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METHODS: Stem cell collection data from the last 300 patients at a community cancer center in Washington were reviewed, reporting collection methods, medications, timing, and outcomes. RESULTS and CONCLUSION support feasibility by routinely adding plerixafor to G-CSF on day 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of\u003Cbr>Clinical Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Oncol 2025 December 24; 16(12): 103683  \nDOI: 10.5306/wjco.v16.i12.103683 ISSN 2218-4333 (online)  \nORIGINAL ARTICLE  \nRetrospective Study  \nStem cell collection from peripheral blood of multiple myeloma patients  \nJonah Lee, Quincy Seigel, Spencer Lee, Emily Green, Sara Chitlik, Veronika Lobova, Paul Eastvold, Chris Gresens, Erin A Kaya  \nSpecialty type: Oncology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B  \nNovelty: Grade A  \nCreativity or Innovation: Grade A  \nScientific Significance: Grade A  \nP-Reviewer: Lin JY, MD, PhD, United States  \nReceived: November 28, 2024  \nRevised: March 9, 2025  \nAccepted: November 14, 2025  \nPublished online: December 24, 2025  \nProcessing time: 391 Days and 2.2 Hours  \nJonah Lee, Spencer Lee, Department of Radiation Oncology, Cancer Care Northwest, Spokane, WA 99204, United States  \nQuincy Seigel, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, TX 77555, United States  \nEmily Green, College of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States  \nSara Chitlik, College of Medicine, Rush Medical College, Chicago, IL 60612, United States Veronika Lobova, General Surgery, UCSF Fresno Surgery, Fresno, CA 93701, United States Paul Eastvold, Chris Gresens, Blood Center, Vitalant Blood Centers, Spokane, WA 99201, United States  \nErin A Kaya, Department of Radiation Oncology, Oregon Health Sciences University, Portland, OR 97239, United States  \nCorresponding author: Erin A Kaya, MD, Department of Radiation Oncology, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239, United States.  \n[erinkaya@berkeley.edu](erinkaya@berkeley.edu)  \nAbstract  \nBACKGROUND  \nThe purpose of this paper is to demonstrate a practical stem cell collection method that provides sufficient stem cells for autologous stem cell transplantation (ASCT) in multiple myeloma (MM) patients despite low peripheral CD34 (pCD34) countsand to describe the benefits of this method for MM patients with limited resources.  \nAIM  \nTo demonstrate a practical method for stem cell collection.  \nMETHODS  \nStem cell collection data on the last 300 patients at a community cancer center in Washington were reviewed. We report on the methods of collection, including medi-cations used and timing, used by the blood blank as well as their outcomes.  \n WJCO  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 24, 2025  Volume 16  Issue 12   \nLee J et al. Successful stem cell collection low CD34  \nThe three MM patients with initially very low pCD34 counts all successfully underwent stem cell collection in a single trip to the transplant center for their ASCT.  \nRESULTS  \nThree patients whose pre-collection pCD34 counts were the lowest and less than 2.5 cells/μL were identified. These patients had the commonality of having multiple barriers to transportation and likely would have been able to make only one trip for the stem cell collections.  \nCONCLUSION  \nDespite particularly low pre-collection peripheral blood CD34 counts, successful autologous stem cell collection in MM patients is feasible by routinely adding plerixafor to granulocyte-colony stimulating factor on day 4 of mobilization. There is limited analysis demonstrating that sufficient stem cells for one or more transplants can be collected using this method. This practical and novel approach may benefit the high number of MM patients who face limited resources, finances, long travel times, and social support. These results are highly relevant to physicians treating similar patients.  \nKey Words: Multiple myeloma; Stem cell collection; Plerixafor; Peripheral CD43","cbCaiu921OvUcPCb","https://ap.wps.com/l/cbCaiu921OvUcPCb","pdf",408864,"English","# Abstract\n## Background\n## Aim\n## Methods\n## Results\n## Conclusion\n# Core Tip","[{\"question\":\"What is the main purpose of the study?\",\"answer\":\"To demonstrate a practical stem cell collection method that provides enough stem cells for autologous stem cell transplantation in multiple myeloma patients despite low peripheral CD34 counts, and to describe its benefits for patients with limited resources.\"},{\"question\":\"How were the study data collected and analyzed?\",\"answer\":\"Stem cell collection data from the last 300 patients at a community cancer center in Washington were reviewed, including collection methods, medications used, timing, and outcomes.\"},{\"question\":\"What intervention is recommended for low peripheral CD34 counts?\",\"answer\":\"Routinely adding plerixafor to granulocyte-colony stimulating factor on day 4 of mobilization to enable successful autologous stem cell collection even with very low peripheral CD34.\"}]","World Journal of Clinical Oncology - Original Article - Retrospective Study - Stem cell collection from peripheral blood of multiple myeloma patients | PDF",1790564257,23]