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It highlights studies including mechanisms and potential therapies for bronchopulmonary dysplasia (BPD) in newborns, emphasizing how oxygen-related hyperoxia can drive lung injury through inflammatory signaling and immune cell dysfunction. The piece also summarizes findings on TRIM72 overexpression under hyperoxic conditions and discusses how this may contribute to epithelial damage, extracellular matrix remodeling, and BPD development, while noting apparent inconsistencies with prior protective roles.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/winners-of-the-2021-honor-awards-for-excellence-at-the-annual-meeting-of-the-chinese-medical-association-taipei-part-ii/436449/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/winners-of-the-2021-honor-awards-for-excellence-at-the-annual-meeting-of-the-chinese-medical-association-taipei-part-ii/436449.png","ImageObject",300,407,{"name":92,"@type":93},"Jacob","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-01","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does Part II of the editorial focus on?","Question",{"text":112,"@type":113},"Part II introduces four additional excellent researchers honored at the 2021 CMA-Taipei annual meeting, along with the relevance of their academic work to future patient care.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why is bronchopulmonary dysplasia (BPD) discussed in relation to oxygen?",{"text":117,"@type":113},"The editorial explains that premature newborns often require oxygen supplementation due to respiratory dysfunction, but excessive oxygen can cause hyperoxia, leading to lung injury and contributing to BPD development.",{"name":119,"@type":110,"acceptedAnswer":120},"What role does TRIM72 play according to the highlighted study?",{"text":121,"@type":113},"The study summarized in the editorial reports that hyperoxia causes TRIM72 overexpression, which is linked to alveolar epithelial cell death and extracellular matrix remodeling, suggesting TRIM72 upregulation may contribute to hyperoxia-induced lung injury and BPD.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436449,1790813609,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":39},962084931830,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","J Chin MedAssoc  \nEditorial  \nWinners of the 2021 honor awards for excellence at the annual meeting of the Chinese Medical Association-Taipei: Part II  \nPeng-Hui Wanga,b,c,d,* , Teh-Ia Huoe,f  \naDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; bInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; cFemale Cancer Foundation, Taipei, Taiwan, ROC; dDepartment of Medical Research, China Medical University Hospital, Taichung, Taiwan, ROC; eDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, ROC; fInstitute of Pharmacology, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC  \nIn Part I,1 we congratulated five outstanding researchers winning the 2021 Outstanding Research Paper Awards who were selected from all research articles published in 2021 issues of the Journal of the Chinese Medical Association (JCMA) which got a new achievement of 2021 impact factor (IF) as 3.396 atthe Annual Meeting of the Chinese Medical Association-Taipei ( CMA-Taipei) on July 16, 2022, Taipei, Taiwan.1,2 The current editorial is a “Part II,” which introduces another four excellent researchers with their academic professions to explore a brandnew vision for future patient’s care.3–6 By the way, the top-cited article is simultaneously announced here.7  \nDr. Huang and colleagues tried their best to explore the possible underlying pathophysiology about bronchopulmonary dysplasia (BPD) in newborns, and their findings made them win one of the CMA-Taipei Outstanding Research Work Awards.3 BPD, the main cause of infant’s death and if survived, a severe long-term complication, secondary to respiratory distress syndrome and acute lung injury-related respiratory failure, which may deteriorate the overall quality of life of newborns and their subsequent life (asthma, repeated respiratory infection, low exercise capacity and early-onset emphysema, and subsequent development of pulmonary-cardiovascular dysfunction), is frequently occurred in premature deliveries (\u003C37 weeks of gestational age) .8–10 Oxygen (O2 ) supplement is always needed for these premature newborns due to their dysfunction of the respiratory system, which cannot maintain adequate oxygen to supply to the body, resulting in an uncompensated hypoxia. However, an overdose of O2 supply may result in hyperoxia of lung, causing lung injury and subsequently implicated in the pathogenesis of BPD. Many altered depositions of various  \n*Address correspondence. Dr. Peng-Hui Wang, Department of Obstetricsand Gynecology, Taipei Veterans General Hospital, 201, Section 2, Shi-Pai Road, Taipei 112, Taiwan, [ROC. E-mail addresses: phwang@vghtpe.gov.tw](ROC. E-mail addresses: phwang@vghtpe.gov.tw); [pongpongwang@gmail.com](pongpongwang@gmail.com) (P.-H. Wang).  \nConflicts of interest: Drs. Peng-Hui Wang and Teh-Ia Huo, editorial board members at Journal of the Chinese Medical Association, have no roles in the peer review process of or decision to publish this article. Both doctors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2022) 85: 1035-1037. Received July 20, 2022; accepted. July 21, 2022  \ndoi: 10. 1097/JCMA.0000000000000790.  \nCopyright © 2022, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)[ ](http://creativecommons.org/licenses/)[by-nc-nd/4.0/](by-nc-nd/4.0/))  \ncytokines, proinflammatory factors, and inflammatory factors are detected during the lung injury, which include upregulation of chemokine-mediated signaling and immune cell chemotaxis, and defective development of T lymphocytes.10 All are reported to be associated with the development of BPD.10 As mentioned by Dr. Huang, the role of tripartite motif protein 72 (TRIM72) in the pathogenesis of hyperox","cbCaiuk2onNw98Ud","https://ap.wps.com/l/cbCaiuk2onNw98Ud","pdf",315116,"English","# Editorial\n## Part II overview\n## Highlighted research: BPD mechanisms and oxygen toxicity\n## TRIM72 in hyperoxia-induced lung injury\n## Implications for future longitudinal studies","[{\"question\":\"What does Part II of the editorial focus on?\",\"answer\":\"Part II introduces four additional excellent researchers honored at the 2021 CMA-Taipei annual meeting, along with the relevance of their academic work to future patient care.\"},{\"question\":\"Why is bronchopulmonary dysplasia (BPD) discussed in relation to oxygen?\",\"answer\":\"The editorial explains that premature newborns often require oxygen supplementation due to respiratory dysfunction, but excessive oxygen can cause hyperoxia, leading to lung injury and contributing to BPD development.\"},{\"question\":\"What role does TRIM72 play according to the highlighted study?\",\"answer\":\"The study summarized in the editorial reports that hyperoxia causes TRIM72 overexpression, which is linked to alveolar epithelial cell death and extracellular matrix remodeling, suggesting TRIM72 upregulation may contribute to hyperoxia-induced lung injury and BPD.\"}]","Winners of the 2021 honor awards for excellence at the annual meeting of the Chinese Medical Association-Taipei - Part II | PDF",1790677981]