[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-141605-es":3,"doc-seo-141605-110":30,"detail-sidebar-cat-0-es-110":91},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":4,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":27,"seo_description":14,"update_tm":28,"read_time":29},141605,962084925782,"Chloe Bennett","https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc",41,"Investigación e Informes","p53 expresado en la mucosa gástrica de pacientes infectados por Helicobacter pylori - estudio prospectivo","Helicobacter pylori (Hp) se reconoce como carcinógeno tipo 1 asociado con lesiones preneoplásicas (atrofia y metaplasia intestinal). La relación entre Hp y p53, regulador clave del ciclo celular, ha mostrado resultados contradictorios. Se analizó la expresión de p53 en mucosa gástrica y su vínculo con la infección por Hp mediante un estudio prospectivo, observacional, transversal de 3 meses, con biopsias según Sydney y evaluación histopatológica. Se observó asociación entre Hp y p53 y entre p53 y metaplasia intestinal, incluso cuando el Hp ya no estaba presente.","Revista de Gastroenterología de México. 2013;78(1):12-20  \n[www.elsevier.es/rgmx](www.elsevier.es/rgmx)  \nORIGINAL ARTICLE  \np53 expression in the gastric mucosa of patients infected with Helicobacter pyloriq  \nG.A. Morales-Fuentesa,*, A. Zarate-Osornob, E.E . Quiñónez-Urregoc,  \nM . Antonio-Manriqued, C.L . Martínez-Garcíaa, P. Figueroa-Barojase,  \nY. Zamorano-Orozcoa, S.E . Leal-Osunaf, C . Martínez-Camachoa, L.A. Mejía-Cuána,  \nC.A. Rivera-Navaa, X . Sánchez-Cháveza, M.A. Ramírez-Ramíreza  \naGastrointestinal Endoscopy Service, Hospital General Regional No. 1 “Dr. Carlos MacGregor Sánchez Navarro”, IMS, Mexico City, Mexico  \nbPathology Department, Hospital Español de México, Mexico City, Mexico  \ncPathology Department, Centro Médico Nacional La Raza, Hospital de Especialidades, IMSS, Mexico City, Mexico  \ndGastrointestinal Endoscopy Service, Hospital Juárez de México, SSA, Mexico City, Mexico eGastrointestinal Endoscopy Service, Hospital Ángeles Lindavista, Mexico City, Mexico fInternal Medicine Department, Hospital General de Atizapán, SSA, State of Mexico, Mexico  \nReceived 6 September 2012; accepted 26 November 2012 Available online 29 January 2013  \nKEYWORDS  \np53;  \nHelicobacter pylori; Immunohistochemistry; Gastritis;  \nMexico  \nAbstract  \nBackground: Helicobacter pylori (Hp) is recognized as a type 1 carcinogen for gastric cancer associated with pre-neoplastic lesions (atrophy and intestinal metaplasia [IM]) . Its relation with p53, which intervenes in the cell cycle, has had contradictory results.  \nAims: To analyze p53 expression in gastric mucosa and its relation with Hp infection.  \nMethods: A 3-month prospective, observational, cross-sectional study was conducted. Patients that had no evidence of acute or clinically signiicant gastric pathology had biopsies taken according to the Sydney system at the Hospital Juárez de México and the histopathologic studies were done at the Hospital Español de México.  \nResults: Hp prevalence was 32.7% in 104 patients. There were no cases of atrophy or dysplasia. A total of 91% of the infected patients were positive for p53 . Of the non-infected patients, 14% were positive for p53 and 60% of them had IM. Of the IM patients, 75% presented with positive p53 . Of the patients without IM, 31 presented with positive p53, and Hp was positive in 85% of  \nqPlease cite this article as: Morales-Fuentes GA, et al. p53 expresado en la mucosa gástrica de pacientes infectados por Helicobacter pylori. Revista de Gastroenterología de México. 2013;78:12-20.  \n*Corresponding author: C/ Enrique González Martínez \\#18, Circuito Poetas, Colonia Ciudad Satélite, CP 53100, Naucalpan de Juárez, Estado de México, Mexico. Tel.: 55-62-58-77 and 59-14-52-50.  \nEmail address: [gerar3d@yahoo.com](gerar3d@yahoo.com) (G.A. Morales-Fuentes).  \n2255-534X/$ -see front matter © 2012 Asociación Mexicana de Gastroenterología. Published by Masson Doyma México S.A. Todos los derechos reservados.  \nPALABRAS CLAVE  \np53;  \nHelicobacter pylori; Inmunohistoquímica; Gastritis;  \nMéxico  \nthem. There was association between Hp and p53 and between p53 and IM (P .0001 and P .0006, respectively) .  \nConclusions: Signiicant association was shown between Hp and p53 expression, even in patients with pre‑neoplastic lesions that no longer presented with Hp. Given that the identiication of pre-neoplastic lesions is important for the prevention of cancer, immunohistochemistry could beneit routine biopsy carried out during endoscopy for the detection of Hp, by identifying patients with expression of the important oncogene regulator, p53 .  \n© 2012 Asociación Mexicana de Gastroenterología. Published by Masson Doyma México S.A.  \nAll rights reserved.  \np53 expresado en la mucosa gástrica de pacientes infectados por Helicobacter pylori  \nResumen  \nAntecedentes: Helicobacter pylori (Hp) es reconocido como carcinógeno tipo 1 para cáncergástrico, ya que se asocia a lesiones preneoplásicas (atroia y metaplasia intestinal (MI)), y surelación c","cbCaiktjHqRwuWHz","https://ap.wps.com/l/cbCaiktjHqRwuWHz","pdf",410759,1,9,"Spanish","es",110,"# Resumen\n## Antecedentes\n## Objetivos\n## Métodos\n## Resultados\n## Conclusiones\n# Introducción\n## Gastritis e infección por Helicobacter pylori","[{\"question\":\"Cuál fue el objetivo principal del estudio sobre p53 y Helicobacter pylori?\",\"answer\":\"Analizar la expresión de p53 en la mucosa gástrica y su relación con la infección por Helicobacter pylori (Hp).\"},{\"question\":\"Cómo se realizó el estudio y qué tipo de muestras se analizaron?\",\"answer\":\"Se efectuó un estudio prospectivo, observacional, transversal de 3 meses. Se tomaron biopsias según el sistema de Sydney y se realizaron estudios histopatológicos en el marco del protocolo descrito.\"},{\"question\":\"Qué hallazgos se reportaron respecto a la asociación entre Hp, p53 y metaplasia intestinal?\",\"answer\":\"Se encontró asociación significativa entre Hp y p53, y entre p53 y metaplasia intestinal. La expresión de p53 se observó en la población infectada y también en pacientes sin Hp, aun con lesiones preneoplásicas.\"}]","p53 expresado en la mucosa gástrica de pacientes infectados por Helicobacter pylori - estudio prospectivo | PDF",1787660709,14,{"code":4,"msg":31,"data":32},"ok",{"site_id":24,"language":23,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":86,"head_meta":88,"extra_data":90,"updated_unix":28},"p53-expression-in-the-gastric-mucosa-of-patients-infected-with-helicobacter-pylori-prospective-study","",{"@graph":36,"@context":85},[37,54,68],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,48,51],{"item":41,"name":42,"@type":43,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":47},"https://docshare.wps.com/es/document/","Document",2,{"item":49,"name":12,"@type":43,"position":50},"https://docshare.wps.com/es/document/investigación-e-informes/",3,{"item":52,"name":13,"@type":43,"position":53},"https://docshare.wps.com/es/document/p53-expression-in-the-gastric-mucosa-of-patients-infected-with-helicobacter-pylori-prospective-study/141605/",4,{"url":52,"name":13,"@type":55,"author":56,"headline":13,"publisher":58,"fileFormat":61,"inLanguage":23,"description":14,"dateModified":62,"datePublished":62,"encodingFormat":61,"isAccessibleForFree":63,"interactionStatistic":64},"DigitalDocument",{"name":9,"@type":57},"Person",{"url":41,"name":59,"@type":60},"DocShare","Organization","application/pdf","2026-08-25",true,{"@type":65,"interactionType":66,"userInteractionCount":4},"InteractionCounter",{"@type":67},"ViewAction",{"@type":69,"mainEntity":70},"FAQPage",[71,77,81],{"name":72,"@type":73,"acceptedAnswer":74},"Cuál fue el objetivo principal del estudio sobre p53 y Helicobacter pylori?","Question",{"text":75,"@type":76},"Analizar la expresión de p53 en la mucosa gástrica y su relación con la infección por Helicobacter pylori (Hp).","Answer",{"name":78,"@type":73,"acceptedAnswer":79},"Cómo se realizó el estudio y qué tipo de muestras se analizaron?",{"text":80,"@type":76},"Se efectuó un estudio prospectivo, observacional, transversal de 3 meses. Se tomaron biopsias según el sistema de Sydney y se realizaron estudios histopatológicos en el marco del protocolo descrito.",{"name":82,"@type":73,"acceptedAnswer":83},"Qué hallazgos se reportaron respecto a la asociación entre Hp, p53 y metaplasia intestinal?",{"text":84,"@type":76},"Se encontró asociación significativa entre Hp y p53, y entre p53 y metaplasia intestinal. La expresión de p53 se observó en la población infectada y también en pacientes sin Hp, aun con lesiones preneoplásicas.","https://schema.org",{"og:url":52,"og:type":87,"og:title":13,"og:site_name":59,"og:description":14},"article",{"robots":89,"canonical":52},"index,follow",{"doc_id":7,"site_id":24},{"code":4,"msg":5,"data":92},[93,98,102,106,110,112,116,120,124,128],{"id":94,"doc_module":4,"doc_module_name":46,"category_name":95,"show_sort_weight":96,"slug":97},39,"Cómic",60,"comic",{"id":99,"doc_module":4,"doc_module_name":46,"category_name":100,"show_sort_weight":96,"slug":101},43,"Estilo de Vida","lifestyle",{"id":103,"doc_module":4,"doc_module_name":46,"category_name":104,"show_sort_weight":96,"slug":105},38,"Examen","exam",{"id":107,"doc_module":4,"doc_module_name":46,"category_name":108,"show_sort_weight":96,"slug":109},44,"General","general",{"id":11,"doc_module":4,"doc_module_name":46,"category_name":12,"show_sort_weight":96,"slug":111},"research-report",{"id":113,"doc_module":4,"doc_module_name":46,"category_name":114,"show_sort_weight":96,"slug":115},37,"Literatura","literature",{"id":117,"doc_module":4,"doc_module_name":46,"category_name":118,"show_sort_weight":96,"slug":119},22,"Relatos y Novelas","story-novel",{"id":121,"doc_module":4,"doc_module_name":46,"category_name":122,"show_sort_weight":96,"slug":123},42,"Religión y Espiritualidad","religion-spirituality",{"id":125,"doc_module":4,"doc_module_name":46,"category_name":126,"show_sort_weight":96,"slug":127},40,"Salud y Atención Médica","healthcare",{"id":129,"doc_module":4,"doc_module_name":46,"category_name":130,"show_sort_weight":96,"slug":131},24,"Tecnología","technology"]