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This prospective study evaluates whether heavy substance use in young adulthood predicts poor self-rated memory in late midlife, and whether early midlife problematic substance use mediates these associations. Using the Monitoring the Future Panel (N=14,659), analyses test alcohol, binge drinking, cannabis, and cigarette exposures across young adulthood, disorder symptoms at age 35, and memory outcomes at ages 50-65.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/young-adult-substance-use-as-a-predictor-of-poor-memory-decades-later-in-midlife/426183/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/young-adult-substance-use-as-a-predictor-of-poor-memory-decades-later-in-midlife/426183.png","ImageObject",300,407,{"name":92,"@type":93},"Adam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-19","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What is the study’s main goal regarding memory and substance use?","Question",{"text":112,"@type":113},"To test whether heavy substance use during young adulthood is associated with poor self-rated memory decades later in midlife, and to determine whether early midlife problematic substance use mediates this link.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What data source and sample size were used?",{"text":117,"@type":113},"The study uses the Monitoring the Future (MTF) Panel study, with N=14,659 participants, collecting substance use data across multiple time points and assessing memory in late midlife.",{"name":119,"@type":110,"acceptedAnswer":120},"How did young adult alcohol and binge drinking relate to later poor memory?",{"text":121,"@type":113},"Heavy alcohol use and binge drinking were associated with higher odds of early midlife disordered alcohol use and with late midlife poor memory. Alcohol showed partial mediation, while binge drinking showed full mediation through early midlife disordered substance use.",{"name":123,"@type":110,"acceptedAnswer":124},"Did cigarette use and cannabis show the same mediation pattern?",{"text":125,"@type":113},"Young adult heavy cannabis use predicted early midlife disordered use and late midlife poor memory with full mediation. Young adult daily cigarette use was directly associated with late midlife poor memory, with no evidence of mediation.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},426183,1790790822,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":81},1374404737137,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","1210 Innovation in Aging, 2025, Vol. 9, No. S2  \nSubjective memory decline is an early sign of cognitive decline and dementia. Understanding risk factors associated with midlife poor memory is crucial for effective prevention. This study prospectively examines associations between young adult (YA) heavy substance use and late midlife poor memory, and the mediating role of early midlife problematic substance use. Data on number of waves ofYA (age 18-30) heavy alcohol, binge drinking, cannabis and cigarette use, early midlife (age 35) substance use disorder symptoms and heavy cigarette use, and late midlife poor self-rated memory (age 50-65) were from the Monitoring the Future (MTF) Panel study (N = 14,659) . Mediation analyses assessed whether early midlife problematic substance use mediated YA heavy substance use associations with late midlife poor memory. YA heavy alcohol use and binge drinking were associated with higher odds of early midlife disordered (vs. non-disordered) alcohol use (AOR=1.69 and 1.66, both p\u003C.001), and with late midlife poor memory (AOR=1.34 and 1.39, both p\u003C.001). Partial mediation for alcohol (AOR=1.17, p\u003C.001) and full mediation for binge drinking (AOR=1.18, p\u003C.001) were observed. YA heavy cannabis use was associated with early midlife disordered use (vs. non-disordered; AOR=1.42, p\u003C.001), and with late midlife poor memory (AOR 1.41, p = 0.008); full mediation (AOR=1.13, p = 0.010) was observed. YA daily cigarette use was directly associated with late midlife poor memory (AOR=1.05, p = 0.047), with no evidence of mediation. These findings underscore long-term risks of sustained YA substance use for cognition, and indicate that long-term associations may partially or completely operate through early midlife disordered substance use.  \nAbstract citation ID: igaf122.4050  \nYOUNG ADULT SUBSTANCE USE AS A PREDICTOR  \nOF POOR MEMORY DECADES LATER IN MIDLIFE  \nYuk Pang, Yvonne Terry-McElrath, Joy Bohyun Jang, and Megan Patrick, University of Michigan, Ann Arbor, Michigan, United States","cbCaifrxbcbNf1Pq","https://ap.wps.com/l/cbCaifrxbcbNf1Pq","pdf",1062160,"English","# Study Objective\n## Mediation Framework\n# Data and Measures\n## Young Adulthood Exposures\n## Early Midlife Symptoms\n## Late Midlife Memory Outcome\n# Key Findings\n## Alcohol and Binge Drinking\n## Cannabis and Cigarette Use\n# Implications for Prevention","[{\"question\":\"What is the study’s main goal regarding memory and substance use?\",\"answer\":\"To test whether heavy substance use during young adulthood is associated with poor self-rated memory decades later in midlife, and to determine whether early midlife problematic substance use mediates this link.\"},{\"question\":\"What data source and sample size were used?\",\"answer\":\"The study uses the Monitoring the Future (MTF) Panel study, with N=14,659 participants, collecting substance use data across multiple time points and assessing memory in late midlife.\"},{\"question\":\"How did young adult alcohol and binge drinking relate to later poor memory?\",\"answer\":\"Heavy alcohol use and binge drinking were associated with higher odds of early midlife disordered alcohol use and with late midlife poor memory. Alcohol showed partial mediation, while binge drinking showed full mediation through early midlife disordered substance use.\"},{\"question\":\"Did cigarette use and cannabis show the same mediation pattern?\",\"answer\":\"Young adult heavy cannabis use predicted early midlife disordered use and late midlife poor memory with full mediation. Young adult daily cigarette use was directly associated with late midlife poor memory, with no evidence of mediation.\"}]","Young Adult Substance Use as a Predictor of Poor Memory Decades Later in Midlife | PDF",1790639648]