRPT (1 ,000 mg NR and 200 mg PT) or matched placebo. Two weeks after initiation of supplementation , skeletal muscle injury was induced by electrically induced eccentric muscle work. Skeletal muscle biopsies were obtained before , 2 hours after , and 2 , 8 , and 30 days after injury.  \nA substantial skeletal muscle injury was induced by the protocol and associated with release of myoglobin and creatine kinase , muscle soreness , tissue edema , and a decrease in muscle strength. MuSC content , proliferation , and cell size revealed a large demand for recruitment after injury , but this was not affected by NRPT. Furthermore , histological analyses of muscle fiber area , central nuclei, and embryonic myosin heavy chain showed no NRPT supplementation effect.  \nDaily supplementation with 1 ,000 mg NR and 200 mg PT is safe but does not improve […]  \nFind the latest version:  \n[https://jci.me/158314/pdf](https://jci.me/158314/pdf)  \nCLINIC AL  \nMEDICINE  \nAuthorship note: JF and NJ contributed equally to this work.  \nConflict of interest: RWD is employed by Elysium Health and has stock options.  \nCopyright: © 2022, Jensen et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License.  \nSubmitted: January 7, 2022  \nAccepted: August 19, 2022  \nPublished: October 10, 2022  \nReference information: JCI Insight. 2022;7(19):e158314 .  \n[https://doi.org/10.1172/jci](https://doi.org/10.1172/jci). insight.158314 .  \nA randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals  \nJonas Brorson Jensen,1,2,3 Ole L. Dollerup,2,3,4 Andreas B. Møller,2,3 Tine B. Billeskov,2,3,4 Emilie Dalbram,5 Sabina Chubanava,5 Mads V. Damgaard,5 Ryan W. Dellinger,6 Kajetan Trošt,5 Thomas Moritz,5 Steffen Ringgaard,7 Niels Møller,4,8 Jonas T. Treebak,5 Jean Farup,1,2,3 and Niels Jessen1,2,3  \n1Department of Biomedicine and 2Research Laboratory for Biochemical Pathology, Department of Biomedicine, Aarhus University, Aarhus, Denmark. 3Steno Diabetes Center Aarhus and 4Diabetes and Hormonal Diseases, Aarhus University Hospital, Aarhus, Denmark. 5Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), University of Copenhagen, Copenhagen, Denmark. 6Elysium Health, New York, New York, USA. 7Magnetic Resonance Research Centre, Department of Clinical Medicine, and 8Medical Research Laboratory, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.  \nBACKGROUND. During aging, there is a functional decline in the pool of muscle stem cells (MuSCs) that influences the functional and regenerative capacity of skeletal muscle. Preclinical evidence has suggested that nicotinamide ri","cbCaidTRoOWnD6x8","https://ap.wps.com/l/cbCaidTRoOWnD6x8","pdf",1693684,"English","# Background\n# Methods\n# Results\n# Conclusion\n# Trial registration\n# Funding\n# Introduction","[{\"question\":\"What was the main goal of the NRPT supplementation trial?\",\"answer\":\"To determine whether nicotinamide riboside and pterostilbene supplementation (NRPT) promotes skeletal muscle regeneration after experimental injury in elderly individuals, by improving MuSC recruitment.\"},{\"question\":\"How was the study designed and how many participants were included?\",\"answer\":\"Thirty-two elderly individuals (55–80 years) were randomized to daily NRPT (1,000 mg NR and 200 mg PT) or matched placebo, followed by electrically induced eccentric muscle injury.\"},{\"question\":\"Did NRPT improve muscle recovery after injury?\",\"answer\":\"No. NRPT did not affect MuSC content, proliferation, cell size, histological measures (muscle fiber area, central nuclei, embryonic myosin heavy chain), or other indicators of muscle recovery.\"}]","A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals | PDF",1791894626]