[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330240-105":59,"doc-detail-330240-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","worldwide-research-trends-on-tumor-burden-and-immunotherapy-a-bibliometric-analysis-review-article","Worldwide research trends on tumor burden and immunotherapy: a bibliometric analysis - Review Article","","Various immunotherapies are increasingly incorporated into malignant cancer treatment across different degrees of tumor burden. Researchers have made substantial progress in clarifying how tumor burden relates to immunotherapy. This review used a bibliometric approach to map field prospects and developing trends by analyzing Web of Science Core Collection records. Bibliometrix, VOSviewer, and CiteSpace quantified key features, collaborations, keyword networks, and citation bursts across 1,030 publications.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/worldwide-research-trends-on-tumor-burden-and-immunotherapy-a-bibliometric-analysis-review-article/330240/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/worldwide-research-trends-on-tumor-burden-and-immunotherapy-a-bibliometric-analysis-review-article/330240.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-09","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the goal of this bibliometric review on tumor burden and immunotherapy?","Question",{"text":113,"@type":114},"To explore prospects and developing trends in tumor burden and immunotherapy from a bibliometric perspective.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which data source and tools were used to conduct the analysis?",{"text":118,"@type":114},"Articles were collected from the Web of Science Core Collection (WoSCC). Bibliometrix, VOSviewer, and CiteSpace were used for bibliometric features, visualization, collaboration/keyword analysis, and citation burst detection.",{"name":120,"@type":111,"acceptedAnswer":121},"What major findings are reported about publication output and research hotspots?",{"text":122,"@type":114},"The United States and China published the most articles; highly productive journals included Cancer Immunology Immunotherapy and Journal for ImmunoTherapy of Cancer. Hot citation burst keywords in recent years included nivolumab, tumor microenvironment, and immune checkpoint inhibitor.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},330240,1790113519,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":41,"preview_page_count":4},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","’Review Article  \nWorldwide research trends on tumor burden and immunotherapy: a bibliometric analysis  \nLei Zhang, MD, Han Zheng, MSc, Shi-Tao Jiang, MD, Yao-Ge Liu, MD, Ting Zhang, MD, Jun-Wei Zhang, MD, Xin Lu, MD, Hai-Tao Zhao, MD, Xin-Ting Sang, MD, Yi-Yao Xu, MD*  \nAbstract   \nVarious immunotherapy has been greatly applied to comprehensive treatment of malignant cancer under different degrees of tumor burden. Scientific researchers have gained considerable progress in the relationship between immunotherapy and tumor burden in recent years. This review aimed to explore the prospect and developing trends in the field of tumor burden and immunotherapy from a bibliometric perspective. Articles about tumor burden and immunotherapy were collected from the Web of Science Core Collection (WoSCC) (retrieved on 3 January 2023) . The R package ‘Bibliometrix’ analyzed the primary bibliometric features and created a threefiled plot to display the relationship between institutions, countries, and keywords. VOSviewer was used for co-authorship analysis, co-occurrence analysis, and their visualization. And CiteSpace calculated the citation burst references and keywords. A total of 1030 publications were retrieved from 35 years of scientific researches. The United States (US) and China published the most articles. The most productive journals were Cancer Immunology Immunotherapy and Journal for ImmunoTherapy of Cancer. The top one institution of the highest output was University of Texas MD Anderson Cancer Center. The hot keywords of strong citation burst strength in recent years were ‘nivolumab’, ‘tumor microenvironment’, and ‘immune checkpoint inhibitor ’. The most popular tumor type is melanoma. This bibliometric analysis mapped a basic knowledge structure. The field of tumor burden and immunotherapy is entering a rapid growing stage and keeping it value for future research.  \nKeywords: bibliometric, citespace, hotspot, immunotherapy, tumor burden, VOSviewer  \nIntroduction  \nImmunotherapy has been rapidly matured into a vigorous tooland occupied an important position in cancer therapies especially for unresectable and advanced cancer. No matter stimulating or inhibiting, immunotherapy has multifarious ways to modulate and alter one’s immune system response to treat a disease. Immunotherapy includes various concrete remedies: immune checkpoint inhibitors (ICI)[1–3], CAR (chimeric antigens receptor) T-cell therapy[4,5], cancer vaccines[6,7], cytokines[8,9], and  \nDepartment of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS and PUMC), Beijing, People’s Republic of China  \nLei Zhang and Han Zheng contributed equally to this work.  \nSponsorships or competing interests that maybe relevant to content are disclosed atthe end of this article.  \n*Corresponding author. Address: Peking Union Medical College Hospital (Dongdan campus), No. 1 Shuaifuyuan, Wangfujing, Dongcheng District 100730, Beijing, People’s Republic of China. Tel.: +86 010 69152830; fax: +86 010 69156042. [E-mail: xuyiyao@pumch.cn](E-mail: xuyiyao@pumch.cn) (Y.-Y. Xu).  \nCopyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms.  \nInternational Journal of Surgery (2024) 110:1699–1710  \nReceived 27 October 2023; Accepted 11 December 2023  \nSupplemental Digital Content is available for this article. Direct URL citations are provided in the HTML and PDF versions of this article on the journal's website, [www.lww.com/international-journal-of-surgery](www.lww.com/international-journal-of-surgery).  \nPublished online 4 January 2024  \n[http://dx.doi.org/10.1097/JS9.0000000000001022](http://dx.doi.org/10.1097","cbCaieeCCx21arlk","https://ap.wps.com/l/cbCaieeCCx21arlk","pdf",1249103,12,"English","# Abstract\n# Introduction\n# Methods and Bibliometric Tools\n## Bibliometrix\n## VOSviewer and CiteSpace\n# Results and Hotspots\n## Publication output and countries\n## Journals and institutions\n## Keyword bursts and tumor types","[{\"question\":\"What is the goal of this bibliometric review on tumor burden and immunotherapy?\",\"answer\":\"To explore prospects and developing trends in tumor burden and immunotherapy from a bibliometric perspective.\"},{\"question\":\"Which data source and tools were used to conduct the analysis?\",\"answer\":\"Articles were collected from the Web of Science Core Collection (WoSCC). Bibliometrix, VOSviewer, and CiteSpace were used for bibliometric features, visualization, collaboration/keyword analysis, and citation burst detection.\"},{\"question\":\"What major findings are reported about publication output and research hotspots?\",\"answer\":\"The United States and China published the most articles; highly productive journals included Cancer Immunology Immunotherapy and Journal for ImmunoTherapy of Cancer. Hot citation burst keywords in recent years included nivolumab, tumor microenvironment, and immune checkpoint inhibitor.\"}]","Worldwide research trends on tumor burden and immunotherapy: a bibliometric analysis - Review Article | PDF",1789987861]