[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-365236-105":59,"doc-detail-365236-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","ythdf1rnf7p27-axis-promotes-prostate-cancer-progression-article","YTHDF1/RNF7/p27 axis promotes prostate cancer progression - Article","","Prostate cancer is a common malignancy in men with high incidence and mortality, and early-stage disease often lacks clear symptoms, delaying detection until middle or late stages. Current treatments, including androgen deprivation therapy, face limited effectiveness due to inevitable drug and radiation resistance, leaving a need for new biomarkers and therapeutic targets. This work focuses on the YTHDF1/RNF7/p27 axis within the m6A modification pathway as a regulator of prostate cancer progression, aiming to clarify underlying mechanisms and support future targeted treatments.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ythdf1rnf7p27-axis-promotes-prostate-cancer-progression-article/365236/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ythdf1rnf7p27-axis-promotes-prostate-cancer-progression-article/365236.png","ImageObject",300,407,{"name":92,"@type":93},"Mia  ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is early screening important for prostate cancer?","Question",{"text":112,"@type":113},"Early symptoms can be subtle, so prostate cancer is often detected only after it progresses. Screening improves the chance of earlier identification and intervention.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What limits current prostate cancer therapies?",{"text":117,"@type":113},"Treatments such as androgen deprivation therapy are constrained because drug and radiation resistance commonly develop, leading to deterioration and metastasis.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the study’s focus regarding YTHDF1 and m6A?",{"text":121,"@type":113},"The study highlights YTHDF1 as a reader protein in the m6A modification pathway and investigates its regulatory role in prostate cancer progression through the YTHDF1/RNF7/p27 axis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},365236,1790927167,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},687207024478,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","[www.nature.com/cddis](www.nature.com/cddis)  \nARTICLE OPEN   \nYTHDF1/RNF7/p27 axis promotes prostate cancer progression  \nYulin Shi 1,2,3,8, Baiyang Liu1,2,8, Yong Zhang4,8, Sen Zhao2,8, Li Zuo5, Jun Pu3, Haoqing Zhai2, Dengcai Mu2, Jia Du2, Yan Cheng 1 ✉, Cuiping Yang6,7 ✉ and Yongbin Chen 1,2 ✉  \n© The Author(s) 2025  \nINTRODUCTION  \nProstate cancer (PCa) is a prevalent malignant tumor in the urinary system, and it remains the most common male tumor, according to the latest cancer statistics in the United States [1] . Prostate cancer alone accounts for one-fifth of newly diagnosed cases, and the death rate of prostate cancer also ranks second among male tumors [1] . Older age, genetic mutations, diet, and inflammation are significant factors in the etiology of PCa [2] . Previous reports have shown that PCa is rare in eastern countries due to the diet habit dominated by plants [2] . However, based on the statistical data of cancer in China from 2000 to 2011, with the improvement of living standards in our country, the aggravation of environmental pollution, and the gradual westernization of dietary structure, the incidence and mortality of prostate cancer have also increased significantly [3] .  \nProstate cancer diagnosis involves prostate biopsy, supported by prostate-specific antigen (PSA) testing, magnetic resonance imaging (MRI), digital rectal examination, and/or health screening. However, due to the subtlety of early symptoms in prostate cancer, the disease is frequently not detected until it has progressed to the middle or late stages, when symptoms become more apparent. Therefore, early screening for prostate cancer holds significant importance [4–7] . Currently, the clinical approaches for the treatment of prostate cancer primarily encompass surgical intervention, radiotherapy, chemotherapy,  \nand endocrine therapy, among others [8] . The standard primary therapy for metastatic PCa is androgen deprivation therapy (ADT) by surgical or medical castration [2] . Despite the above available treatment options, the therapeutic effects are still greatly constrained, drug- and radio-resistance will almost inevitably occur, which eventually leads to further deterioration and metastasis of tumors. The discovery of novel cancer biomarkers holds potential for the targeted treatment of prostate cancer (PCa) . A growing body of evidence highlights the genetic contributions to prostate cancer, including identifying common genes that function as biomarkers for this disease, including BRCA genes, RNase L (HPC1, lq22), HOX genes, and the ATM gene [8] . Mutations in androgen receptors have been associated with the emergence of androgen resistance receptor-targeted therapies [9] . Malfunctions in the signaling pathways, including the MAPK/ERK pathway, AR (androgen receptor) related pathways, and the contribution of Akt/PI3K pathways to ADT resistance have been established[10] . Biomarkers are anticipated to delineate precise treatment specifications for cancer. However, existing clinical therapies tend to benefit only a limited subset of patients and are often associated with numerous side effects that significantly diminish the quality of life for the majority of patients. Consequently, there remains an urgent necessity to screen novel molecules that influence the onset and progression of prostate cancer, as well as to elucidate their functions and underlying  \n1The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 2State Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. 3Department of Neurosurgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. 4Department of Pathology, Cancer Hospital of China Medical University, Shenyang, Liaoning, China. 5The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Changzhou Second People’s Hospital, Changzhou Medical Center, Nanjing Medical Universi","cbCaidcVGA0jnrVk","https://ap.wps.com/l/cbCaidcVGA0jnrVk","pdf",7877686,12,"English","# Introduction\n## Epidemiology and risk factors\n## Diagnosis and current treatment constraints\n## Rationale for novel biomarkers\n## Hypoxia/m6A pathway background and YTHDF1 role","[{\"question\":\"Why is early screening important for prostate cancer?\",\"answer\":\"Early symptoms can be subtle, so prostate cancer is often detected only after it progresses. Screening improves the chance of earlier identification and intervention.\"},{\"question\":\"What limits current prostate cancer therapies?\",\"answer\":\"Treatments such as androgen deprivation therapy are constrained because drug and radiation resistance commonly develop, leading to deterioration and metastasis.\"},{\"question\":\"What is the study’s focus regarding YTHDF1 and m6A?\",\"answer\":\"The study highlights YTHDF1 as a reader protein in the m6A modification pathway and investigates its regulatory role in prostate cancer progression through the YTHDF1/RNF7/p27 axis.\"}]","YTHDF1/RNF7/p27 axis promotes prostate cancer progression - Article | PDF",1790160424]