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Le travail étudie leur intérêt comme alternatives aux antibiotiques conventionnels, dans un cadre de recherche expérimentale mené à l’Institut des Sciences Moléculaires de Marseille (équipes BiosCiences et Adisseo). Le document présente le contexte académique, les responsables scientifiques et le jury, ainsi que des remerciements détaillés aux collaborateurs et équipes impliqués dans différentes étapes du projet.",{"@graph":58,"@context":114},[59,76,97],{"@type":60,"itemListElement":61},"BreadcrumbList",[62,67,70,73],{"item":63,"name":64,"@type":65,"position":66},"https://docshare.wps.com","Home","ListItem",1,{"item":68,"name":9,"@type":65,"position":69},"https://docshare.wps.com/fr/document/",2,{"item":71,"name":42,"@type":65,"position":72},"https://docshare.wps.com/fr/document/santé-soins/",3,{"item":74,"name":54,"@type":65,"position":75},"https://docshare.wps.com/fr/document/ruminococcins-c-a-new-family-of-sactipeptides-as-alternatives-to-conventional-antibiotics/514634/",4,{"url":74,"name":54,"@type":77,"image":78,"author":83,"headline":54,"publisher":86,"fileFormat":89,"inLanguage":52,"description":56,"dateModified":90,"datePublished":91,"encodingFormat":89,"isAccessibleForFree":92,"interactionStatistic":93},"DigitalDocument",{"url":79,"@type":80,"width":81,"height":82},"https://docshare.wps.com/thumbnails/ruminococcins-c-a-new-family-of-sactipeptides-as-alternatives-to-conventional-antibiotics/514634.png","ImageObject",300,407,{"name":84,"@type":85},"Guten Appetit_Joghurt","Person",{"url":63,"name":87,"@type":88},"DocShare","Organization","application/pdf","2026-10-16","2026-10-06",true,{"@type":94,"interactionType":95,"userInteractionCount":69},"InteractionCounter",{"@type":96},"ViewAction",{"@type":98,"mainEntity":99},"FAQPage",[100,106,110],{"name":101,"@type":102,"acceptedAnswer":103},"Quel est le sujet principal de la thèse ?","Question",{"text":104,"@type":105},"La thèse porte sur « Les Ruminococcines C », présentées comme une nouvelle famille de sactipeptides, explorée comme alternative aux antibiotiques conventionnels.","Answer",{"name":107,"@type":102,"acceptedAnswer":108},"Où et sous quelle direction la thèse a-t-elle été réalisée ?",{"text":109,"@type":105},"Le document indique une réalisation à l’Institut des Sciences Moléculaires de Marseille, au sein des équipes BiosCiences et Adisseo, sous la direction de Josette Perrier, Michael Lafond et Estelle Devillard.",{"name":111,"@type":102,"acceptedAnswer":112},"Quand la thèse a-t-elle été soutenue ?",{"text":113,"@type":105},"La soutenance est indiquée le 14 Septembre 2020.","https://schema.org",{"og:url":74,"og:type":116,"og:title":54,"og:site_name":87,"og:description":56},"article",{"robots":118,"canonical":74},"index,follow",{"doc_id":120,"site_id":51},514634,1792168198,{"code":4,"msg":5,"data":123},{"doc_id":120,"user_id":124,"nickname":84,"user_avatar":125,"doc_module":4,"category_id":41,"category_name":42,"doc_title":54,"doc_description":56,"doc_content":126,"file_id":127,"file_url":128,"file_type":129,"file_size":130,"view_count":69,"is_deleted":4,"is_public":66,"is_downloadable":66,"audit_status":66,"page_count":131,"language":132,"language_code":52,"site_id":51,"html_lang":52,"table_of_contents":133,"faqs":134,"seo_title":135,"seo_description":56,"update_tm":136,"read_time":137},1374408768420,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","THÈSE DE DOCTORAT  \nD’AIX-MARSEILLE UNIVERSITÉ  \nSpécialité : Microbiologie  \nÉcole doctorale nº062: Sciences de la vie et de la santé  \nréalisée  \nà l’Institut des Sciences Moléculaires de Marseille-Equipe  \nBiosCiences et Adisseo  \nsous la direction de Josette Perrier, Michael Lafond, Estelle Devillard  \nprésentée par  \nClarisse ROBLIN  \npour obtenir le grade de :  \nDOCTEUR D’AIX-MARSEILLE UNIVERSITÉ  \nSujet de la thèse :  \nLes Ruminococcines C, une nouvelle famille desactipeptides comme alternatives aux antibiotiques  \nconventionnels  \nThesis subject :  \nRuminococcins C, a new family of sactipeptides as alternatives to conventional antibiotics  \nsoutenue le 14 Septembre 2020  \ndevant le jury composé de :  \nM . Marc FONTECAVE Président du jury Mme Sylvie REBUFFAT Rapportrice  \nM . Lhousseine TOUQUI Rapporteur  \nM . Patrice POLARD Examinateur  \nMme Josette PERRIER Directrice de thèse  \nMme Estelle DEVILLARD Directrice de thèse  \nM . Michael LAFOND Directeur de thèse  \nM . Victor DUARTE Invité  \nAcknowledgements  \nFirst, I would like to express my deepest appreciation to all the jury members, Sylvie Rebuffat, Lhousseine Touqui, Marc Fontecave and Patrice Polard for accepting to read and evaluate this work and I would like to thank them in advance for their presence atthe defense.  \nI would also like to thank my committee members, Delphine Destoumieux-Garzon and Aurélie Tasiemski for accepting to review my work along the project and for giving me their helpful insights.  \nI express my gratitude to the head of BiosCiences, Thierry Tron, and the head of the Institute des Sciences Moléculaires de Marseille, Jean Rodriguez, for giving me the opportunity to do research in this lab. In addition, I would like to thank Adisseo for their participation in a CIFRE convention and for financing my thesis project.  \nI would like to express my deepest gratitude to my thesis advisors: Estelle Devillard, Josette Perrier and Mickael Lafond. Estelle, it was always a pleasure to work with you and I learn from you skills that I wouldn’t have been exposed to in a \"purely academic PhD\", for that I am thankful. Josette and Mickael, I am glad I joined you on this great RumC project and I am grateful for the journey we took together. It took us some time to find our pace, but once we did, I enjoyed every moment we worked together. Thankyou for the trust you put in me everyday and for your support. In particular, I want to emphasize my gratitude to Mickael for his constant involvement in this project and for helping me to reach my full potential.  \nThrough this project I had the opportunity to discover how competitive research can be and how it can sometimes be an obstacle to our field but above all this project brought to light the best that collaborative work has to offer. It is amazing to see what we can achieve when people from different backgrounds truly work together. Thus, I would like to thank our many collaborators.  \nFirst, the people from Grenoble: Victor, Hamid, Christian, Sylvie, Yohann and Steve, it was a pleasure to work with you and share this wonderful RumC project with you all these years. It was also a pleasure to travel with you, visit you in Grenoble or welcome you in Marseille and spend time together outside of the frame of work. To Steve, in particular, I am grateful, we had the opportunity to \"share\" a PhD, never in competition but always supporting each other’s. I hope our professional paths will cross again! Victor, I am thankful you accepted to be in my jury too. You already know most of the content of this manuscript so it might be a little long to read but you might find a few surprisesat the end.  \nThen, I would like to thank the people from IMM: Françoise, Olivier and Matthieu. Thank you for your dedication to the resolution of RumC1’s structure and to Olivier,  \nthanks for the coffee whenever I was at the IMM microscopy platform. Speaking of the microscopy platform, I would like to address a huge thanks to Artemis and Hugo for alw","cbCaiafdOkhCvGh3","https://ap.wps.com/l/cbCaiafdOkhCvGh3","pdf",17171333,327,"French","# Informations de thèse\n## Sujet, spécialité et institution\n## Soutenance et jury\n# Remerciements","[{\"question\":\"Quel est le sujet principal de la thèse ?\",\"answer\":\"La thèse porte sur « Les Ruminococcines C », présentées comme une nouvelle famille de sactipeptides, explorée comme alternative aux antibiotiques conventionnels.\"},{\"question\":\"Où et sous quelle direction la thèse a-t-elle été réalisée ?\",\"answer\":\"Le document indique une réalisation à l’Institut des Sciences Moléculaires de Marseille, au sein des équipes BiosCiences et Adisseo, sous la direction de Josette Perrier, Michael Lafond et Estelle Devillard.\"},{\"question\":\"Quand la thèse a-t-elle été soutenue ?\",\"answer\":\"La soutenance est indiquée le 14 Septembre 2020.\"}]","Les Ruminococcines C - une nouvelle famille de sactipeptides comme alternatives aux antibiotiques conventionnels | PDF",1791300934,504]